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Effects of Beraprost Sodium on Subjective Symptoms in Diabetic Patients with Peripheral Arterial Disease

DC FieldValueLanguage
dc.contributor.author윤항섭-
dc.contributor.author이진우-
dc.contributor.author최우진-
dc.date.accessioned2014-12-18T09:26:36Z-
dc.date.available2014-12-18T09:26:36Z-
dc.date.issued2013-
dc.identifier.issn2005-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88179-
dc.description.abstractBACKGROUND: This study evaluated the effects of Beraprost sodium (Berasil) on subjective leg symptoms in patients with peripheral arterial disease caused by diabetes mellitus. METHODS: Ninety-four diabetic patients with peripheral arterial disease were treated with Beraprost in a fixed-dose, prospective, multicenter, cohort study. Beraprost (40 µg) was administered orally 3 times daily (120 µg/day) for 12 weeks. We developed a new disease-specific symptom questionnaire, which evaluated the effect of peripheral arterial disease on leg discomfort in daily life and assessed therapeutic responses to treatment. Patients were asked for their subjective assessment of symptoms on a written questionnaire before treatment and after 12 weeks of therapy. RESULTS: There was significant improvement in all estimated subjective symptoms (burning, coldness, edema, exertional pain, stabbing, and paresthesias) in the lower extremities at 12 weeks (p < 0.001). There were 18 patients with neuropathy in whom significant improvement was noted for 6 subjective symptoms at 12 weeks (p < 0.05). Adverse events considered to be drug-related were observed in 4 patients (4.3%), all of which were mild and resolved with discontinuation of the medication. CONCLUSIONS: Beraprost is effective as a treatment for improving various subjective symptoms in the lower extremities, such as burning, coldness, edema, exertional pain, stabbing, and paresthesias, in diabetic patients with peripheral arterial disease.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICOECONOMICS AND OUTCOMES RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCohort Studies-
dc.subject.MESHDiabetes Complications/drug therapy*-
dc.subject.MESHDiabetes Complications/physiopathology-
dc.subject.MESHEpoprostenol/analogs & derivatives*-
dc.subject.MESHEpoprostenol/therapeutic use-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeripheral Arterial Disease/complications-
dc.subject.MESHPeripheral Arterial Disease/drug therapy*-
dc.subject.MESHPlatelet Aggregation Inhibitors/therapeutic use*-
dc.subject.MESHProspective Studies-
dc.subject.MESHStatistics, Nonparametric-
dc.titleEffects of Beraprost Sodium on Subjective Symptoms in Diabetic Patients with Peripheral Arterial Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthorHang Seob Yoon-
dc.contributor.googleauthorWoo Jin Choi-
dc.contributor.googleauthorIl Hoon Sung-
dc.contributor.googleauthorHo Seong Lee-
dc.contributor.googleauthorHyung Jin Chung-
dc.contributor.googleauthorJin Woo Lee-
dc.identifier.doi10.4055/cios.2013.5.2.145-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04121-
dc.contributor.localIdA02619-
dc.contributor.localIdA03230-
dc.relation.journalcodeJ00620-
dc.identifier.eissn2005-4408-
dc.identifier.pmid23730480-
dc.subject.keywordBeraprost sodium-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordIntermittent claudication-
dc.subject.keywordPeripheral arterial disease-
dc.subject.keywordProstaglandin I2-
dc.contributor.alternativeNameYoon, Hang Seob-
dc.contributor.alternativeNameLee, Jin Woo-
dc.contributor.alternativeNameChoi, Woo Jin-
dc.contributor.affiliatedAuthorChoi, Woo Jin-
dc.contributor.affiliatedAuthorYoon, Hang Seob-
dc.contributor.affiliatedAuthorLee, Jin Woo-
dc.rights.accessRightsfree-
dc.citation.volume5-
dc.citation.number2-
dc.citation.startPage145-
dc.citation.endPage151-
dc.identifier.bibliographicCitationCLINICOECONOMICS AND OUTCOMES RESEARCH, Vol.5(2) : 145-151, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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