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Effect of TGF-ß RII mutation on TGF-ß signaling
DC Field | Value | Language |
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dc.contributor.author | 김진 | - |
dc.contributor.author | 손화경 | - |
dc.date.accessioned | 2014-12-18T09:41:03Z | - |
dc.date.available | 2014-12-18T09:41:03Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2233-9299 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88632 | - |
dc.description.abstract | We have previously reported I170T mutation of transforming growth factor- ß receptor II (TßR-II) in human oral squamous cell carcinoma samples. To analyze the functional consequences of I170T TßR-II mutation, we performed co-immunoprecipitation of TßR-II with TßR-I and determined intracellular signaling activities of TßR-II. As a result, either wild type or I170T mutant TßR-II was coprecipitated with TßR-I, regardless of TGF-ß and both wild-type and I170T mutant TßR-II exhibited similar levels of transcriptional activities upon treatment of TGF-ß1. Moreover, I170T TßR-II localized at the cell membrane similar to wild-type TßR-II. Our data showed that I170T mutation of TßR-II does not affect the receptor oligomerization, membrane localization, and downstream signaling upon binding of TGF-ß1. Taken together, these results indicate that I170T mutation of TßR-II does not change structural or physiological characteristics of TßR-II, raising the possibility that I170T might be a new SNP of TßR-II. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | Journal of Convergence Information Technology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of TGF-ß RII mutation on TGF-ß signaling | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학) | - |
dc.contributor.googleauthor | Iha Park | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.contributor.googleauthor | Hwa-Kyung Son | - |
dc.contributor.googleauthor | Youn-Soo Shim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02003 | - |
dc.contributor.localId | A01009 | - |
dc.relation.journalcode | J01353 | - |
dc.identifier.pmid | TGF-ß1 ; TßR-II Mutation ; SNP | - |
dc.subject.keyword | TGF-ß1 | - |
dc.subject.keyword | TßR-II Mutation | - |
dc.subject.keyword | SNP | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.alternativeName | Son, Hwa Kyung | - |
dc.contributor.affiliatedAuthor | Son, Hwa Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 387 | - |
dc.citation.endPage | 392 | - |
dc.identifier.bibliographicCitation | Journal of Convergence Information Technology, Vol.8(14) : 387-392, 2013 | - |
dc.identifier.rimsid | 33369 | - |
dc.type.rims | ART | - |
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