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Oral Tranexamic Acid Enhances the Efficacy of Low-Fluence 1064-Nm Quality-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for Melasma in Koreans: A Randomized, Prospective Trial

DC Field Value Language
dc.contributor.author신정우-
dc.contributor.author오상호-
dc.contributor.author이주희-
dc.date.accessioned2014-12-18T09:54:32Z-
dc.date.available2014-12-18T09:54:32Z-
dc.date.issued2013-
dc.identifier.issn1076-0512-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89055-
dc.description.abstractBACKGROUND: Tranexamic acid (TA) has recently gained in popularity in the treatment of pigmentary disorders. OBJECTIVE: To evaluate the clinical efficacy and safety of oral TA combined with low-fluence 1064-nm quality-switched neodymium-doped yttrium aluminum garnet (QSNY) laser for the treatment of melasma. MATERIALS AND METHODS: Forty-eight patients with melasma were enrolled in the study and subsequently divided into two groups: a combination group and a laser treatment group. All patients were treated with two sessions of low-fluence QSNY laser, and patients in the combination group took 8 weeks of oral TA. Two blinded dermatologists evaluated patients using the Modified Melasma Area and Severity Index (mMASI) and a clinical improvement scale. RESULTS: Mean mMASI score 4 weeks after the second treatment decreased significantly in both groups from base line. Based on overall clinical improvement, a greater number of patients scored as grade 3 and more in the combination group; no patients were scored as grade 4 in the laser-alone group. CONCLUSIONS: Oral TA may prove a safe and efficient treatment option for melasma in combination with low-fluence QSNY laser therapy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfDERMATOLOGIC SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleOral Tranexamic Acid Enhances the Efficacy of Low-Fluence 1064-Nm Quality-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for Melasma in Koreans: A Randomized, Prospective Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorJung U Shin-
dc.contributor.googleauthorJihun Park-
dc.contributor.googleauthorSang Ho Oh-
dc.contributor.googleauthorJu Hee Lee-
dc.identifier.doi10.1111/dsu.12060-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02149-
dc.contributor.localIdA02370-
dc.contributor.localIdA03171-
dc.relation.journalcodeJ00707-
dc.identifier.eissn1524-4725-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/dsu.12060/abstract-
dc.contributor.alternativeNameShin, Jung U-
dc.contributor.alternativeNameOh, Sang Ho-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.affiliatedAuthorShin, Jung U-
dc.contributor.affiliatedAuthorOh, Sang Ho-
dc.contributor.affiliatedAuthorLee, Ju Hee-
dc.rights.accessRightsnot free-
dc.citation.volume39-
dc.citation.number3 Pt 1-
dc.citation.startPage435-
dc.citation.endPage442-
dc.identifier.bibliographicCitationDERMATOLOGIC SURGERY, Vol.39(3 Pt 1) : 435-442, 2013-
dc.identifier.rimsid33770-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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