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Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia

Authors
 Ok-Hee Lee  ;  Jayoung Kim  ;  Jin-Moo Kim  ;  Hyunji Lee  ;  Eun Hee Kim  ;  Soo-Kyung Bae  ;  Youngsok Choi  ;  Hyo Suk Nam  ;  Ji Hoe Heo 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.438(2) : 388-394, 2013 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2013
Keywords
Brain ischemia ; High mobility group box-1 ; Oxygen/glucose deprivation ; Sirtuin 6
Abstract
Sirtuin 6 (SIRT6) belongs to the sirtuin family of NAD+-dependent deacetylases and has been implicated in the regulation of metabolism, inflammation, and aging. Here, we found that SIRT6 was predominantly expressed in neuronal cells throughout the entire brain. Ischemia models using transient middle cerebral artery occlusion in rats and oxygen/glucose deprivation (OGD) in SH-SY5Y neuronal cells showed that ischemia reduced SIRT6 expression and induced the release of high mobility group box-1 (HMGB1) from cell nuclei. The reduced expression of SIRT6 via treatment with SIRT6 siRNA dramatically enhanced the OGD-induced release of HMGB1 in SH-SY5Y cells. Together, our data suggest that SIRT6 may serve as a potential therapeutic target for HMGB1-mediated inflammation after cerebral ischemia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X13012473
DOI
10.1016/j.bbrc.2013.07.085
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Ja Young(김자영)
Kim, Jin Moo(김진무)
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Lee, Ok Hee(이옥희)
Lee, Hyun Ji(이현지)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88485
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