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Early volumetric change and treatment outcome of metastatic brain tumors after external beam radiotherapy: differential radiotherapy for brain metastasis.

DC FieldValueLanguage
dc.contributor.author서창옥-
dc.contributor.author이동수-
dc.contributor.author이창걸-
dc.contributor.author조재호-
dc.date.accessioned2014-12-18T09:23:08Z-
dc.date.available2014-12-18T09:23:08Z-
dc.date.issued2013-
dc.identifier.issn1699-048X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88072-
dc.description.abstractPURPOSE: To evaluate the treatment outcomes of low-dose whole brain radiation therapy (WBRT)-based differential radiation therapy (RT) for metastatic brain tumors. METHODS: A total of 242 targets (metastatic brain lesions) were analyzed in the present study. Median WBRT dose and number of fractions were 25 (range 25-35) Gy and 10 (range 8-15) fractions, respectively. A median normalized total dose (NTD) of 1.8 Gy (NTD(1.8Gy)) to the metastatic lesion was 45 (range 27-64.8) Gy. We numbered and contoured each metastatic lesion sequentially using computed tomography fused with serial magnetic resonance imaging to evaluate volumetric changes. RESULTS: The 6-month and 1-year freedom from remote intracranial failure rates were 87.7 and 58.5 %, respectively. The 6-month actuarial local control (LC) rate was 93.4 %. Tumor diameter was a major determinant for LC, and tumor histology was a significant parameter predicting the volume reduction rate. With overall complete response (CR) rate of 56.6 % after RT, CR rate, if the target was more than 1 cm in size, was 25 % with a median NTD(1.8Gy) of 45 Gy, requiring dose escalation to achieve better target regression. CONCLUSIONS: Low-dose WBRT with selective boost was feasible and effective. Our results pose the rationale of future trial of differential radiation therapy (RT), which prescribes different radiation dose according to the tumor density in metastatic brain tumors.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICAL & TRANSLATIONAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBrain Neoplasms/mortality-
dc.subject.MESHBrain Neoplasms/radiotherapy*-
dc.subject.MESHBrain Neoplasms/secondary*-
dc.subject.MESHCranial Irradiation*-
dc.subject.MESHDose Fractionation*-
dc.subject.MESHFeasibility Studies-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeoplasms/mortality-
dc.subject.MESHNeoplasms/pathology-
dc.subject.MESHNeoplasms/radiotherapy*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleEarly volumetric change and treatment outcome of metastatic brain tumors after external beam radiotherapy: differential radiotherapy for brain metastasis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorD. S. Lee-
dc.contributor.googleauthorY. S. Kim-
dc.contributor.googleauthorC. G. Lee-
dc.contributor.googleauthorJ. H. Lim-
dc.contributor.googleauthorC.-O. Suh-
dc.contributor.googleauthorH. J. Kim-
dc.contributor.googleauthorJ. Cho-
dc.identifier.doi10.1007/s12094-013-1016-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03901-
dc.contributor.localIdA01919-
dc.contributor.localIdA02724-
dc.contributor.localIdA03240-
dc.relation.journalcodeJ00558-
dc.identifier.eissn1699-3055-
dc.identifier.pmid23408041-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs12094-013-1016-2-
dc.subject.keywordBoost-
dc.subject.keywordBrain Metastases-
dc.subject.keywordRadiotherapy-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameLee, Dong Soo-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorLee, Dong Soo-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.rights.accessRightsnot free-
dc.citation.volume15-
dc.citation.number11-
dc.citation.startPage889-
dc.citation.endPage896-
dc.identifier.bibliographicCitationCLINICAL & TRANSLATIONAL ONCOLOGY, Vol.15(11) : 889-896, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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