Cited 5 times in
Clinical features and survival outcomes of patients with diffuse large B-cell lymphoma: analysis of web-based data from the Korean Lymphoma Working Party Registry
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.contributor.author | 민유홍 | - |
dc.date.accessioned | 2014-12-18T09:50:35Z | - |
dc.date.available | 2014-12-18T09:50:35Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2287-979X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88933 | - |
dc.description.abstract | BACKGROUND: This study aimed to survey the clinical spectrum of diffuse large B-cell lymphoma (DLBCL) in terms of epidemiology, pathologic subtypes, stage, and prognostic index as well as treatment outcomes. METHODS: In 2007-2008, 13 university hospitals evenly distributed in the Korean peninsula contributed to the online registry of DLBCL at www.lymphoma.or.kr and filed a total of 1,665 cases of DLBCL recorded since 1990. RESULTS: Our analysis showed a higher prevalence of DLBCL in male than in female individuals (M:F=958:707), and extranodal disease was more common than primary nodular disease (53% vs. 47%). Among the 1,544 patients who had been treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) or rituximab-CHOP (R-CHOP) therapy with or without radiation, 993 (63.9%) were alive, with 80% free of disease, 417 were dead (26.8%), with 13% free of disease, and 144 (9.3%) were lost to follow-up, with 23% free of disease. Age below 60 years, stage at diagnosis, international prognostic index (IPI) score regardless of age, and addition of rituximab to CHOP therapy in low- and low-intermediate-risk groups according to IPI scores significantly increased survival duration. CONCLUSION: The epidemiology, clinical spectrum, and biological behavior of DLBCL in Korea are similar to those observed in Western countries, and the advent of rituximab improved survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BLOOD RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical features and survival outcomes of patients with diffuse large B-cell lymphoma: analysis of web-based data from the Korean Lymphoma Working Party Registry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyeon Gyu Yi | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Cheolwon Suh | - |
dc.contributor.googleauthor | Won Seog Kim | - |
dc.contributor.googleauthor | Jae-Yong Kwak | - |
dc.contributor.googleauthor | Jong-Seok Lee | - |
dc.contributor.googleauthor | Yang Soo Kim | - |
dc.contributor.googleauthor | Young Don Joo | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | Hong Ghi Lee | - |
dc.contributor.googleauthor | Sung-Soo Yoon | - |
dc.contributor.googleauthor | Jong-Ho Won | - |
dc.contributor.googleauthor | Seonyang Park | - |
dc.contributor.googleauthor | Hugh Chul Kim | - |
dc.contributor.googleauthor | Chul Soo Kim | - |
dc.identifier.doi | 10.5045/br.2013.48.2.115 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A01407 | - |
dc.relation.journalcode | J00346 | - |
dc.identifier.eissn | 2288-0011 | - |
dc.identifier.pmid | 23826580 | - |
dc.subject.keyword | CHOP regimen | - |
dc.subject.keyword | Diffuse large B-cell lymphoma | - |
dc.subject.keyword | Epidemiology | - |
dc.subject.keyword | Rituximab | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 48 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 115 | - |
dc.citation.endPage | 120 | - |
dc.identifier.bibliographicCitation | BLOOD RESEARCH, Vol.48(2) : 115-120, 2013 | - |
dc.identifier.rimsid | 33684 | - |
dc.type.rims | ART | - |
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