Cited 27 times in
Clinical characteristics and insulin independence of Koreans with new-onset type 2 diabetes presenting with diabetic ketoacidosis
DC Field | Value | Language |
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dc.contributor.author | 이병완 | - |
dc.date.accessioned | 2014-12-18T09:49:05Z | - |
dc.date.available | 2014-12-18T09:49:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1520-7552 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88887 | - |
dc.description.abstract | BACKGROUND: We evaluated the incidence, characteristics and insulin independence of Koreans with new-onset type 2 diabetes (T2D) initially presenting with diabetic ketoacidosis (DKA). METHODS: We analysed clinical and biochemical data from diabetic patients presenting with DKA. They were classified into ketosis-prone diabetes (KPD) type 1A (KPD-T1A) (A+β-), type 1B (KPD-T1B) (A-β-), type 2A (KPD-T2A) (A+β+) or type 2B (KPD-T2B) (A-β+) according to the presence or absence of an autoantibody and β-cell reserve. Changes in therapy after insulin discontinuation were evaluated for up to 4 years. We also compared clinical and biochemical characteristics between newly diagnosed T2D patients presenting with DKA and previously diagnosed T2D patients presenting with DKA. RESULTS: Among 60 newly diagnosed KPD patients, 18, 21 and 21 patients were classified as KPD-T1A, KPD-T1B and KPD-T2B, respectively. In the KPD-T2B group, both fasting and stimulated C-peptide were recovered over 6 months. After 4 years of DKA development, 75% of KPD-T2B subjects no longer required insulin. Compared with previously diagnosed T2D patients presenting with DKA, newly diagnosed KPD-T2B patients tended to be younger, more obese and showed better insulin secretory function after recovery from DKA. CONCLUSIONS: New-onset T2D patients presenting with DKA was not uncommon among the Korean population. In contrast to previously diagnosed T2D patients presenting with DKA, who showed a progressive decrease in insulin secretory function, new-onset KPD-T2B patients recovered insulin secretory function over time, and insulin independence could be expected. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | DIABETES-METABOLISM RESEARCH AND REVIEWS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asian Continental Ancestry Group/statistics & numerical data | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/complications | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/drug therapy* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/epidemiology* | - |
dc.subject.MESH | Diabetic Ketoacidosis/drug therapy* | - |
dc.subject.MESH | Diabetic Ketoacidosis/epidemiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Insulin/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Withholding Treatment/statistics & numerical data | - |
dc.subject.MESH | Young Adult | - |
dc.title | Clinical characteristics and insulin independence of Koreans with new-onset type 2 diabetes presenting with diabetic ketoacidosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | H. Seok | - |
dc.contributor.googleauthor | C. H. Jung | - |
dc.contributor.googleauthor | B-W. Lee | - |
dc.contributor.googleauthor | J. H. Kim | - |
dc.contributor.googleauthor | W. J. Lee | - |
dc.contributor.googleauthor | M. J. Lee | - |
dc.contributor.googleauthor | S. W. Kim | - |
dc.identifier.doi | 10.1002/dmrr.2421 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02796 | - |
dc.relation.journalcode | J00725 | - |
dc.identifier.eissn | 1520-7560 | - |
dc.identifier.pmid | 23653323 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/dmrr.2421/abstract | - |
dc.subject.keyword | diabetes mellitus | - |
dc.subject.keyword | insulin secretion | - |
dc.subject.keyword | ketoacidosis | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 507 | - |
dc.citation.endPage | 513 | - |
dc.identifier.bibliographicCitation | DIABETES-METABOLISM RESEARCH AND REVIEWS, Vol.29(6) : 507-513, 2013 | - |
dc.identifier.rimsid | 33886 | - |
dc.type.rims | ART | - |
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