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Increased Lymphocyte Infiltration in Rheumatoid Arthritis Is Correlated with an Increase in LTi-like Cells in Synovial Fluid

DC Field Value Language
dc.contributor.author김경수-
dc.date.accessioned2014-12-18T09:47:48Z-
dc.date.available2014-12-18T09:47:48Z-
dc.date.issued2013-
dc.identifier.issn1598-2629-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88846-
dc.description.abstractIn this study, we compared the immune cell populations in rheumatoid arthritis (RA) synovial fluid, which shows lymphoid tissue-like structure, with those in tonsils, which are normal secondary lymphoid tissues. Firstly, we found that CD4-CD11b+ macrophages were the major population in RA synovial fluid and that B cells were the major population in tonsils. In addition, synovial fluid from patients with osteoarthritis, which is a degenerative joint disease, contained CD4+CD11b+ monocytes as the major immune cell population. Secondly, we categorized three groups based on the proportion of macrophages found in RA synovial fluid: (1) the macrophage-high group, which contained more than 80% macrophages; (2) the macrophage-intermediate group, which contained between 40% and 80% macrophages; and (3) the macrophage-low group, which contained less than 40% macrophages. In the macrophage-low group, more lymphoid tissue inducer (LTi)-like cells were detected, and the expression of OX40L and TRANCE in these cells was higher than that in the other groups. In addition, in this group, the suppressive function of regulatory T cells was downregulated. Finally, CXCL13 expression was higher in RA synovial fluid than in tonsils, but CCL21 expression was comparable in synovial fluid from all groups and in tonsils. These data demonstrate that increased lymphocyte infiltration in RA synovial fluid is correlated with an increase in LTi-like cells and the elevation of the chemokine expression.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorea Society for Immunology : Korean Society of Biological Response Modifiers-
dc.relation.isPartOfIMMUNE NETWORK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIncreased Lymphocyte Infiltration in Rheumatoid Arthritis Is Correlated with an Increase in LTi-like Cells in Synovial Fluid-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorJihye Koo-
dc.contributor.googleauthorSoochan Kim-
dc.contributor.googleauthorWoong Jae Jung-
dc.contributor.googleauthorYe Eun Lee-
dc.contributor.googleauthorGwan Gyu Song-
dc.contributor.googleauthorKyung-Su Kim-
dc.contributor.googleauthorMi-Yeon Kim-
dc.identifier.doi10.4110/in.2013.13.6.240-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00298-
dc.relation.journalcodeJ01033-
dc.identifier.eissn2092-6685-
dc.identifier.pmid24385942-
dc.subject.keywordLymphoid tissue inducer-
dc.subject.keywordRheumatoid arthritis-
dc.subject.keywordTonsil-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.affiliatedAuthorKim, Kyung Su-
dc.rights.accessRightsfree-
dc.citation.volume13-
dc.citation.number6-
dc.citation.startPage240-
dc.citation.endPage248-
dc.identifier.bibliographicCitationIMMUNE NETWORK, Vol.13(6) : 240-248, 2013-
dc.identifier.rimsid33661-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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