Cited 29 times in
Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: a murine model
DC Field | Value | Language |
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dc.contributor.author | 윤주헌 | - |
dc.date.accessioned | 2014-12-18T09:37:12Z | - |
dc.date.available | 2014-12-18T09:37:12Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88512 | - |
dc.description.abstract | Cell death is a critical host response to regulate the fate of bacterial infections, innate immune responses, and ultimately, disease outcome. Shigella spp. invade and colonize gut epithelium in human and nonhuman primates but adult mice are naturally resistant to intra-gastric Shigella infection. In this study, however, we found Shigella could invade the terminal ileum of the mouse small intestine by 1 hour after infection and be rapidly cleared within 24 h. These early phase events occurred shortly after oral infection resulting in epithelial shedding, degranulation of Paneth cells, and cell death in the intestine. During this process, autophagy proceeded without any signs of inflammation. In contrast, blocking autophagy in epithelial cells enhanced host cell death, leading to tissue destruction and to inflammation, suggesting that autophagic flow relieves cellular stress associated with host cell death and inflammation. Herein we propose a new concept of “epithelial barrier turnover” as a general intrinsic host defense mechanism that increases survival of host cells and inhibits inflammation against enteric bacterial infections, which is regulated by autophagy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Autophagy/genetics* | - |
dc.subject.MESH | Bacterial Load | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Dysentery, Bacillary/immunology* | - |
dc.subject.MESH | Dysentery, Bacillary/microbiology | - |
dc.subject.MESH | Dysentery, Bacillary/pathology | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Host-Pathogen Interactions | - |
dc.subject.MESH | Immunity, Innate* | - |
dc.subject.MESH | Inflammation/immunology | - |
dc.subject.MESH | Inflammation/microbiology | - |
dc.subject.MESH | Inflammation/pathology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Paneth Cells/immunology | - |
dc.subject.MESH | Paneth Cells/microbiology | - |
dc.subject.MESH | Paneth Cells/pathology* | - |
dc.subject.MESH | Peyer's Patches/immunology | - |
dc.subject.MESH | Peyer's Patches/microbiology | - |
dc.subject.MESH | Peyer's Patches/pathology* | - |
dc.subject.MESH | Shigella flexneri/immunology* | - |
dc.title | Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: a murine model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Sun-Young Chang | - |
dc.contributor.googleauthor | Se-Na Lee | - |
dc.contributor.googleauthor | Jin-Young Yang | - |
dc.contributor.googleauthor | Dong Wook Kim | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Hyun-Jeong Ko | - |
dc.contributor.googleauthor | Michinaga Ogawa | - |
dc.contributor.googleauthor | Chihiro Sasakawa | - |
dc.contributor.googleauthor | Mi-Na Kweon | - |
dc.identifier.doi | 10.1371/journal.pone.0081095 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02604 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24260541 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Autophagy/genetics* | - |
dc.subject.keyword | Bacterial Load | - |
dc.subject.keyword | Cell Survival | - |
dc.subject.keyword | Dysentery, Bacillary/immunology* | - |
dc.subject.keyword | Dysentery, Bacillary/microbiology | - |
dc.subject.keyword | Dysentery, Bacillary/pathology | - |
dc.subject.keyword | Gene Expression Profiling | - |
dc.subject.keyword | Gene Expression Regulation | - |
dc.subject.keyword | Host-Pathogen Interactions | - |
dc.subject.keyword | Immunity, Innate* | - |
dc.subject.keyword | Inflammation/immunology | - |
dc.subject.keyword | Inflammation/microbiology | - |
dc.subject.keyword | Inflammation/pathology | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred C57BL | - |
dc.subject.keyword | Paneth Cells/immunology | - |
dc.subject.keyword | Paneth Cells/microbiology | - |
dc.subject.keyword | Paneth Cells/pathology* | - |
dc.subject.keyword | Peyer's Patches/immunology | - |
dc.subject.keyword | Peyer's Patches/microbiology | - |
dc.subject.keyword | Peyer's Patches/pathology* | - |
dc.subject.keyword | Shigella flexneri/immunology* | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | e81095 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.8(11) : e81095, 2013 | - |
dc.identifier.rimsid | 34355 | - |
dc.type.rims | ART | - |
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