Cited 6 times in
Inhibition of vacuolar H plus ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | 이윤한 | - |
dc.date.accessioned | 2014-12-18T09:26:29Z | - |
dc.date.available | 2014-12-18T09:26:29Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88176 | - |
dc.description.abstract | Resistance of estrogen receptor-positive breast cancer cells to tamoxifen represents a major barrier to the successful treatment of breast cancer. In the present study, we found that vacuolar H+ ATPase (vATPase) inhibitors, bafilomycin A1 and concanamycin A, sensitize tamoxifen-induced cell death. siRNA targeting ATP6V0C, a 16-kDa hydrophobic proteolipid subunit of vATPase that plays a central role in H+ transport, markedly increased cell death induced by tamoxifen. Interestingly, bafilomycin A1 induced up-regulation of DR4/DR5 and CHOP. Knock-down of CHOP by siRNA suppressed the cell death induced by bafilomycin A1 and tamoxifen, suggesting that bafilomycin A1-mediated CHOP activation sensitizes to tamoxifen. In addition, we found that bafilomycin A1 enhances TRAIL-induced cell death in breast cancer cells. Furthermore, we showed that combination of vATPase inhibitors with tamoxifen also effectively induced cell death in HER2- and ERα-overexpressing breast cancer cells. Overall, our results demonstrate that inhibition of vATPase can potentiate the apoptotic effects of tamoxifen through up-regulation of CHOP. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Apoptosis/physiology | - |
dc.subject.MESH | Breast Neoplasms/drug therapy* | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Cell Death/physiology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Drug Synergism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MCF-7 Cells | - |
dc.subject.MESH | Tamoxifen/pharmacology* | - |
dc.subject.MESH | Tamoxifen/toxicity | - |
dc.subject.MESH | Transcription Factor CHOP/antagonists & inhibitors | - |
dc.subject.MESH | Transcription Factor CHOP/biosynthesis* | - |
dc.subject.MESH | Transcription Factor CHOP/genetics | - |
dc.subject.MESH | Up-Regulation/drug effects* | - |
dc.subject.MESH | Up-Regulation/physiology | - |
dc.subject.MESH | Vacuolar Proton-Translocating ATPases/antagonists & inhibitors* | - |
dc.title | Inhibition of vacuolar H plus ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Hyeon-Ok Jin | - |
dc.contributor.googleauthor | Yun-Han Lee | - |
dc.contributor.googleauthor | Hyun-Ah Kim | - |
dc.contributor.googleauthor | Eun-Kyu Kim | - |
dc.contributor.googleauthor | Woo Chul Noh | - |
dc.contributor.googleauthor | Young-Sun Kim | - |
dc.contributor.googleauthor | Chang-Sun Hwang | - |
dc.contributor.googleauthor | Jong-Il Kim | - |
dc.contributor.googleauthor | Yoon Hwan Chang | - |
dc.contributor.googleauthor | Seok-Il Hong | - |
dc.contributor.googleauthor | Young-Jun Hong | - |
dc.contributor.googleauthor | In-Chul Park | - |
dc.contributor.googleauthor | Jin Kyung Lee | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.06.106 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03029 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 23838288 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X13011169 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | CHOP | - |
dc.subject.keyword | Estrogen receptor | - |
dc.subject.keyword | HER2 | - |
dc.subject.keyword | Tamoxifen | - |
dc.subject.keyword | Vacuolar H+ ATPase | - |
dc.contributor.alternativeName | Lee, Yun Han | - |
dc.contributor.affiliatedAuthor | Lee, Yun Han | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 437 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 463 | - |
dc.citation.endPage | 468 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.437(3) : 463-468, 2013 | - |
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