Cited 5 times in
Final height and insulin-like growth factor-1 in children with medulloblastoma treated with growth hormone
DC Field | Value | Language |
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dc.contributor.author | 권아름 | - |
dc.contributor.author | 김덕희 | - |
dc.contributor.author | 김동석 | - |
dc.contributor.author | 김호성 | - |
dc.contributor.author | 채현욱 | - |
dc.date.accessioned | 2014-12-18T09:34:49Z | - |
dc.date.available | 2014-12-18T09:34:49Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0256-7040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88436 | - |
dc.description.abstract | PURPOSE: Medulloblastoma is a highly malignant childhood brain tumor. Survival from medulloblastoma is increasing. This study was performed to examine growth outcomes, insulin-like growth factor-1(IGF-1), and response to growth hormone (GH) treatment in children with medulloblastoma. METHODS: Retrospective analysis of 34 children treated with GH for medulloblastoma was performed. We evaluated serum IGF-1 and insulin-like growth factor binding protein-3 concentrations. Further, we examined growth status and changes with GH treatment according to treatment modality. RESULTS: GH deficiency was observed in 28 patients (82 %). The initial height at the start of GH treatment was -2.35 ± -1.53 standard deviation score (SDS) and increased to -1.85 ± -1.28 SDS by 1 year, -1.64 ± -1.46 SDS by 2 years, and -1.42 ± -1.49 SDS by 3 years after GH treatment. The final height was -1.54 ± -1.06 SDS. Gender, surgical method, tumor location, tumor size, and type of radiation did not correlate with height gain. A younger age at the initiation of GH treatment correlated with height gain. The initial serum IGF-1 concentration was -1.73 ± -0.42 and increased significantly to -0.74 ± -0.21 SDS by 1 year after GH treatment. The serum IGF-1 SDS increment correlated significantly with height gain. CONCLUSIONS: Beginning GH treatment at a younger age was an important prognostic factor for growth outcome. Serum IGF-1 increment correlated with height gain during GH treatment. Thus, early GH treatment and analysis of serum IGF-1 might be helpful for improving final height or growth outcome. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CHILDS NERVOUS SYSTEM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Final height and insulin-like growth factor-1 in children with medulloblastoma treated with growth hormone | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.contributor.googleauthor | Young Seok Park | - |
dc.contributor.googleauthor | Dong Seok Kim | - |
dc.contributor.googleauthor | Ah Reum Kwon | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.contributor.googleauthor | Duk Hee Kim | - |
dc.identifier.doi | 10.1007/s00381-013-2124-6 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00228 | - |
dc.contributor.localId | A00378 | - |
dc.contributor.localId | A00402 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J00525 | - |
dc.identifier.eissn | 1433-0350 | - |
dc.identifier.pmid | Medulloblastoma ; Growth hormone ; Final height ; Insulin-like growth factor-1 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00381-013-2124-6 | - |
dc.subject.keyword | Medulloblastoma | - |
dc.subject.keyword | Growth hormone | - |
dc.subject.keyword | Final height | - |
dc.subject.keyword | Insulin-like growth factor-1 | - |
dc.contributor.alternativeName | Kwon, Ah Reum | - |
dc.contributor.alternativeName | Kim, Duk Hee | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.alternativeName | Kim, Ho Seong | - |
dc.contributor.alternativeName | Chae, Hyun Wook | - |
dc.contributor.affiliatedAuthor | Kwon, Ah Reum | - |
dc.contributor.affiliatedAuthor | Kim, Duk Hee | - |
dc.contributor.affiliatedAuthor | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Ho Seong | - |
dc.contributor.affiliatedAuthor | Chae, Hyun Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1859 | - |
dc.citation.endPage | 1863 | - |
dc.identifier.bibliographicCitation | CHILDS NERVOUS SYSTEM, Vol.29(10) : 1859-1863, 2013 | - |
dc.identifier.rimsid | 34033 | - |
dc.type.rims | ART | - |
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