298 794

Cited 10 times in

Inflammatory Responses in the Muscle Coat of Stomach and Small Bowel in the Postoperative Ileus Model of Guinea Pig

DC Field Value Language
dc.contributor.author이영호-
dc.contributor.author최홍규-
dc.contributor.author박종필-
dc.contributor.author박효진-
dc.date.accessioned2014-12-18T09:37:59Z-
dc.date.available2014-12-18T09:37:59Z-
dc.date.issued2013-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88536-
dc.description.abstractPURPOSE: Small intestinal function returns first after surgery, and then the function of the stomach returns to normal after postoperative ileus (POI). The aim of this study was to investigate inflammatory responses in the muscle coat of stomach and small intestine in guinea pig POI model. MATERIALS AND METHODS: The distance of charcoal migration from pylorus to the distal intestine was measured. Hematoxylin and eosin (H&E) and immunohistochemical stain for calprotectin were done from the histologic sections of stomach, jejunum and ileum obtained at 3 and 6 hour after operation. Data were compared between sham operation and POI groups. RESULTS: The distance of charcoal migration was significantly reduced in the 3 and 6 hour POI groups compared with sham operated groups (p<0.05). On H&E staining, the degree of inflammation was significantly higher in the stomach of 3 hour POI groups compared with jejunum and ileum of POI groups or sham operated groups (p<0.05). Calprotectin positive cells were significantly increased in the muscle coat of stomach of 3 hour POI groups compared with jejunum and ileum of POI groups or sham operated groups (p<0.05). There was strong association between the degree of inflammation and calprotectin positive cells in stomach. CONCLUSION: Postoperative ileus induced by cecal manipulation significantly increased the degree of inflammation and calprotectin positive cells in the muscle coat of stomach as a remote organ. The relevance of degree of inflammation and the recovery time of ileus should be pursued in the future research.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCharcoal-
dc.subject.MESHGuinea Pigs-
dc.subject.MESHIleus/immunology*-
dc.subject.MESHMale-
dc.subject.MESHMuscle, Smooth/immunology*-
dc.subject.MESHStomach/immunology*-
dc.titleInflammatory Responses in the Muscle Coat of Stomach and Small Bowel in the Postoperative Ileus Model of Guinea Pig-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHong Kyu Choi-
dc.contributor.googleauthorYoung Ho Lee-
dc.contributor.googleauthorJong Pil Park-
dc.contributor.googleauthorKevin Min-
dc.contributor.googleauthorHyojin Park-
dc.identifier.doi10.3349/ymj.2013.54.6.1336-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02968-
dc.contributor.localIdA04222-
dc.contributor.localIdA01665-
dc.contributor.localIdA01774-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24142636-
dc.subject.keywordPostoperative ileus-
dc.subject.keywordcalprotectin-
dc.subject.keywordsmall intestine-
dc.subject.keywordstomach-
dc.contributor.alternativeNameLee, Young Ho-
dc.contributor.alternativeNameChoi, Hong Kyu-
dc.contributor.alternativeNamePark, Jong Pil-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.affiliatedAuthorLee, Young Ho-
dc.contributor.affiliatedAuthorChoi, Hong Kyu-
dc.contributor.affiliatedAuthorPark, Jong Pil-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.rights.accessRightsfree-
dc.citation.volume54-
dc.citation.number6-
dc.citation.startPage1336-
dc.citation.endPage1341-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.54(6) : 1336-1341, 2013-
dc.identifier.rimsid34370-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.