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Peripheral zone prostate-specific antigen density: an effective parameter for prostate cancer prediction in men receiving 5α-reductase inhibitors
DC Field | Value | Language |
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dc.contributor.author | 이승환 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 구교철 | - |
dc.contributor.author | 이동훈 | - |
dc.date.accessioned | 2014-12-18T09:41:38Z | - |
dc.date.available | 2014-12-18T09:41:38Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2287-8882 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88649 | - |
dc.description.abstract | PURPOSE: To evaluate the predictive performance of various parameters derived from volume-adjusted prostate-specific antigen (PSA) values in detecting prostate cancer (PCa) and high-grade (Gleason score≥7) PCa according to treatment with a 5α-reductase inhibitor (5ARI). METHODS: The results of 3,520 prostate biopsies performed between May 2006 and January 2013 were retrospectively assessed. With adjustment for age, 291 patients who had received 5ARI treatment for more than 6 months were identified and matched 1:3 to patients naïve to 5ARIs, resulting in a total of 873 patients. Peripheral zone (PZ) and transition zone (TZ) volumes were determined by transrectal ultrasonography. Receiver-operating characteristic (ROC) curve analysis was used to compare predictive performances of PSA, PSA density (PSAD; PSA/prostate volume), PZPSAD (PSA/PZ volume), and TZPSAD (PSA/TZ volume) for detecting PCa and high-grade PCa for each group. RESULTS: The area under the ROC curve (AUC) was higher for PSAD than for PSA in the 5ARI group (0.751 vs. 0.677) and in the 5ARI-naïve group (0.649 vs. 0.582), respectively (P<0.001). In the 5ARI group, the AUC for PZPSAD was even higher than that for PSAD (0.781 vs. 0.751, P=0.038); in the 5ARI-naïve group, however, PZPSAD failed to achieve significant superiority (0.652 vs. 0.649, P=0.321). All volume-adjusted PSA indexes showed higher predictive accuracies for detecting PCa than did PSA in both groups. For detecting high-grade cancer, PZPSAD also revealed the highest predictive value in the 5ARI group, whereas PSA revealed the highest predictive value in the 5ARI-naïve group. CONCLUSIONS: The diagnostic performance of PSAD in the detection of PCa is superior to that of PSA. For patients receiving 5ARI for more than 6 months, PZPSAD confers additional benefits for detecting both PCa and high-grade PCa. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PROSTATE INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Peripheral zone prostate-specific antigen density: an effective parameter for prostate cancer prediction in men receiving 5α-reductase inhibitors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Dong Hoon Lee | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.identifier.doi | 10.12954/PI.13022 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02938 | - |
dc.contributor.localId | A02742 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A00188 | - |
dc.relation.journalcode | J02559 | - |
dc.identifier.eissn | 2287-903X | - |
dc.identifier.pmid | 24223410 | - |
dc.subject.keyword | Density | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | Prostate-specific antigen | - |
dc.contributor.alternativeName | Lee, Seung Hwan | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.alternativeName | Lee, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Koo, Kyo Chul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 1 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 102 | - |
dc.citation.endPage | 108 | - |
dc.identifier.bibliographicCitation | PROSTATE INTERNATIONAL, Vol.1(3) : 102-108, 2013 | - |
dc.identifier.rimsid | 33383 | - |
dc.type.rims | ART | - |
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