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Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study

Authors
 Hyangkyu Lee  ;  Sang Hui Chu  ;  Jae Yeo Park  ;  Hyun Ki Park  ;  Jee Aee Im  ;  Ji Won Lee 
Citation
 Endocrine Journal, Vol.60(11) : 1269-1273, 2013 
Journal Title
 Endocrine Journal 
ISSN
 0918-8959 
Issue Date
2013
MeSH
Adiponectin/blood ; Adiposity/genetics* ; Adult ; Body Mass Index ; Cross-Sectional Studies ; Female ; Gene Expression ; Healthy Volunteers ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/metabolism* ; Leukocytes, Mononuclear/metabolism* ; Lipid Metabolism ; Male ; Pilot Projects ; RNA, Messenger/metabolism ; Regression Analysis ; Sirtuin 1/genetics* ; Sirtuin 1/metabolism* ; Tomography, X-Ray Computed ; Waist Circumference
Keywords
SIRT1 ; Visceral fat ; Obesity
Abstract
Sirtuin1 (SIRT1) is activated during calorie restriction and appears to be related to energy balance through glucose or lipid metabolism and insulin signaling. These findings suggest that SIRT1 may play a role in the pathophysiology of visceral obesity. Therefore, we investigated the relationship between SIRT1 gene expression in circulating peripheral blood mononuclear cells (PBMCs) and abdominal visceral adiposity as measured by computed tomography. We recruited 43 men and women without history of diabetes or cardiovascular disease Biomarkers of metabolic disease and body composition by computed tomography were assessed. SIRT1 gene expression was determined using isolated PBMCs. SIRT1 expression levels negatively correlated with body mass index, waist circumference, abdominal visceral fat area, and homeostasis model of assessment of insulin resistance (HOMA-IR) and positively correlated with adiponectin levels. Results of step-wise multiple regression analysis revealed that abdominal visceral fat area and HOMA-IR were independently associated with SIRT1 expression. The significant association between abdominal visceral fat accumulation and SIRT1 gene expression in PBMCs suggests that SIRT1 may be a new therapeutic target for the prevention of disease related to obesity, especially visceral obesity.
Files in This Item:
T201304145.pdf Download
DOI
10.1507/endocrj.EJ13-0207
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
Lee, Hyang Kyu(이향규) ORCID logo https://orcid.org/0000-0002-0821-6020
Chu, Sang Hui(추상희) ORCID logo https://orcid.org/0000-0001-6877-5599
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88572
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