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Oral Tranexamic Acid Enhances the Efficacy of Low-Fluence 1064-Nm Quality-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for Melasma in Koreans: A Randomized, Prospective Trial
DC Field | Value | Language |
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dc.contributor.author | 신정우 | - |
dc.contributor.author | 오상호 | - |
dc.contributor.author | 이주희 | - |
dc.date.accessioned | 2014-12-18T09:54:32Z | - |
dc.date.available | 2014-12-18T09:54:32Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1076-0512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89055 | - |
dc.description.abstract | BACKGROUND: Tranexamic acid (TA) has recently gained in popularity in the treatment of pigmentary disorders. OBJECTIVE: To evaluate the clinical efficacy and safety of oral TA combined with low-fluence 1064-nm quality-switched neodymium-doped yttrium aluminum garnet (QSNY) laser for the treatment of melasma. MATERIALS AND METHODS: Forty-eight patients with melasma were enrolled in the study and subsequently divided into two groups: a combination group and a laser treatment group. All patients were treated with two sessions of low-fluence QSNY laser, and patients in the combination group took 8 weeks of oral TA. Two blinded dermatologists evaluated patients using the Modified Melasma Area and Severity Index (mMASI) and a clinical improvement scale. RESULTS: Mean mMASI score 4 weeks after the second treatment decreased significantly in both groups from base line. Based on overall clinical improvement, a greater number of patients scored as grade 3 and more in the combination group; no patients were scored as grade 4 in the laser-alone group. CONCLUSIONS: Oral TA may prove a safe and efficient treatment option for melasma in combination with low-fluence QSNY laser therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | DERMATOLOGIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Oral Tranexamic Acid Enhances the Efficacy of Low-Fluence 1064-Nm Quality-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for Melasma in Koreans: A Randomized, Prospective Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Jung U Shin | - |
dc.contributor.googleauthor | Jihun Park | - |
dc.contributor.googleauthor | Sang Ho Oh | - |
dc.contributor.googleauthor | Ju Hee Lee | - |
dc.identifier.doi | 10.1111/dsu.12060 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02149 | - |
dc.contributor.localId | A02370 | - |
dc.contributor.localId | A03171 | - |
dc.relation.journalcode | J00707 | - |
dc.identifier.eissn | 1524-4725 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/dsu.12060/abstract | - |
dc.contributor.alternativeName | Shin, Jung U | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.alternativeName | Lee, Ju Hee | - |
dc.contributor.affiliatedAuthor | Shin, Jung U | - |
dc.contributor.affiliatedAuthor | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | Lee, Ju Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 Pt 1 | - |
dc.citation.startPage | 435 | - |
dc.citation.endPage | 442 | - |
dc.identifier.bibliographicCitation | DERMATOLOGIC SURGERY, Vol.39(3 Pt 1) : 435-442, 2013 | - |
dc.identifier.rimsid | 33770 | - |
dc.type.rims | ART | - |
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