169 339

Cited 15 times in

Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study

DC Field Value Language
dc.contributor.author김지현-
dc.contributor.author박효진-
dc.contributor.author윤영훈-
dc.contributor.author임현철-
dc.date.accessioned2014-12-18T09:23:23Z-
dc.date.available2014-12-18T09:23:23Z-
dc.date.issued2013-
dc.identifier.issn2093-0879-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88079-
dc.description.abstractBackground/Aims Proton pump inhibitors (PPIs) which are the most effective agents for the treatment of gastroesophageal reflux disease (GERD), have been known to delay gastric emptying. Mosapride has been used as prokinetics by accelerating gastric emptying. We evaluated the efficacy of mosapride to prevent PPI-induced delayed gastric emptying in a prospective randomized, double-blind and placebo-controlled trial. Methods Thirty patients who were diagnosed as GERD and had normal gastric emptying were included in this study. PPI monotherapy group was treated with placebo drug in addition to pantoprazole and PPI plus mosapride group was treated with mosapride in addition to pantoprazole for 8 weeks. Gastric emptying scan and questionnaires about GERD and dyspeptic symptoms were assessed by scoring before and after treatment. To evaluate the changes of gastrointestinal endocrine hormones by PPI which are associated gastric acid secretion and gastric motility, fasting plasma gastrin and cholecystokinin were taken at weeks 0 and 8. Results Half gastric emptying time was increased ( = 0.023) in PPI monotherapy group, and there were no significant changes in PPI plus mosapride group. Plasma gastrin level increased in PPI monotherpay group ( = 0.028) and there were no significant changes in PPI plus mosapride group. Plasma cholecystokinin level was not changed after treatment in both groups. GERD symptoms were improved after treatment in both groups, and postprandial bloating and nausea were improved in PPI plus mosapride group. Conclusions Mosapride showed to be effective in preventing delayed gastric emptying and the increase in plasma gastrin level induced by PPI treatment, but did not show prominent clinical symptom improvements.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyun Chul Lim-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorEun Hee Lee-
dc.contributor.googleauthorByung Keon Lee-
dc.contributor.googleauthorHyojin Park-
dc.identifier.doi10.5056/jnm.2013.19.4.495-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01774-
dc.contributor.localIdA02583-
dc.contributor.localIdA03418-
dc.contributor.localIdA00996-
dc.relation.journalcodeJ01623-
dc.identifier.eissn2093-0887-
dc.identifier.pmid24199010-
dc.subject.keywordGastric emptying-
dc.subject.keywordGastroesophageal reflux-
dc.subject.keywordMosapride-
dc.subject.keywordProton pump inhibitors-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameYoun, Young Hoon-
dc.contributor.alternativeNameLim, Hyun Chul-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorYoun, Young Hoon-
dc.contributor.affiliatedAuthorLim, Hyun Chul-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.rights.accessRightsfree-
dc.citation.volume19-
dc.citation.number4-
dc.citation.startPage495-
dc.citation.endPage502-
dc.identifier.bibliographicCitationJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.19(4) : 495-502, 2013-
dc.identifier.rimsid32749-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.