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Different CXCR4 Expression According to Various Histologic Subtype of Papillary Thyroid Carcinoma

Authors
 Dong Yeob Shin  ;  Kwang Joon Kim  ;  Cheol Ryong Ku  ;  Mi Kyung Lee  ;  Soo Il Jee  ;  Woong Youn Chung  ;  Eun Jig Lee 
Citation
 ENDOCRINE PATHOLOGY, Vol.24(4) : 169-176, 2013 
Journal Title
 ENDOCRINE PATHOLOGY 
ISSN
 1046-3976 
Issue Date
2013
MeSH
Adult ; Carcinoma, Papillary/metabolism* ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary, Follicular/metabolism* ; Carcinoma, Papillary, Follicular/pathology ; Female ; Humans ; Male ; Middle Aged ; Receptors, CXCR4/metabolism* ; Thyroid Gland/metabolism* ; Thyroid Gland/pathology ; Thyroid Neoplasms/metabolism* ; Thyroid Neoplasms/pathology
Keywords
Papillary Thyroid Carcinoma ; CXCR4 ; Chemokine Receptor ; Immunohistochemistry ; Tissue Microarray
Abstract
Functional chemokine (C-X-C motif) receptor 4 (CXCR4) is well known to be over-expressed in papillary thyroid carcinoma (PTC). The aim of this study was to evaluate whether or not the expression of CXCR4 is different by histological subtypes of PTC and to elucidate the relationship between the expression of CXCR4 and clinicopathologic factors. CXCR4 expression in 127 PTC samples was assessed using immunohistochemical staining. The expression of CXCR4 showed different patterns according to the histological subtype of PTC (p < 0.001). A strong expression of CXCR4 was observed more frequently in the poorly differentiated region of PTC (81.0 %) than in classical PTC (50.0 %). Strong CXCR4 expression was less frequently shown in follicular variant (33.9 %) and in diffuse sclerosing variant (14.3 %) of PTC. CXCR4 expression showed a distinct pattern according to the histological subtype of PTC although not associated with other clinicopathological parameters.
Full Text
http://link.springer.com/article/10.1007%2Fs12022-013-9259-6
DOI
10.1007/s12022-013-9259-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Cheol Ryong(구철룡) ORCID logo https://orcid.org/0000-0001-8693-9630
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Shin, Dong Yeob(신동엽) ORCID logo https://orcid.org/0000-0003-1048-7978
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Chung, Woung Youn(정웅윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88794
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