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Factors related to outcomes of subthalamic deep brain stimulation in Parkinson’s disease

Authors
 Hae Yu Kim  ;  Won Seok Chang  ;  Dong Wan Kang  ;  Young Ho Sohn  ;  Myung Sik Lee  ;  Jin Woo Chang 
Citation
 JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, Vol.54(2) : 118-124, 2013 
Journal Title
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
ISSN
 2005-3711 
Issue Date
2013
Keywords
Deep brain stimulation ; Parkinson's disease ; Subthalamic nucleus
Abstract
OBJECTIVE:
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment of choice for patients with advanced idiopathic Parkinson's disease (PD) who have motor complication with medication. The objectives of this study are to analyze long-term follow-up data of STN DBS cases and to identify the factors related to outcomes.
METHODS:
Fifty-two PD patients who underwent STN DBS were followed-up for more than 3 years. The Unified Parkinsons Disease Rating Scale (UPDRS) and other clinical profiles were assessed preoperatively and during follow-up. A linear regression model was used to analyze whether factors predict the results of STN DBS. We divided the study individuals into subgroups according to several factors and compared subgroups.
RESULTS:
Preoperative activity of daily living (ADL) and the magnitude of preoperative levodopa response were shown to predict the improvement in UPDRS part II without medication, and preoperative ADL and levodopa equivalent dose (LED) were shown to predict the improvement in UPDRS part II with medication. In UPDRS part III with medication, the magnitude of preoperative levodopa response was a predicting factor.
CONCLUSION:
The intensity of preoperative levodopa response was a strong factor for motor outcome. And preoperative ADL and LED were strong factors for ADL improvement. More vigorous studies should be conducted to elucidate how levodopa-induced motor complications are ameliorated after STN DBS.
Files in This Item:
T201305286.pdf Download
DOI
10.3340/jkns.2013.54.2.118
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Dong Wan(강동완)
Kim, Hae Yu(김해유)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88907
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