Cited 26 times in
Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 조한별 | - |
dc.date.accessioned | 2014-12-18T09:42:28Z | - |
dc.date.available | 2014-12-18T09:42:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1354-750X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88675 | - |
dc.description.abstract | OBJECTIVE: We investigated the clinical significance of ERp57 in the progression of cervical cancer. METHODS: mRNA and protein expression of ERp57 in cervical neoplasias were examined. RESULTS: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018). CONCLUSIONS: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOMARKERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/metabolism* | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/mortality | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/pathology | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Down-Regulation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Protein Disulfide-Isomerases/genetics* | - |
dc.subject.MESH | Protein Disulfide-Isomerases/metabolism | - |
dc.subject.MESH | Protein Transport | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.subject.MESH | Uterine Cervical Neoplasms/metabolism* | - |
dc.subject.MESH | Uterine Cervical Neoplasms/mortality | - |
dc.subject.MESH | Uterine Cervical Neoplasms/pathology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Hyunsoo Chung | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Candice Perry | - |
dc.contributor.googleauthor | Jaekyung Song | - |
dc.contributor.googleauthor | Kris Ylaya | - |
dc.contributor.googleauthor | Heejeong Lee | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.identifier.doi | 10.3109/1354750X.2013.827742 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A03921 | - |
dc.relation.journalcode | J00311 | - |
dc.identifier.eissn | 1366-5804 | - |
dc.identifier.pmid | 23957851 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/1354750X.2013.827742 | - |
dc.subject.keyword | Cervical cancer | - |
dc.subject.keyword | ERp57 | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | survival | - |
dc.subject.keyword | tissue microarray | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 573 | - |
dc.citation.endPage | 579 | - |
dc.identifier.bibliographicCitation | BIOMARKERS, Vol.18(7) : 573-579, 2013 | - |
dc.identifier.rimsid | 33402 | - |
dc.type.rims | ART | - |
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