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Predictive value of the smell identification test for nigrostriatal dopaminergic depletion in Korean tremor patients

Authors
 Jin Yong Hong  ;  Seok Jong Chung  ;  Ji E. Lee  ;  Mun Kyung Sunwoo  ;  Phil Hyu Lee  ;  Young H. Sohn 
Citation
 Parkinsonism & Related Disorders, Vol.19(11) : 1018-1021, 2013 
Journal Title
 Parkinsonism & Related Disorders 
ISSN
 1353-8020 
Issue Date
2013
Abstract
BACKGROUND: The predictive value of Cross-Cultural Smell Identification Test for nigrostriatal dopaminergic depletion in Korean tremor patients has yet to be assessed. METHODS: Three hundred nineteen drug-naive patients who visited our clinic for the diagnosis of their tremor, and took both Cross-Cultural Smell Identification Test and dopamine transporter PET were included in the data analysis. Visual grading of each PET image was performed by two independent neurologists. RESULTS: Smell test scores were significantly correlated to the striatal dopaminergic activity (Kendall's τb = -0.291, p < 0.001). However, smell test score alone appeared to have relatively weak power for predicting dopaminergic depletion (area under the curve = 0.693). Multivariate logistic regression model with inclusion of the patient's age and symptom duration as independent variables enhanced predictive power for dopaminergic depletion (area under the curve = 0.812). CONCLUSIONS: These results demonstrated that Cross-Cultural Smell Identification Test measurements alone may be insufficient to predict striatal dopaminergic depletion in Korean tremor patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S1353802013002629
DOI
10.1016/j.parkreldis.2013.07.008
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
선우문경(Sunwoo, Mun Kyung)
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
이지은(Lee, Ji Eun)
이필휴(Lee, Phil Hyu)
정석종(Chung, Seok Jong) ORCID logo https://orcid.org/0000-0001-6086-3199
홍진용(Hong, Jin Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88920
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