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Role of splenectomy in patients with hepatocellular carcinoma and hypersplenism

DC FieldValueLanguage
dc.contributor.author김경식-
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author안상훈-
dc.contributor.author임진홍-
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.date.accessioned2014-12-18T09:39:30Z-
dc.date.available2014-12-18T09:39:30Z-
dc.date.issued2013-
dc.identifier.issn1445-1433-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88583-
dc.description.abstractINTRODUCTION: Hypersplenism with thrombocytopenia is a common complication of cirrhosis with portal hypertension. We evaluated the role of splenectomy in patients with hepatocellular carcinoma (HCC) in terms of the improvement of biochemical indices and liver volume. METHODS: Nineteen patients with HCC underwent liver resection and splenectomy from January 2000 to December 2009. Thirty-nine patients who underwent liver resection during the same period were enrolled as case-matched controls. We performed a retrospective review of prospectively collected data. We analysed the results of biochemical tests, disease-free survival and overall survival and measured the liver volume before and at 90 days after operation. RESULTS: Preoperative white blood cell counts (P = 0.001), platelet counts (P = 0.021), total bilirubin (P ≤ 0.001) and prothrombin time by international normalized ratio (P = 0.043) were significantly different. However, these results had converged to similar levels 90 days after the operation. The degree of increment in liver volume were similar (P = 0.763). In splenectomy group, portal vein thrombosis developed in eight patients and all patients except one recovered using only conservative treatments. There was an operative mortality because of liver failure by thrombosis. CONCLUSIONS: Although splenectomy may induce thrombosis, liver failure and subsequent mortality, splenectomy may improve liver function and expand the indication of liver resection if postoperative management is conducted conservatively.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANZ JOURNAL OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/complications-
dc.subject.MESHCarcinoma, Hepatocellular/mortality-
dc.subject.MESHCarcinoma, Hepatocellular/surgery*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypersplenism-
dc.subject.MESHHypertension, Portal/complications-
dc.subject.MESHLiver/pathology-
dc.subject.MESHLiver Neoplasms/complications-
dc.subject.MESHLiver Neoplasms/mortality-
dc.subject.MESHLiver Neoplasms/surgery*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrgan Size-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSplenectomy*-
dc.titleRole of splenectomy in patients with hepatocellular carcinoma and hypersplenism-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorSung Hoon Kim-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorJin Hong Lim-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorKyung Sik Kim-
dc.identifier.doi10.1111/j.1445-2197.2012.06241.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00299-
dc.contributor.localIdA00654-
dc.contributor.localIdA02226-
dc.contributor.localIdA03411-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00193-
dc.identifier.eissn1445-2197-
dc.identifier.pmid22985446-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1445-2197.2012.06241.x/abstract-
dc.subject.keywordcirrhosis-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordhypersplenism-
dc.subject.keywordsplenectomy-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLim, Jin Hong-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLim, Jin Hong-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsnot free-
dc.citation.volume83-
dc.citation.number11-
dc.citation.startPage865-
dc.citation.endPage870-
dc.identifier.bibliographicCitationANZ JOURNAL OF SURGERY, Vol.83(11) : 865-870, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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