Cited 395 times in
Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage
DC Field | Value | Language |
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dc.contributor.author | 이서구 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 배수한 | - |
dc.contributor.author | 성수행 | - |
dc.date.accessioned | 2014-12-18T09:58:00Z | - |
dc.date.available | 2014-12-18T09:58:00Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1550-4131 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89166 | - |
dc.description.abstract | Sestrins (Sesns) protect cells from oxidative stress. The mechanism underlying the antioxidant effect of Sesns has remained unknown, however. The Nrf2-Keap1 pathway provides cellular defense against oxidative stress by controlling the expression of antioxidant enzymes. We now show that Sesn1 and Sesn2 interact with the Nrf2 suppressor Keap1, the autophagy substrate p62, and the ubiquitin ligase Rbx1 and that the antioxidant function of Sesns is mediated through activation of Nrf2 in a manner reliant on p62-dependent autophagic degradation of Keap1. Sesn2 was upregulated in the liver of mice subjected to fasting or subsequent refeeding with a high-carbohydrate, fat-free diet, whereas only refeeding promoted Keap1 degradation and Nrf2 activation, because only refeeding induced p62 expression. Ablation of Sesn2 blocked Keap1 degradation and Nrf2 activation induced by refeeding and thereby increased the susceptibility of the liver to oxidative damage resulting from the acute stimulation of lipogenesis associated with refeeding. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CELL METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adaptor Proteins, Signal Transducing/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Autophagy | - |
dc.subject.MESH | Carrier Proteins/metabolism | - |
dc.subject.MESH | Cell Cycle Proteins/metabolism | - |
dc.subject.MESH | Cytoskeletal Proteins/metabolism* | - |
dc.subject.MESH | HCT116 Cells | - |
dc.subject.MESH | HEK293 Cells | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kelch-Like ECH-Associated Protein 1 | - |
dc.subject.MESH | Liver/metabolism* | - |
dc.subject.MESH | Liver/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | NF-E2-Related Factor 2/metabolism* | - |
dc.subject.MESH | Nuclear Proteins | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Proteins/metabolism* | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | Up-Regulation | - |
dc.title | Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Soo Han Bae | - |
dc.contributor.googleauthor | Su Haeng Sung | - |
dc.contributor.googleauthor | Sue Young Oh | - |
dc.contributor.googleauthor | Jung Mi Lim | - |
dc.contributor.googleauthor | Se Kyoung Lee | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Hye Eun Lee | - |
dc.contributor.googleauthor | Dongmin Kang | - |
dc.contributor.googleauthor | Sue Goo Rhee | - |
dc.identifier.doi | 10.1016/j.cmet.2012.12.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02847 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01798 | - |
dc.contributor.localId | A01948 | - |
dc.relation.journalcode | J00486 | - |
dc.identifier.eissn | 1932-7420 | - |
dc.identifier.pmid | 23274085 | - |
dc.subject.keyword | Adaptor Proteins, Signal Transducing/metabolism* | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Autophagy | - |
dc.subject.keyword | Carrier Proteins/metabolism | - |
dc.subject.keyword | Cell Cycle Proteins/metabolism | - |
dc.subject.keyword | Cytoskeletal Proteins/metabolism* | - |
dc.subject.keyword | HCT116 Cells | - |
dc.subject.keyword | HEK293 Cells | - |
dc.subject.keyword | HeLa Cells | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Kelch-Like ECH-Associated Protein 1 | - |
dc.subject.keyword | Liver/metabolism* | - |
dc.subject.keyword | Liver/physiopathology | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred C57BL | - |
dc.subject.keyword | NF-E2-Related Factor 2/metabolism* | - |
dc.subject.keyword | Nuclear Proteins | - |
dc.subject.keyword | Oxidative Stress | - |
dc.subject.keyword | Protein Binding | - |
dc.subject.keyword | Proteins/metabolism* | - |
dc.subject.keyword | Transcription Factors/metabolism* | - |
dc.subject.keyword | Transfection | - |
dc.subject.keyword | Up-Regulation | - |
dc.contributor.alternativeName | Rhee, Sue Goo | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Bae, Soo Han | - |
dc.contributor.alternativeName | Sung, Su Haeng | - |
dc.contributor.affiliatedAuthor | Rhee, Sue Goo | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Bae, Soo Han | - |
dc.contributor.affiliatedAuthor | Sung, Su Haeng | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 84 | - |
dc.identifier.bibliographicCitation | CELL METABOLISM, Vol.17(1) : 73-84, 2013 | - |
dc.identifier.rimsid | 34416 | - |
dc.type.rims | ART | - |
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