Cited 18 times in
Inhibition of tumor growth and histopathological changes following treatment with a chemokine receptor CXCR4 antagonist in a prostate cancer xenograft model
DC Field | Value | Language |
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dc.contributor.author | 이주용 | - |
dc.contributor.author | 조강수 | - |
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2014-12-18T09:27:39Z | - |
dc.date.available | 2014-12-18T09:27:39Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88211 | - |
dc.description.abstract | The stromal derived factor-1 (SDF-1)/CXCR4 axis is associated with tumor aggressiveness and metastasis in prostate cancer. The present study aimed to explore the potential therapeutic effects of a CXCR4 antagonist in prostate cancer. The effect of SDF-1 and a CXCR4-specific antagonist, AMD3100, on human prostate cancer PC-3 cell proliferation and protein kinase B (Akt) signaling was assessed. Moreover, a PC-3 tumor xenograft model was used to evaluate the effect of AMD3100 on tumor growth and to identify the histopathological changes and immunohistochemical differences between AMD3100-treated and untreated groups. Cell proliferation was not significantly affected by SDF-1 or AMD3100 treatment in vitro. Western blot analysis revealed that SDF-1 stimulation enhanced the expression of phosphorylated Akt in the PC-3 cells, but that the SDF-1-induced expression of phosphorylated Akt was abrogated in the AMD3100-treated PC-3 cells. In the PC-3 tumor xenograft model, AMD3100 significantly inhibited tumor growth, while AMD3100-treated PC-3 tumors had lower levels of microvessel formation and a lower immunoreactivity for the proliferation marker Ki-67 and the anti-apoptotic marker Bcl-2 compared to control tumors in vivo. The CXCR4-specific antagonist inhibits SDF-1-induced CXCR4/Akt signal transduction, and effectively suppresses tumor growth in the PC-3 xenograft model. The present study indicates that CXCR4 targeting may represent a novel strategy for the treatment of castration-resistant prostate cancer (CRPC). | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Inhibition of tumor growth and histopathological changes following treatment with a chemokine receptor CXCR4 antagonist in a prostate cancer xenograft model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | KANG SU CHO | - |
dc.contributor.googleauthor | SO JUNG YOON | - |
dc.contributor.googleauthor | JOO YONG LEE | - |
dc.contributor.googleauthor | NAM HOON CHO | - |
dc.contributor.googleauthor | YOUNG DEUK CHOI | - |
dc.contributor.googleauthor | YUN SEOB SONG | - |
dc.contributor.googleauthor | SUNG JOON HONG | - |
dc.identifier.doi | 10.3892/ol.2013.1515 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03161 | - |
dc.contributor.localId | A03801 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02417 | - |
dc.identifier.eissn | 1792-1082 | - |
dc.identifier.pmid | 24137439 | - |
dc.subject.keyword | CXCL12 | - |
dc.subject.keyword | CXCR4 | - |
dc.subject.keyword | chemokine | - |
dc.subject.keyword | prostatic neoplasms | - |
dc.subject.keyword | receptors | - |
dc.contributor.alternativeName | Lee, Joo Yong | - |
dc.contributor.alternativeName | Cho, Kang Su | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Lee, Joo Yong | - |
dc.contributor.affiliatedAuthor | Cho, Kang Su | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 6 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 933 | - |
dc.citation.endPage | 938 | - |
dc.identifier.bibliographicCitation | ONCOLOGY LETTERS, Vol.6(4) : 933-938, 2013 | - |
dc.identifier.rimsid | 33127 | - |
dc.type.rims | ART | - |
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