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High serum CA19-9 levels are associated with an increased risk of cholangiocarcinoma in patients with intrahepatic duct stones: a case–control study

DC FieldValueLanguage
dc.contributor.author이우정-
dc.contributor.author정문재-
dc.contributor.author정재복-
dc.contributor.author조중현-
dc.contributor.author김경식-
dc.contributor.author박승우-
dc.contributor.author박정엽-
dc.contributor.author방승민-
dc.contributor.author송시영-
dc.date.accessioned2014-12-18T09:46:59Z-
dc.date.available2014-12-18T09:46:59Z-
dc.date.issued2013-
dc.identifier.issn0930-2794-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88820-
dc.description.abstractBACKGROUND: Hepatolithiasis is a known risk factor for cholangiocarcinoma (CC). Due to the high risk of complications that accompany endoscopic and surgical stone removal, it is often difficult to decide whether it is beneficial to remove intrahepatic ductal stones. We conducted a case-control study to determine the risk of developing CC and the benefit of stone removal in patients with hepatolithiasis. METHODS: Twenty-three patients with CC group between 2002 and 2012 were included in this study. For each patient with CC, four control patients with hepatolithiasis were enrolled based on age and sex matching. Finally, 115 patients with hepatolithiasis were enrolled. RESULTS: The mean length of time that intrahepatic stones were present was 116.57 (± 98.77) months in the CC group and 80.56 (± 101.10) months in the control group. History of gastrectomy [OR 5.756 (1.329-24.930), p = 0.019], history of choledochoenterostomy (OR 4.938 [1.129-21.595], p = 0.034), serum CA19-9 level [OR 1.001 (1.000-1.001), p = 0.022], and complete removal of stones [OR 0.167 (0.052-0.539), p = 0.003] were independent predictive factors of CC. In patients who had undergone incomplete removal of stones, the occurrence of CC was significantly reduced overall as well as in a subgroup of patients with elevated CA19-9 (p = 0.015 and p = 0.006, respectively) compared to patients with a CA19-9 of <22 U/mL (p = 0.477). CONCLUSIONS: History of gastrectomy or choledochoenterostomy, high levels of serum CA19-9, and incomplete removal of stones were potential predictive factors of CC in patients with hepatolithiasis. Additionally, complete removal of stones may reduce the risk of CC in patients with high serum CA19-9 levels (>22 U/mL).-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfSURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntigens, Tumor-Associated, Carbohydrate/blood*-
dc.subject.MESHBile Duct Neoplasms/blood*-
dc.subject.MESHBile Duct Neoplasms/diagnosis-
dc.subject.MESHBile Duct Neoplasms/epidemiology*-
dc.subject.MESHBile Ducts, Intrahepatic-
dc.subject.MESHBiomarkers, Tumor/blood*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCausality-
dc.subject.MESHCholangiocarcinoma/blood*-
dc.subject.MESHCholangiocarcinoma/diagnosis-
dc.subject.MESHCholangiocarcinoma/epidemiology*-
dc.subject.MESHComorbidity-
dc.subject.MESHFemale-
dc.subject.MESHGallstones/blood-
dc.subject.MESHGallstones/diagnosis-
dc.subject.MESHGallstones/epidemiology*-
dc.subject.MESHGallstones/surgery-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHRisk Factors-
dc.titleHigh serum CA19-9 levels are associated with an increased risk of cholangiocarcinoma in patients with intrahepatic duct stones: a case–control study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung Hyun Jo-
dc.contributor.googleauthorMoon Jae Chung-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorSeungmin Bang-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorJae Bock Chung-
dc.identifier.doi10.1007/s00464-013-3025-1-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03602-
dc.contributor.localIdA03706-
dc.contributor.localIdA03912-
dc.contributor.localIdA00299-
dc.contributor.localIdA01551-
dc.contributor.localIdA01647-
dc.contributor.localIdA01786-
dc.contributor.localIdA02035-
dc.contributor.localIdA02993-
dc.relation.journalcodeJ02703-
dc.identifier.eissn1432-2218-
dc.identifier.pmid23760942-
dc.identifier.urlhttp://dx.doi.org/10.1007/s00464-013-3025-1-
dc.subject.keywordHepatolithiasis-
dc.subject.keywordCholangiocarcinoma-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameChung, Moon Jae-
dc.contributor.alternativeNameChung, Jae Bock-
dc.contributor.alternativeNameJo, Jung Hyun-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNamePark, Jeong Youp-
dc.contributor.alternativeNameBang, Seung Min-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.affiliatedAuthorChung, Moon Jae-
dc.contributor.affiliatedAuthorChung, Jae Bock-
dc.contributor.affiliatedAuthorJo, Jung Hyun-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorPark, Jeong Youp-
dc.contributor.affiliatedAuthorBang, Seung Min-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.rights.accessRightsnot free-
dc.citation.volume27-
dc.citation.number11-
dc.citation.startPage4210-
dc.citation.endPage4216-
dc.identifier.bibliographicCitationSURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol.27(11) : 4210-4216, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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