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Expression of cell metabolism-related genes in different molecular subtypes of triple-negative breast cancer

DC FieldValueLanguage
dc.contributor.author구자승-
dc.contributor.author정우희-
dc.date.accessioned2014-12-18T09:40:10Z-
dc.date.available2014-12-18T09:40:10Z-
dc.date.issued2013-
dc.identifier.issn0300-8916-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88604-
dc.description.abstractAims and background. We evaluated the difference in and significance of cancer cell metabolism by molecular subtyping of triple-negative breast carcinoma. Methods. Tissue microarrays from 122 surgical specimens of triple-negative breast carcinoma patients and immunohistochemical staining for CK5/6, epidermal growth factor receptor, claudin 3, claudin 4, claudin 7, E-cadherin, androgen receptor, and gamma-glutamyltransferase 1 were used to classify triple-negative breast carcinoma as follows: basal-like type, molecular apocrine type, claudin low type, mixed type and null type. In addition, immunohistochemical staining for metabolism-related proteins such as c-myc, insulin-like growth factor (g)-1, hypoxia-inducible factor 1-1?, glucose transporter 1, carbonic anhydrase IX antibody, macrophage migration inhibitory factor, and pyruvate dehydrogenase kinase 1 was used to compare the differences according to molecular subtype and clinicopathological factors. Results. The basal-like type showed the highest proportion of high glucose transporter 1 expression (P = 0.049) and carbonic anhydrase IX antibody expression (P = 0.008). Hypoxia-inducible factor 1-1? expression was associated with lymph node metastasis (P = 0.001) and central fibrotic zone (P = 0.012), and high glucose transporter 1 expression was related to high histologic grade (P = 0.007), cytokeratin 5/6 positivity (P = 0.002), and central fibrotic zone (P = 0.017). Finally, carbonic anhydrase IX antibody was associated with cytokeratin 5/6 positivity (P = 0.001) and central fibrotic zone (P = 0.048). Conclusions. Our study revealed the different characteristics of cancer cell metabolism according to the molecular subtypes of triple-negative breast carcinoma. Among them, basal-like type was the most glycolytic and acid-resistant phenotype.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTUMORI J-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, Neoplasm/analysis-
dc.subject.MESHBiomarkers, Tumor/analysis*-
dc.subject.MESHCarbonic Anhydrase IX-
dc.subject.MESHCarbonic Anhydrases/analysis-
dc.subject.MESHDNA-Binding Proteins/analysis-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHGlucose Transporter Type 1/analysis-
dc.subject.MESHHumans-
dc.subject.MESHHypoxia-Inducible Factor 1, alpha Subunit/analysis-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInsulin-Like Growth Factor I/analysis-
dc.subject.MESHIntramolecular Oxidoreductases/analysis-
dc.subject.MESHMacrophage Migration-Inhibitory Factors/analysis-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPhenotype-
dc.subject.MESHProtein-Serine-Threonine Kinases/analysis-
dc.subject.MESHTranscription Factors/analysis-
dc.subject.MESHTriple Negative Breast Neoplasms/chemistry*-
dc.subject.MESHTriple Negative Breast Neoplasms/mortality-
dc.subject.MESHTriple Negative Breast Neoplasms/pathology-
dc.titleExpression of cell metabolism-related genes in different molecular subtypes of triple-negative breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorHyae Min Jeon-
dc.contributor.googleauthorDo Hee Kim-
dc.contributor.googleauthorWoo-Hee Jung-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi10.1700/1361.15110-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ02764-
dc.identifier.eissn2038-2529-
dc.identifier.pmid24326847-
dc.identifier.urlhttp://www.tumorionline.it/articoli.php?archivio=yes&vol_id=1361&id=15110-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordAntigens, Neoplasm/analysis-
dc.subject.keywordBiomarkers, Tumor/analysis*-
dc.subject.keywordCarbonic Anhydrase IX-
dc.subject.keywordCarbonic Anhydrases/analysis-
dc.subject.keywordDNA-Binding Proteins/analysis-
dc.subject.keywordFemale-
dc.subject.keywordGene Expression Regulation, Neoplastic-
dc.subject.keywordGlucose Transporter Type 1/analysis-
dc.subject.keywordHumans-
dc.subject.keywordHypoxia-Inducible Factor 1, alpha Subunit/analysis-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordInsulin-Like Growth Factor I/analysis-
dc.subject.keywordIntramolecular Oxidoreductases/analysis-
dc.subject.keywordMacrophage Migration-Inhibitory Factors/analysis-
dc.subject.keywordMiddle Aged-
dc.subject.keywordNeoplasm Grading-
dc.subject.keywordNeoplasm Staging-
dc.subject.keywordPhenotype-
dc.subject.keywordProtein-Serine-Threonine Kinases/analysis-
dc.subject.keywordTranscription Factors/analysis-
dc.subject.keywordTriple Negative Breast Neoplasms/chemistry*-
dc.subject.keywordTriple Negative Breast Neoplasms/mortality-
dc.subject.keywordTriple Negative Breast Neoplasms/pathology-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsnot free-
dc.citation.volume99-
dc.citation.number4-
dc.citation.startPage555-
dc.citation.endPage564-
dc.identifier.bibliographicCitationTUMORI J, Vol.99(4) : 555-564, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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