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Predictive value of the smell identification test for nigrostriatal dopaminergic depletion in Korean tremor patients

DC FieldValueLanguage
dc.contributor.author홍진용-
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이지은-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.date.accessioned2014-12-18T09:50:08Z-
dc.date.available2014-12-18T09:50:08Z-
dc.date.issued2013-
dc.identifier.issn1353-8020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88920-
dc.description.abstractBACKGROUND: The predictive value of Cross-Cultural Smell Identification Test for nigrostriatal dopaminergic depletion in Korean tremor patients has yet to be assessed. METHODS: Three hundred nineteen drug-naive patients who visited our clinic for the diagnosis of their tremor, and took both Cross-Cultural Smell Identification Test and dopamine transporter PET were included in the data analysis. Visual grading of each PET image was performed by two independent neurologists. RESULTS: Smell test scores were significantly correlated to the striatal dopaminergic activity (Kendall's τb = -0.291, p < 0.001). However, smell test score alone appeared to have relatively weak power for predicting dopaminergic depletion (area under the curve = 0.693). Multivariate logistic regression model with inclusion of the patient's age and symptom duration as independent variables enhanced predictive power for dopaminergic depletion (area under the curve = 0.812). CONCLUSIONS: These results demonstrated that Cross-Cultural Smell Identification Test measurements alone may be insufficient to predict striatal dopaminergic depletion in Korean tremor patients.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPARKINSONISM & RELATED DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCorpus Striatum/diagnostic imaging-
dc.subject.MESHCorpus Striatum/metabolism*-
dc.subject.MESHCross-Cultural Comparison*-
dc.subject.MESHDopamine/metabolism*-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPositron-Emission Tomography/methods-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRepublic of Korea/ethnology-
dc.subject.MESHSingle-Blind Method-
dc.subject.MESHSmell/physiology*-
dc.subject.MESHSubstantia Nigra/diagnostic imaging-
dc.subject.MESHSubstantia Nigra/metabolism*-
dc.subject.MESHTremor/diagnosis*-
dc.subject.MESHTremor/ethnology*-
dc.titlePredictive value of the smell identification test for nigrostriatal dopaminergic depletion in Korean tremor patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorJi E. Lee-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.identifier.doi10.1016/j.parkreldis.2013.07.008-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04442-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA03210-
dc.relation.journalcodeJ02468-
dc.identifier.eissn1873-5126-
dc.identifier.pmid23920135-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1353802013002629-
dc.subject.keywordCross-Cultural Smell Identification Test-
dc.subject.keywordDopamine transporter-
dc.subject.keywordFP-CIT-
dc.subject.keywordHyposmia-
dc.subject.keywordParkinson's disease-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Ji Eun-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorLee, Ji Eun-
dc.rights.accessRightsnot free-
dc.citation.volume19-
dc.citation.number11-
dc.citation.startPage1018-
dc.citation.endPage1021-
dc.identifier.bibliographicCitationPARKINSONISM & RELATED DISORDERS, Vol.19(11) : 1018-1021, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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