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Pathologic Correlation of Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment in Resected Nonsmall Cell Lung Cancer

DC Field Value Language
dc.contributor.author김대준-
dc.contributor.author이석기-
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.contributor.author정경영-
dc.date.accessioned2014-12-18T09:25:30Z-
dc.date.available2014-12-18T09:25:30Z-
dc.date.issued2013-
dc.identifier.issn2233-601X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88145-
dc.description.abstractBACKGROUND: This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: The records of 527 patients who underwent pulmonary resection of NSCLC were reviewed. The association between preoperative serum CEA and Cyfra 21-1 levels and variables that had p-values of less than 0.05 in a t-test or one-way analyses of variance was analyzed by multiple linear regression. RESULTS: The mean serum CEA and Cyfra 21-1 levels prior to surgery were 6.8±23.1 mg/dL (range, 0.01 to 390.8 mg/dL) and 5.4±12.3 mg/dL (range, 0.65 to 140.2 mg/dL). The serum CEA levels were associated with tumor (T) and lymph node (N) stage and histology. The serum Cyfra 21-1 levels were associated with T stage, tumor size, and histology. Multiple linear regression indicated that serum CEA levels were associated with T (T3/4 vs. T1: β=8.463, p=0.010) and N stage (N2/3 vs. N0: β=9.208, p<0.001) and histology (adenocarcinoma vs. squamous cell: β=6.838, p=0.001), and serum Cyfra 21-1 levels were associated with tumor size (β=2.579, p<0.001) and histology (squamous cell vs. adenocarcinoma: β=4.420, p=0.020). CONCLUSION: Serum CEA level was correlated with T and N stage, and Cyfra 21-1 with tumor size. CEA and Cyfra 21-1 showed histologic correlation. CEA is mainly elevated in adenocarcinoma and Cyfra 21-1 in squamous cell carcinoma. These results might be helpful for predicting pathologic status in preoperative NSCLC.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Thoracic and Cardiovascular Surgery-
dc.relation.isPartOfKorean Journal of Thoracic and Cardiovascular Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePathologic Correlation of Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment in Resected Nonsmall Cell Lung Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorSeokkee Lee-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorDae Jin Hong-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorKyung Young Chung-
dc.identifier.doi10.5090/kjtcs.2013.46.3.192-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00368-
dc.contributor.localIdA02851-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.contributor.localIdA03571-
dc.relation.journalcodeJ02126-
dc.identifier.eissn2093-6516-
dc.identifier.pmid23772406-
dc.subject.keywordCarcinoembryonic antigen (CEA)-
dc.subject.keywordCarcinoma, non-small cell, lung-
dc.subject.keywordCytokeratin 19 fragment (Cyfra 21-1)-
dc.subject.keywordNeoplasm biology-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNameLee, Seok Kee-
dc.contributor.alternativeNameLee, Jin Gu-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorLee, Seok Kee-
dc.contributor.affiliatedAuthorLee, Jin Gu-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.contributor.affiliatedAuthorChung, Kyung Young-
dc.rights.accessRightsfree-
dc.citation.volume46-
dc.citation.number3-
dc.citation.startPage192-
dc.citation.endPage195-
dc.identifier.bibliographicCitationKorean Journal of Thoracic and Cardiovascular Surgery, Vol.46(3) : 192-195, 2013-
dc.identifier.rimsid33085-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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