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Parenteral Nutrition Associated Cholestasis Is Earlier, More Prolonged and Severe in Small for Gestational Age Compared with Appropriate for Gestational Age Very Low Birth Weight Infants

DC FieldValueLanguage
dc.contributor.author김남효-
dc.contributor.author남궁란-
dc.contributor.author박국인-
dc.contributor.author박민수-
dc.contributor.author은호선-
dc.contributor.author이순민-
dc.contributor.author이철-
dc.date.accessioned2014-12-18T09:23:36Z-
dc.date.available2014-12-18T09:23:36Z-
dc.date.issued2013-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88086-
dc.description.abstractPURPOSE: We hypothesized that parenteral nutrition associated cholestasis (PNAC) would be more severe in small for gestational age (SGA) compared with appropriate for gestational age (AGA) very low birth weight (VLBW) infants. MATERIALS AND METHODS: Sixty-one VLBW infants were diagnosed as PNAC with exposure to parenteral nutrition with elevation of direct bilirubin≥2 mg/dL for ≥14 days. Twenty-one SGA infants and 40 AGA infants matched for gestation were compared. RESULTS: Compared with AGA infants, PNAC in SGA infants was diagnosed earlier (25±7 days vs. 35±14 days, p=0.002) and persisted longer (62±36 days vs. 46±27 days, p=0.048). Severe PNAC, defined as persistent elevation of direct bilirubin≥4 mg/dL for more than 1 month with elevation of liver enzymes, was more frequent in SGA than in AGA infants (61% vs. 35%, p=0.018). The serum total bilirubin and direct bilirubin levels during the 13 weeks of life were significantly different in SGA compared with AGA infants. SGA infants had more frequent (76% vs. 50%, p=0.046), and persistent elevation of alanine aminotransferase. CONCLUSION: The clinical course of PNAC is more persistent and severe in SGA infants. Careful monitoring and treatment are required for SGA infants.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBilirubin/blood-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCholestasis/diagnosis-
dc.subject.MESHCholestasis/epidemiology-
dc.subject.MESHCholestasis/etiology*-
dc.subject.MESHComorbidity-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHInfant, Premature, Diseases/epidemiology-
dc.subject.MESHInfant, Premature, Diseases/etiology-
dc.subject.MESHInfant, Small for Gestational Age*-
dc.subject.MESHInfant, Very Low Birth Weight-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHLiver/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHParenteral Nutrition/adverse effects*-
dc.titleParenteral Nutrition Associated Cholestasis Is Earlier, More Prolonged and Severe in Small for Gestational Age Compared with Appropriate for Gestational Age Very Low Birth Weight Infants-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorSoon Min Lee-
dc.contributor.googleauthorRan Namgung-
dc.contributor.googleauthorMin Soo Park-
dc.contributor.googleauthorHo Sun Eun-
dc.contributor.googleauthorNam Hyo Kim-
dc.contributor.googleauthorKook In Park-
dc.contributor.googleauthorChul Lee-
dc.identifier.doi10.3349/ymj.2013.54.4.839-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00359-
dc.contributor.localIdA01241-
dc.contributor.localIdA01438-
dc.contributor.localIdA01468-
dc.contributor.localIdA02635-
dc.contributor.localIdA02905-
dc.contributor.localIdA03253-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23709416-
dc.subject.keywordParenteral nutrition associated cholestasis-
dc.subject.keywordappropriate for gestational age-
dc.subject.keywordhepatic dysfunction-
dc.subject.keywordsmall for gestational age-
dc.contributor.alternativeNameKim, Nam Hyo-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameEun, Ho Seon-
dc.contributor.alternativeNameLee, Soon Min-
dc.contributor.alternativeNameLee, Chul-
dc.contributor.affiliatedAuthorKim, Nam Hyo-
dc.contributor.affiliatedAuthorNamgung, Ran-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.contributor.affiliatedAuthorEun, Ho Seon-
dc.contributor.affiliatedAuthorLee, Soon Min-
dc.contributor.affiliatedAuthorLee, Chul-
dc.rights.accessRightsfree-
dc.citation.volume54-
dc.citation.number4-
dc.citation.startPage839-
dc.citation.endPage844-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.54(4) : 839-844, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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