Cited 13 times in
Pathologic Correlation of Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment in Resected Nonsmall Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | 김대준 | - |
dc.contributor.author | 이석기 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 이창영 | - |
dc.contributor.author | 정경영 | - |
dc.date.accessioned | 2014-12-18T09:25:30Z | - |
dc.date.available | 2014-12-18T09:25:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2233-601X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88145 | - |
dc.description.abstract | BACKGROUND: This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: The records of 527 patients who underwent pulmonary resection of NSCLC were reviewed. The association between preoperative serum CEA and Cyfra 21-1 levels and variables that had p-values of less than 0.05 in a t-test or one-way analyses of variance was analyzed by multiple linear regression. RESULTS: The mean serum CEA and Cyfra 21-1 levels prior to surgery were 6.8±23.1 mg/dL (range, 0.01 to 390.8 mg/dL) and 5.4±12.3 mg/dL (range, 0.65 to 140.2 mg/dL). The serum CEA levels were associated with tumor (T) and lymph node (N) stage and histology. The serum Cyfra 21-1 levels were associated with T stage, tumor size, and histology. Multiple linear regression indicated that serum CEA levels were associated with T (T3/4 vs. T1: β=8.463, p=0.010) and N stage (N2/3 vs. N0: β=9.208, p<0.001) and histology (adenocarcinoma vs. squamous cell: β=6.838, p=0.001), and serum Cyfra 21-1 levels were associated with tumor size (β=2.579, p<0.001) and histology (squamous cell vs. adenocarcinoma: β=4.420, p=0.020). CONCLUSION: Serum CEA level was correlated with T and N stage, and Cyfra 21-1 with tumor size. CEA and Cyfra 21-1 showed histologic correlation. CEA is mainly elevated in adenocarcinoma and Cyfra 21-1 in squamous cell carcinoma. These results might be helpful for predicting pathologic status in preoperative NSCLC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Thoracic and Cardiovascular Surgery | - |
dc.relation.isPartOf | Korean Journal of Thoracic and Cardiovascular Surgery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Pathologic Correlation of Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment in Resected Nonsmall Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Seokkee Lee | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Dae Jin Hong | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.identifier.doi | 10.5090/kjtcs.2013.46.3.192 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A02851 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03245 | - |
dc.contributor.localId | A03571 | - |
dc.relation.journalcode | J02126 | - |
dc.identifier.eissn | 2093-6516 | - |
dc.identifier.pmid | 23772406 | - |
dc.subject.keyword | Carcinoembryonic antigen (CEA) | - |
dc.subject.keyword | Carcinoma, non-small cell, lung | - |
dc.subject.keyword | Cytokeratin 19 fragment (Cyfra 21-1) | - |
dc.subject.keyword | Neoplasm biology | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Lee, Seok Kee | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Lee, Seok Kee | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Chung, Kyung Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 192 | - |
dc.citation.endPage | 195 | - |
dc.identifier.bibliographicCitation | Korean Journal of Thoracic and Cardiovascular Surgery, Vol.46(3) : 192-195, 2013 | - |
dc.identifier.rimsid | 33085 | - |
dc.type.rims | ART | - |
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