Cited 0 times in
Immunuglobulin A 신질환과 Henoch-Schnlein purpura 신질환을 가진 소아에서의 cyclosporine A와angiotensin-converting enzyme inhibitor 치료의 임상적, 병리학적 변화
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2014-12-18T09:57:17Z | - |
dc.date.available | 2014-12-18T09:57:17Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1226-5292 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89143 | - |
dc.description.abstract | Purpose: To investigate the clinicopathologic effects of cyclosporine A (CsA) in children with diseases characterized by mesangial immunoglobulin A deposits such as immunoglobulin A nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN). Methods: We retrospectively reviewed the clinicopathologic outcomes of 54 children (IgAN, 36; HSPN, 18) treated with CsA. The starting dose of CsA was 5 mg/kg per day, and it was administered in 2 divided doses. The degree of proteinuria and pathologic changes in renal biopsies were evaluated before and after CsA treatment. Results: The mean protein to creatinine ratio decreased from 3.7±1.5 to 0.6±0.4 (P<0.001), and 32 (59.2%) children achieved complete remission of proteinuria after 1-year CsA treatment. Among the 54 children, 24 maintained normal renal function and 25 exhibited microscopic hematuria or proteinuria at the end of CsA treatment. In the HSPN group, 3 children whose initial biopsies indicated class IIIb disease showed class II disease on follow-up, and the follow-up biopsies of 2 children who had class II disease indicated the same class II disease. In the IgAN group, cortical tubular atrophy occurred in 1 child, and no child with IgAN had cortical interstitial fibrosis or tubular atrophy after 1-year CsA treatment. No significant complications were found in the children treated with CsA. Conclusion: Our findings indicate that CsA treatment is effective and beneficial in reducing massive proteinuria and preventing progression to end-stage renal failure in children with glomerular diseases characterized by IgA deposits, such as IgAN and HSPN, within 1 year of treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Immunuglobulin A 신질환과 Henoch-Schnlein purpura 신질환을 가진 소아에서의 cyclosporine A와angiotensin-converting enzyme inhibitor 치료의 임상적, 병리학적 변화 | - |
dc.title.alternative | Clinicopathologic Changes in Children with Immunoglobulin A Nephritis and Henoch-Schönlein Purpura Nephritis after Cyclosporine A and Angiotensin-converting Enzyme Inhibitor Treatment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Jeong Ju Lee | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Hyunee Yim | - |
dc.contributor.googleauthor | Se Jin Park | - |
dc.identifier.doi | 10.3339/jkspn.2013.17.2.92 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J01885 | - |
dc.identifier.pmid | IgA deposit ; IgA nephropathy ; Henoch-Schönlein purpura nephritis ; cyclosporine A | - |
dc.subject.keyword | IgA deposit | - |
dc.subject.keyword | IgA nephropathy | - |
dc.subject.keyword | Henoch-Schönlein purpura nephritis | - |
dc.subject.keyword | cyclosporine A | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | Shin, Jae Il | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 92 | - |
dc.citation.endPage | 100 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지), Vol.17(2) : 92-100, 2013 | - |
dc.identifier.rimsid | 33830 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.