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MicroRNAs as novel regulators of stem cell fate

Authors
 Eunhyun Choi  ;  Eunmi Choi  ;  Ki-Chul Hwang 
Citation
 World Journal of Stem Cells, Vol.5(4) : 172-187, 2013 
Journal Title
 World Journal of Stem Cells 
ISSN
 1948-0210 
Issue Date
2013
Abstract
Mounting evidence in stem cell biology has shown that microRNAs (miRNAs) play a crucial role in cell fate specification, including stem cell self-renewal, lineage-specific differentiation, and somatic cell reprogramming. These functions are tightly regulated by specific gene expression patterns that involve miRNAs and transcription factors. To maintain stem cell pluripotency, specific miRNAs suppress transcription factors that promote differentiation, whereas to initiate differentiation, lineage-specific miRNAs are upregulated via the inhibition of transcription factors that promote self-renewal. Small molecules can be used in a similar manner as natural miRNAs, and a number of natural and synthetic small molecules have been isolated and developed to regulate stem cell fate. Using miRNAs as novel regulators of stem cell fate will provide insight into stem cell biology and aid in understanding the molecular mechanisms and crosstalk between miRNAs and stem cells. Ultimately, advances in the regulation of stem cell fate will contribute to the development of effective medical therapies for tissue repair and regeneration. This review summarizes the current insights into stem cell fate determination by miRNAs with a focus on stem cell self-renewal, differentiation, and reprogramming. Small molecules that control stem cell fate are also highlighted.
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DOI
10.4252/wjsc.v5.i4.172
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
Yonsei Authors
최은미(Choi, Eun Mi)
최은현(Choi, Eun Hyun)
황기철(Hwang, Ki Chul)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88943
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