Cited 11 times in
Expression of cell metabolism-related genes in different molecular subtypes of triple-negative breast cancer
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2014-12-18T09:40:10Z | - |
dc.date.available | 2014-12-18T09:40:10Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0300-8916 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88604 | - |
dc.description.abstract | Aims and background. We evaluated the difference in and significance of cancer cell metabolism by molecular subtyping of triple-negative breast carcinoma. Methods. Tissue microarrays from 122 surgical specimens of triple-negative breast carcinoma patients and immunohistochemical staining for CK5/6, epidermal growth factor receptor, claudin 3, claudin 4, claudin 7, E-cadherin, androgen receptor, and gamma-glutamyltransferase 1 were used to classify triple-negative breast carcinoma as follows: basal-like type, molecular apocrine type, claudin low type, mixed type and null type. In addition, immunohistochemical staining for metabolism-related proteins such as c-myc, insulin-like growth factor (g)-1, hypoxia-inducible factor 1-1?, glucose transporter 1, carbonic anhydrase IX antibody, macrophage migration inhibitory factor, and pyruvate dehydrogenase kinase 1 was used to compare the differences according to molecular subtype and clinicopathological factors. Results. The basal-like type showed the highest proportion of high glucose transporter 1 expression (P = 0.049) and carbonic anhydrase IX antibody expression (P = 0.008). Hypoxia-inducible factor 1-1? expression was associated with lymph node metastasis (P = 0.001) and central fibrotic zone (P = 0.012), and high glucose transporter 1 expression was related to high histologic grade (P = 0.007), cytokeratin 5/6 positivity (P = 0.002), and central fibrotic zone (P = 0.017). Finally, carbonic anhydrase IX antibody was associated with cytokeratin 5/6 positivity (P = 0.001) and central fibrotic zone (P = 0.048). Conclusions. Our study revealed the different characteristics of cancer cell metabolism according to the molecular subtypes of triple-negative breast carcinoma. Among them, basal-like type was the most glycolytic and acid-resistant phenotype. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | TUMORI J | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, Neoplasm/analysis | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Carbonic Anhydrase IX | - |
dc.subject.MESH | Carbonic Anhydrases/analysis | - |
dc.subject.MESH | DNA-Binding Proteins/analysis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | GeneExpressionRegulation, Neoplastic | - |
dc.subject.MESH | Glucose Transporter Type 1/analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1, alpha Subunit/analysis | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Insulin-Like Growth Factor I/analysis | - |
dc.subject.MESH | Intramolecular Oxidoreductases/analysis | - |
dc.subject.MESH | Macrophage Migration-Inhibitory Factors/analysis | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/analysis | - |
dc.subject.MESH | Transcription Factors/analysis | - |
dc.subject.MESH | Triple NegativeBreastNeoplasms/chemistry* | - |
dc.subject.MESH | Triple NegativeBreastNeoplasms/mortality | - |
dc.subject.MESH | Triple NegativeBreastNeoplasms/pathology | - |
dc.title | Expression of cell metabolism-related genes in different molecular subtypes of triple-negative breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Hyae Min Jeon | - |
dc.contributor.googleauthor | Do Hee Kim | - |
dc.contributor.googleauthor | Woo-Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1700/1361.15110 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J02764 | - |
dc.identifier.eissn | 2038-2529 | - |
dc.identifier.pmid | 24326847 | - |
dc.identifier.url | http://www.tumorionline.it/articoli.php?archivio=yes&vol_id=1361&id=15110 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Antigens, Neoplasm/analysis | - |
dc.subject.keyword | Biomarkers, Tumor/analysis* | - |
dc.subject.keyword | Carbonic Anhydrase IX | - |
dc.subject.keyword | Carbonic Anhydrases/analysis | - |
dc.subject.keyword | DNA-Binding Proteins/analysis | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | GeneExpressionRegulation, Neoplastic | - |
dc.subject.keyword | Glucose Transporter Type 1/analysis | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hypoxia-Inducible Factor 1, alpha Subunit/analysis | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Insulin-Like Growth Factor I/analysis | - |
dc.subject.keyword | Intramolecular Oxidoreductases/analysis | - |
dc.subject.keyword | Macrophage Migration-Inhibitory Factors/analysis | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Neoplasm Grading | - |
dc.subject.keyword | Neoplasm Staging | - |
dc.subject.keyword | Phenotype | - |
dc.subject.keyword | Protein-Serine-Threonine Kinases/analysis | - |
dc.subject.keyword | Transcription Factors/analysis | - |
dc.subject.keyword | Triple NegativeBreastNeoplasms/chemistry* | - |
dc.subject.keyword | Triple NegativeBreastNeoplasms/mortality | - |
dc.subject.keyword | Triple NegativeBreastNeoplasms/pathology | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 99 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 555 | - |
dc.citation.endPage | 564 | - |
dc.identifier.bibliographicCitation | TUMORI J, Vol.99(4) : 555-564, 2013 | - |
dc.identifier.rimsid | 33348 | - |
dc.type.rims | ART | - |
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