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Peripheral zone prostate-specific antigen density: an effective parameter for prostate cancer prediction in men receiving 5α-reductase inhibitors

DC FieldValueLanguage
dc.contributor.author이승환-
dc.contributor.author정병하-
dc.contributor.author구교철-
dc.contributor.author이동훈-
dc.date.accessioned2014-12-18T09:41:38Z-
dc.date.available2014-12-18T09:41:38Z-
dc.date.issued2013-
dc.identifier.issn2287-8882-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88649-
dc.description.abstractPURPOSE: To evaluate the predictive performance of various parameters derived from volume-adjusted prostate-specific antigen (PSA) values in detecting prostate cancer (PCa) and high-grade (Gleason score≥7) PCa according to treatment with a 5α-reductase inhibitor (5ARI). METHODS: The results of 3,520 prostate biopsies performed between May 2006 and January 2013 were retrospectively assessed. With adjustment for age, 291 patients who had received 5ARI treatment for more than 6 months were identified and matched 1:3 to patients naïve to 5ARIs, resulting in a total of 873 patients. Peripheral zone (PZ) and transition zone (TZ) volumes were determined by transrectal ultrasonography. Receiver-operating characteristic (ROC) curve analysis was used to compare predictive performances of PSA, PSA density (PSAD; PSA/prostate volume), PZPSAD (PSA/PZ volume), and TZPSAD (PSA/TZ volume) for detecting PCa and high-grade PCa for each group. RESULTS: The area under the ROC curve (AUC) was higher for PSAD than for PSA in the 5ARI group (0.751 vs. 0.677) and in the 5ARI-naïve group (0.649 vs. 0.582), respectively (P<0.001). In the 5ARI group, the AUC for PZPSAD was even higher than that for PSAD (0.781 vs. 0.751, P=0.038); in the 5ARI-naïve group, however, PZPSAD failed to achieve significant superiority (0.652 vs. 0.649, P=0.321). All volume-adjusted PSA indexes showed higher predictive accuracies for detecting PCa than did PSA in both groups. For detecting high-grade cancer, PZPSAD also revealed the highest predictive value in the 5ARI group, whereas PSA revealed the highest predictive value in the 5ARI-naïve group. CONCLUSIONS: The diagnostic performance of PSAD in the detection of PCa is superior to that of PSA. For patients receiving 5ARI for more than 6 months, PZPSAD confers additional benefits for detecting both PCa and high-grade PCa.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPROSTATE INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePeripheral zone prostate-specific antigen density: an effective parameter for prostate cancer prediction in men receiving 5α-reductase inhibitors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorKyo Chul Koo-
dc.contributor.googleauthorDong Hoon Lee-
dc.contributor.googleauthorSeung Hwan Lee-
dc.contributor.googleauthorByung Ha Chung-
dc.identifier.doi10.12954/PI.13022-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02938-
dc.contributor.localIdA02742-
dc.contributor.localIdA03607-
dc.contributor.localIdA00188-
dc.relation.journalcodeJ02559-
dc.identifier.eissn2287-903X-
dc.identifier.pmid24223410-
dc.subject.keywordDensity-
dc.subject.keywordProstate cancer-
dc.subject.keywordProstate-specific antigen-
dc.contributor.alternativeNameLee, Seung Hwan-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.alternativeNameKoo, Kyo Chul-
dc.contributor.alternativeNameLee, Dong Hoon-
dc.contributor.affiliatedAuthorLee, Seung Hwan-
dc.contributor.affiliatedAuthorLee, Dong Hoon-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.contributor.affiliatedAuthorKoo, Kyo Chul-
dc.rights.accessRightsfree-
dc.citation.volume1-
dc.citation.number3-
dc.citation.startPage102-
dc.citation.endPage108-
dc.identifier.bibliographicCitationPROSTATE INTERNATIONAL, Vol.1(3) : 102-108, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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