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Long-Term Outcomes of Total Thyroidectomy Versus Thyroid Lobectomy for Papillary Thyroid Microcarcinoma: Comparative Analysis After Propensity Score Matching

DC FieldValueLanguage
dc.contributor.author박정수-
dc.contributor.author이잔디-
dc.contributor.author이초록-
dc.contributor.author정웅윤-
dc.date.accessioned2014-12-18T09:55:45Z-
dc.date.available2014-12-18T09:55:45Z-
dc.date.issued2013-
dc.identifier.issn1050-7256-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89094-
dc.description.abstractAIMS: The objectives of this study were to compare long-term outcomes after total thyroidectomy (TT) or thyroid lobectomy (LT) in a large cohort of patients with papillary thyroid microcarcinoma (PTMC), and to determine whether tumor size (≤0.5 cm vs. >0.5 cm) has a significant impact on the extent of surgery. METHODS: We evaluated 2014 patients with PTMC who underwent TT with central compartment node dissection (CCND; n = 1015) or LT with CCND (n = 999) between March 1986 and December 2006 and for whom complete follow-up data were available for at least 5 years (median 11.8 years, range 5-26 years). Using propensity score matching to reduce the impact of treatment selection bias and potential confounding in an observational study, we compared overall survival and disease-free survival in the overall cohort and in patients with tumors ≤0.5 cm and >0.5 cm in size. RESULTS: After adjustment for differences in baseline clinicopathologic risk factors, we observed no significant differences between the LT and the TT groups in the risk of death (hazard ratio for the LT group 1.05, 95% confidence interval [CI] 0.71-1.47, p = 0.890) and locoregional recurrence (hazard ratio for the LT group 3.08 [CI 1.99-8.05], p = 0.194) in the overall matched cohort. Similar results were observed when we compared LT and TT in patients with tumors ≤0.5 cm and >0.5 cm. CONCLUSIONS: The long-term rates of death and locoregional recurrence were similar in patients with PTMC who underwent LT with CCND and those who underwent TT with CCND. Therefore, completion thyroidectomy may not be recommended unless recurrence after LT is definitely detected in low-risk PTMC patients, and close follow-up is adequate in these patients. Moreover, tumor size greater than or less than 0.5 cm was not a significant determinant of the extent of surgery in patients with PTMC.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTHYROID-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCarcinoma, Papillary/mortality-
dc.subject.MESHCarcinoma, Papillary/surgery*-
dc.subject.MESHCohort Studies-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHPropensity Score-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRisk Factors-
dc.subject.MESHThyroid Gland/surgery*-
dc.subject.MESHThyroid Neoplasms/mortality-
dc.subject.MESHThyroid Neoplasms/surgery*-
dc.subject.MESHThyroidectomy/methods*-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleLong-Term Outcomes of Total Thyroidectomy Versus Thyroid Lobectomy for Papillary Thyroid Microcarcinoma: Comparative Analysis After Propensity Score Matching-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJandee Lee-
dc.contributor.googleauthorJae Hyun Park-
dc.contributor.googleauthorCho-Rok Lee-
dc.contributor.googleauthorWoong Youn Chung-
dc.contributor.googleauthorCheong Soo Park-
dc.identifier.doi10.1089/thy.2012.0463-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01646-
dc.contributor.localIdA03066-
dc.contributor.localIdA03256-
dc.contributor.localIdA03674-
dc.relation.journalcodeJ02729-
dc.identifier.eissn1557-9077-
dc.identifier.pmid23509895-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/thy.2012.0463-
dc.subject.keywordAdult-
dc.subject.keywordCarcinoma, Papillary/mortality-
dc.subject.keywordCarcinoma, Papillary/surgery*-
dc.subject.keywordCohort Studies-
dc.subject.keywordDatabases, Factual-
dc.subject.keywordDisease-Free Survival-
dc.subject.keywordFemale-
dc.subject.keywordFollow-Up Studies-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordNeoplasm Recurrence, Local-
dc.subject.keywordPropensity Score-
dc.subject.keywordProportional Hazards Models-
dc.subject.keywordRisk Factors-
dc.subject.keywordThyroid Gland/surgery*-
dc.subject.keywordThyroid Neoplasms/mortality-
dc.subject.keywordThyroid Neoplasms/surgery*-
dc.subject.keywordThyroidectomy/methods*-
dc.subject.keywordTime Factors-
dc.subject.keywordTreatment Outcome-
dc.contributor.alternativeNamePark, Cheong Soo-
dc.contributor.alternativeNameLee, Jan Dee-
dc.contributor.alternativeNameLee, Cho Rok-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.affiliatedAuthorPark, Cheong Soo-
dc.contributor.affiliatedAuthorLee, Jan Dee-
dc.contributor.affiliatedAuthorLee, Cho Rok-
dc.contributor.affiliatedAuthorChung, Woung Youn-
dc.rights.accessRightsnot free-
dc.citation.volume23-
dc.citation.number11-
dc.citation.startPage1408-
dc.citation.endPage1415-
dc.identifier.bibliographicCitationTHYROID, Vol.23(11) : 1408-1415, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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