Cited 32 times in
Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs
DC Field | Value | Language |
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dc.contributor.author | 이윤한 | - |
dc.date.accessioned | 2014-12-18T09:26:31Z | - |
dc.date.available | 2014-12-18T09:26:31Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88177 | - |
dc.description.abstract | Aberrantly activated signal transducer and activator of transcription (STAT) proteins are implicated with human cancers and represent essential roles for cancer cell survival and proliferation. Therefore, the development of small-molecule inhibitors of STAT signaling bearing pharmacological activity has therapeutic potential for the treatment of human cancers. In this study, we identified sophoraflavanone G as a novel small-molecule inhibitor of STAT signaling in human cancer cells. Sophoraflavanone G inhibited tyrosine phosphorylation of STAT proteins in Hodgkin's lymphoma and tyrosine phosphorylation of STAT3 in solid cancer cells by inhibiting phosphorylation of the Janus kinase (JAK) proteins, Src family tyrosine kinases, such as Lyn and Src, Akt, and ERK1/2. In addition, sophoraflavanone G inhibited STAT5 phosphorylation in murine-bone-marrow-derived pro-B cells transfected with translocated Ets Leukemia (TEL)-JAKs and cytokine-induced rat pre-T lymphoma cells, as well as STAT5b reporter activity in TEL-JAKs and STAT5b reporter systems. Sophoraflavanone G also inhibited nuclear factor-κB (NF-κB) signaling in multiple myeloma cells. Furthermore, sophoraflavanone G inhibited cancer cell proliferation and induced apoptosis by regulating the expression of apoptotic and anti-apoptotic proteins. Our data suggest that sophoraflavanone G is a novel small-molecule inhibitor of STAT signaling by targeting upstream signals of STATs that may have therapeutic potential for cancers caused by persistently activated STAT proteins. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOCHEMICAL PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/pharmacology* | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cytokines/metabolism | - |
dc.subject.MESH | Drug Screening Assays, Antitumor/methods | - |
dc.subject.MESH | Flavanones/pharmacology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Phosphorylation/drug effects | - |
dc.subject.MESH | STAT Transcription Factors/genetics | - |
dc.subject.MESH | STAT Transcription Factors/metabolism* | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Tyrosine/metabolism | - |
dc.title | Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Byung-Hak Kim | - |
dc.contributor.googleauthor | Cheolhee Won | - |
dc.contributor.googleauthor | Yun-Han Lee | - |
dc.contributor.googleauthor | Jung Sook Choi | - |
dc.contributor.googleauthor | Kum Hee Noh | - |
dc.contributor.googleauthor | Songhee Han | - |
dc.contributor.googleauthor | Haeri Lee | - |
dc.contributor.googleauthor | Chang Seok Lee | - |
dc.contributor.googleauthor | Dong-Sup Lee | - |
dc.contributor.googleauthor | Sang-Kyu Ye | - |
dc.contributor.googleauthor | Myoung-Hwan Kim | - |
dc.identifier.doi | 10.1016/j.bcp.2013.08.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03029 | - |
dc.relation.journalcode | J00283 | - |
dc.identifier.eissn | 1873-2968 | - |
dc.identifier.pmid | 23962443 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006295213004954 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Cancer | - |
dc.subject.keyword | STATs | - |
dc.subject.keyword | Small-molecule inhibitor | - |
dc.subject.keyword | Sophoraflavanone G | - |
dc.contributor.alternativeName | Lee, Yun Han | - |
dc.contributor.affiliatedAuthor | Lee, Yun Han | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 86 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 950 | - |
dc.citation.endPage | 959 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, Vol.86(7) : 950-959, 2013 | - |
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