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Final height and insulin-like growth factor-1 in children with medulloblastoma treated with growth hormone

DC Field Value Language
dc.contributor.author권아름-
dc.contributor.author김덕희-
dc.contributor.author김동석-
dc.contributor.author김호성-
dc.contributor.author채현욱-
dc.date.accessioned2014-12-18T09:34:49Z-
dc.date.available2014-12-18T09:34:49Z-
dc.date.issued2013-
dc.identifier.issn0256-7040-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88436-
dc.description.abstractPURPOSE: Medulloblastoma is a highly malignant childhood brain tumor. Survival from medulloblastoma is increasing. This study was performed to examine growth outcomes, insulin-like growth factor-1(IGF-1), and response to growth hormone (GH) treatment in children with medulloblastoma. METHODS: Retrospective analysis of 34 children treated with GH for medulloblastoma was performed. We evaluated serum IGF-1 and insulin-like growth factor binding protein-3 concentrations. Further, we examined growth status and changes with GH treatment according to treatment modality. RESULTS: GH deficiency was observed in 28 patients (82 %). The initial height at the start of GH treatment was -2.35 ± -1.53 standard deviation score (SDS) and increased to -1.85 ± -1.28 SDS by 1 year, -1.64 ± -1.46 SDS by 2 years, and -1.42 ± -1.49 SDS by 3 years after GH treatment. The final height was -1.54 ± -1.06 SDS. Gender, surgical method, tumor location, tumor size, and type of radiation did not correlate with height gain. A younger age at the initiation of GH treatment correlated with height gain. The initial serum IGF-1 concentration was -1.73 ± -0.42 and increased significantly to -0.74 ± -0.21 SDS by 1 year after GH treatment. The serum IGF-1 SDS increment correlated significantly with height gain. CONCLUSIONS: Beginning GH treatment at a younger age was an important prognostic factor for growth outcome. Serum IGF-1 increment correlated with height gain during GH treatment. Thus, early GH treatment and analysis of serum IGF-1 might be helpful for improving final height or growth outcome.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCHILDS NERVOUS SYSTEM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFinal height and insulin-like growth factor-1 in children with medulloblastoma treated with growth hormone-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorHyun Wook Chae-
dc.contributor.googleauthorYoung Seok Park-
dc.contributor.googleauthorDong Seok Kim-
dc.contributor.googleauthorAh Reum Kwon-
dc.contributor.googleauthorHo-Seong Kim-
dc.contributor.googleauthorDuk Hee Kim-
dc.identifier.doi10.1007/s00381-013-2124-6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00228-
dc.contributor.localIdA00378-
dc.contributor.localIdA00402-
dc.contributor.localIdA01184-
dc.contributor.localIdA04026-
dc.relation.journalcodeJ00525-
dc.identifier.eissn1433-0350-
dc.identifier.pmidMedulloblastoma ; Growth hormone ; Final height ; Insulin-like growth factor-1-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00381-013-2124-6-
dc.subject.keywordMedulloblastoma-
dc.subject.keywordGrowth hormone-
dc.subject.keywordFinal height-
dc.subject.keywordInsulin-like growth factor-1-
dc.contributor.alternativeNameKwon, Ah Reum-
dc.contributor.alternativeNameKim, Duk Hee-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.alternativeNameKim, Ho Seong-
dc.contributor.alternativeNameChae, Hyun Wook-
dc.contributor.affiliatedAuthorKwon, Ah Reum-
dc.contributor.affiliatedAuthorKim, Duk Hee-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.contributor.affiliatedAuthorKim, Ho Seong-
dc.contributor.affiliatedAuthorChae, Hyun Wook-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number10-
dc.citation.startPage1859-
dc.citation.endPage1863-
dc.identifier.bibliographicCitationCHILDS NERVOUS SYSTEM, Vol.29(10) : 1859-1863, 2013-
dc.identifier.rimsid34033-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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