Cited 19 times in
Tumor Volume Adds Prognostic Value in Patients with Organ-Confined Prostate Cancer
DC Field | Value | Language |
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dc.contributor.author | 강대용 | - |
dc.contributor.author | 김광현 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 신태영 | - |
dc.contributor.author | 임세이캣 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 한웅규 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2014-12-18T09:27:25Z | - |
dc.date.available | 2014-12-18T09:27:25Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88204 | - |
dc.description.abstract | PURPOSE: This study was designed to assess the independent prognostic value of tumor volume (TV) and whether adding TV provides additional prognostic information for predicting biochemical recurrence (BCR) after radical prostatectomy. METHODS: We reviewed the medical records of 1,129 patients who underwent radical prostatectomy between July 2005 and July 2011. TV was categorized as minimal (≤1.0 ml), moderate (1.1-5.0 ml), or extensive (>5.0 ml). Cox regression analysis was performed to identify independent predictors of BCR. The predictive accuracies of Cox's proportional hazard regression models with and without TV were quantified and compared using time-dependent receiver operating characteristic curve analysis. RESULTS: Increasing TV was associated with higher prostate specific antigen, pathological Gleason score, and pathologic tumor stage. TV was an independent predictor of BCR in multivariate analysis (p<0.001). When patients were stratified by organ-confined and nonorgan-confined tumor groups, TV remained an independent predictor of BCR in organ-confined tumors (p<0.001). In the nonorgan-confined tumor group, a significant difference was found only between extensive versus minimal TV (p=0.023). The predictive accuracy of the Cox regression model increased significantly by adding TV in organ-confined tumor group (0.748 vs. 0.704, p<0.05) but not in nonorgan-confined group (0.742 vs. 0.734, p>0.05). CONCLUSIONS: TV was an independent prognostic predictor of BCR in organ-confined prostate cancers and provided additional prognostic information with increased predictive accuracy. In contrast, TV did not increase the predictive accuracy in nonorgan-confined tumor. TV should be considered as a prognosticator in organ-confined tumors. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Recurrence, Local/diagnosis* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/surgery | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prostatectomy* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology* | - |
dc.subject.MESH | Prostatic Neoplasms/surgery | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tumor Burden* | - |
dc.title | Tumor Volume Adds Prognostic Value in Patients with Organ-Confined Prostate Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Kwang Hyun Kim | - |
dc.contributor.googleauthor | Sey Kiat Lim | - |
dc.contributor.googleauthor | Tae-Young Shin | - |
dc.contributor.googleauthor | Dae Ryong Kang | - |
dc.contributor.googleauthor | Woong Kyu Han | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.identifier.doi | 10.1245/s10434-013-3016-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00009 | - |
dc.contributor.localId | A00319 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A02168 | - |
dc.contributor.localId | A03371 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A04308 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 23720069 | - |
dc.identifier.url | http://link.springer.com/article/10.1245%2Fs10434-013-3016-4 | - |
dc.subject.keyword | Tumour Volume | - |
dc.subject.keyword | Prostate Specific Antigen | - |
dc.subject.keyword | Radical Prostatectomy | - |
dc.subject.keyword | Gleason Score | - |
dc.subject.keyword | Predictive Accuracy | - |
dc.contributor.alternativeName | Kang, Dae Ryong | - |
dc.contributor.alternativeName | Kim, Kwang Hyun | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.alternativeName | Shin, Tae Young | - |
dc.contributor.alternativeName | Lim, Sey Kiat | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Han, Woong Kyu | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Kang, Dae Ryong | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Hyun | - |
dc.contributor.affiliatedAuthor | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | Shin, Tae Young | - |
dc.contributor.affiliatedAuthor | Lim, Sey Kiat | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Han, Woong Kyu | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 20 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 3133 | - |
dc.citation.endPage | 3139 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.20(9) : 3133-3139, 2013 | - |
dc.identifier.rimsid | 33122 | - |
dc.type.rims | ART | - |
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