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Effects of single-dose dexmedetomidine on the quality of recovery after modified radical mastectomy: a randomised contraolled trial
DC Field | Value | Language |
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dc.contributor.author | 김신형 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 오영준 | - |
dc.contributor.author | 최용선 | - |
dc.date.accessioned | 2014-12-18T09:41:34Z | - |
dc.date.available | 2014-12-18T09:41:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0375-9393 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88647 | - |
dc.description.abstract | Background: Dexmedetomidine is a highly selective α2 agonist with analgesic, anxiolytic, and anti-inflammatory properties. We investigated the effect of a single dose of dexmedetomidine on patient-perceived quality of recovery and clinical recovery variables after modified radical mastectomy under general anesthesia in this randomized, double-blind, placebo-controlled study. Methods: After Institutional Review Board approval, ninety two female patients were randomly allocated to receive intravenously either saline (Group C, N.=46) or 0.5 μg/kg of dexmedetomidine (Group D, N.=46) five min before the end of surgery. The quality of recovery was assessed using a 40-item quality-of-recovery scoring system (QoR-40) preoperatively and 24 h after surgery. Pain intensity, rescue analgesics, and postoperative nausea and vomiting (PONV) were assessed at postanesthesia care unit (PACU), 1-6 h, and 6-24 h after surgery. Results: Postoperative global QoR-40 scores were higher in Group D compared with Group C (181 [175-187] vs. 174 [154.5-181.5], P=0.004); postoperative QoR-40 scores were improved in the dimensions of emotional state, physical comfort, and psychological support. Total amount of tramadol during 24 h after surgery was significantly lower in Group D than in Group C (54 vs. 76 mg, P=0.006). The incidence of PONV was lower in Group D than in Group C in PACU (21% vs. 43%, P=0.026) and 6-24 h period after surgery (10% vs. 41%, P=0.012). Heart rate and mean blood pressure were significantly lower in Group D as compared with Group C at 5 min after administration of dexmedetomidine, 1 min after extubation, and 20 min after arrival in PACU. Conclusion: The use of a single dose dexmedetomidine improved the quality of recovery and reduced analgesic requirements and the incidence of PONV in the early postoperative period after modified radical mastectomy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | MINERVA ANESTESIOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analgesics, Non-Narcotic/administration & dosage* | - |
dc.subject.MESH | Anesthesia Recovery Period* | - |
dc.subject.MESH | Dexmedetomidine/administration & dosage* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mastectomy, Modified Radical* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Young Adult | - |
dc.title | Effects of single-dose dexmedetomidine on the quality of recovery after modified radical mastectomy: a randomised contraolled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Kim S. H. | - |
dc.contributor.googleauthor | Oh Y. J. | - |
dc.contributor.googleauthor | Park B. W. | - |
dc.contributor.googleauthor | Sim J. | - |
dc.contributor.googleauthor | Choi Y. S. | - |
dc.identifier.doi | 23698545 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00676 | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A02389 | - |
dc.contributor.localId | A04119 | - |
dc.relation.journalcode | J02235 | - |
dc.identifier.eissn | 1827-1596 | - |
dc.identifier.pmid | 23698545 | - |
dc.identifier.url | http://www.minervamedica.it/en/journals/minerva-anestesiologica/article.php?cod=R02Y2013N11A1248 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Analgesics, Non-Narcotic/administration & dosage* | - |
dc.subject.keyword | Anesthesia Recovery Period* | - |
dc.subject.keyword | Dexmedetomidine/administration & dosage* | - |
dc.subject.keyword | Double-Blind Method | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Mastectomy, Modified Radical* | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Young Adult | - |
dc.contributor.alternativeName | Kim, Shin Hyung | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Oh, Young Jun | - |
dc.contributor.alternativeName | Choi, Yong Seon | - |
dc.contributor.affiliatedAuthor | Kim, Shin Hyung | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Oh, Young Jun | - |
dc.contributor.affiliatedAuthor | Choi, Yong Seon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 79 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1248 | - |
dc.citation.endPage | 1258 | - |
dc.identifier.bibliographicCitation | MINERVA ANESTESIOLOGICA, Vol.79(11) : 1248-1258, 2013 | - |
dc.identifier.rimsid | 33382 | - |
dc.type.rims | ART | - |
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