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Sagittal Abdominal Diameter Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Incident Peritoneal Dialysis Patients

DC FieldValueLanguage
dc.contributor.author이미정-
dc.contributor.author최규헌-
dc.contributor.author한승혁-
dc.contributor.author강신욱-
dc.contributor.author고광일-
dc.contributor.author구향모-
dc.contributor.author김승준-
dc.contributor.author김찬호-
dc.contributor.author도화미-
dc.contributor.author박정탁-
dc.contributor.author오형중-
dc.contributor.author유동은-
dc.contributor.author유태현-
dc.date.accessioned2014-12-18T09:37:30Z-
dc.date.available2014-12-18T09:37:30Z-
dc.date.issued2013-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88521-
dc.description.abstractBACKGROUNDS AND AIMS: Visceral fat has a crucial role in the development and progression of cardiovascular disease, the major cause of death in end-stage renal disease (ESRD). Although sagittal abdominal diameter (SAD), as an index of visceral fat, significantly correlated with mortality in the general population, the impact of SAD on clinical outcomes has never been explored in ESRD patients. Therefore, we sought to elucidate the prognostic value of SAD in incident peritoneal dialysis (PD) patients. METHODS: We prospectively determined SAD by lateral abdominal X-ray at PD initiation, and evaluated the association of SAD with all-cause and cardiovascular mortality in 418 incident PD patients. RESULTS: The mean SAD was 24.5 ± 4.3 cm, and during a mean follow-up of 39.4 months, 97 patients (23.2%) died, and 49.4% of them died due to cardiovascular disease. SAD was a significant independent predictor of all-cause [3rd versus 1st tertile, HR (hazard ratio): 3.333, 95% CI (confidence interval): 1.514-7.388, P = 0.01; per 1 cm increase, HR: 1.071, 95% CI: 1.005-1.141, P = 0.03] and cardiovascular mortality (3rd versus 1st tertile, HR: 8.021, 95% CI: 1.994-32.273, P = 0.01; per 1 cm increase, HR: 1.106, 95% CI: 1.007-1.214, P = 0.03). Multivariate fractional polynomial analysis also showed that all-cause and cardiovascular mortality risk increased steadily with higher SAD values. In addition, SAD provided higher predictive value for all-cause (AUC: 0.691 vs. 0.547, P<0.001) and cardiovascular mortality (AUC: 0.644 vs. 0.483, P<0.001) than body mass index (BMI). Subgroup analysis revealed higher SAD (≥ 24.2 cm) was significantly associated with all-cause mortality in men, women, younger patients (<65 years), and patients with lower BMI (<22.3 kg/m(2)). CONCLUSIONS: SAD determined by lateral abdominal X-ray at PD initiation was a significant independent predictor of all-cause and cardiovascular mortality in incident PD patients. Estimating visceral fat by SAD could be useful to stratify mortality risk in these patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSagittal Abdominal Diameter Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Incident Peritoneal Dialysis Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorDong Ho Shin-
dc.contributor.googleauthorSeung Jun Kim-
dc.contributor.googleauthorDong Eun Yoo-
dc.contributor.googleauthorKwang Il Ko-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorChan Ho Kim-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi10.1371/journal.pone.0077082-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04043-
dc.contributor.localIdA04304-
dc.contributor.localIdA00053-
dc.contributor.localIdA00110-
dc.contributor.localIdA00203-
dc.contributor.localIdA01037-
dc.contributor.localIdA01315-
dc.contributor.localIdA01654-
dc.contributor.localIdA02097-
dc.contributor.localIdA02417-
dc.contributor.localIdA02461-
dc.contributor.localIdA02526-
dc.contributor.localIdA00659-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ02540-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKo, Kwang Il-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameKim, Seung Jun-
dc.contributor.alternativeNameKim, Chan Ho-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Dong Eun-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKo, Kwang Il-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorKim, Chan Ho-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Dong Eun-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorKim, Seung Jun-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number10-
dc.citation.startPagee77082-
dc.identifier.bibliographicCitationPLoS One, Vol.8(10) : e77082, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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