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Predictive value of the smell identification test for nigrostriatal dopaminergic depletion in Korean tremor patients

 Jin Yong Hong  ;  Seok Jong Chung  ;  Ji E. Lee  ;  Mun Kyung Sunwoo  ;  Phil Hyu Lee  ;  Young H. Sohn 
 Parkinsonism & Related Disorders, Vol.19(11) : 1018-1021, 2013 
Journal Title
 Parkinsonism & Related Disorders 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism* ; Cross-Cultural Comparison* ; Dopamine/metabolism* ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Female ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography/methods ; Predictive Value of Tests ; Republic of Korea/ethnology ; Single-Blind Method ; Smell/physiology* ; Substantia Nigra/diagnostic imaging ; Substantia Nigra/metabolism* ; Tremor/diagnosis* ; Tremor/ethnology*
Cross-Cultural Smell Identification Test ; Dopamine transporter ; FP-CIT ; Hyposmia ; Parkinson's disease
BACKGROUND: The predictive value of Cross-Cultural Smell Identification Test for nigrostriatal dopaminergic depletion in Korean tremor patients has yet to be assessed. METHODS: Three hundred nineteen drug-naive patients who visited our clinic for the diagnosis of their tremor, and took both Cross-Cultural Smell Identification Test and dopamine transporter PET were included in the data analysis. Visual grading of each PET image was performed by two independent neurologists. RESULTS: Smell test scores were significantly correlated to the striatal dopaminergic activity (Kendall's τb = -0.291, p < 0.001). However, smell test score alone appeared to have relatively weak power for predicting dopaminergic depletion (area under the curve = 0.693). Multivariate logistic regression model with inclusion of the patient's age and symptom duration as independent variables enhanced predictive power for dopaminergic depletion (area under the curve = 0.812). CONCLUSIONS: These results demonstrated that Cross-Cultural Smell Identification Test measurements alone may be insufficient to predict striatal dopaminergic depletion in Korean tremor patients.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sunwoo, Mun Kyung(선우문경)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
Hong, Jin Yong(홍진용)
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