Cited 14 times in
Effect of lanthanum carbonate on phosphate control in continuous ambulatory peritoneal dialysis patients in Korea: a randomized prospective study
DC Field | Value | Language |
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dc.contributor.author | 이호영 | - |
dc.contributor.author | 최훈영 | - |
dc.date.accessioned | 2014-12-18T09:21:48Z | - |
dc.date.available | 2014-12-18T09:21:48Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0301-0430 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88031 | - |
dc.description.abstract | BACKGROUND: Hyperphosphatemia is a common complication in end-stage renal disease (ESRD) patients. Reducing the serum phosphate level is crucial in management of ESRD. METHODS: This study was a randomized prospective study, designed to compare patients with hyperphosphatemia undergoing peritoneal dialysis while taking lanthanum carbonate or calcium carbonate. We divided 72 continuous ambulatory peritoneal dialysis (CAPD) patients whose serum phosphate levels were over 5.6 mg/dl into two groups to receive either lanthanum carbonate or calcium carbonate. Serum calcium, phosphate and PTH levels were examined serially for 24 weeks. RESULTS: Both lanthanum carbonate and calcium carbonate reduced serum phosphate levels, from 6.79 ± 1.05 to 5.44 ± 1.44 and from 6.31 ± 1.13 to 4.74 ± 0.78 mg/dl, respectively. The calcium × phosphate product level was reduced in the lanthanum carbonate and calcium carbonate groups from 60.23 ± 10.23 to 46.97 ± 16.42 and from 57.92 ± 11.05 to 44.50 ± 7.74 mg2/dl2, respectively. The serum parathyroid hormone (PTH) level in the lanthanum carbonate group did not change significantly compared to baseline during the study, but in the calcium carbonate group, the serum PTH level decreased significantly. Gastrointestinal complications were the main adverse effects of lanthanum carbonate and 11 out of 35 patients dropped out of the study due to this complication. CONCLUSIONS: Lanthanum carbonate was as effective as calcium carbonate in reducing serum phosphate level, and serum PTH level tended to be steadier in the lanthanum carbonate group compared to the calcium carbonate group. Though the ifference was not significant, lanthanum carbonate tended not to elevate serum calcium level in CAPD patients compared to calcium carbonate. The high incidence of gastrointestinal adverse effect in the lanthanum carbonate group will need further evaluation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Calcium/blood | - |
dc.subject.MESH | Calcium Carbonate/administration & dosage | - |
dc.subject.MESH | Calcium Carbonate/therapeutic use | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperphosphatemia/blood | - |
dc.subject.MESH | Hyperphosphatemia/drug therapy* | - |
dc.subject.MESH | Hyperphosphatemia/prevention & control | - |
dc.subject.MESH | Kidney Failure, Chronic/blood* | - |
dc.subject.MESH | Kidney Failure, Chronic/therapy* | - |
dc.subject.MESH | Lanthanum/adverse effects | - |
dc.subject.MESH | Lanthanum/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Parathyroid Hormone/blood | - |
dc.subject.MESH | Peritoneal Dialysis, Continuous Ambulatory/methods* | - |
dc.subject.MESH | Phosphates/blood* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Effect of lanthanum carbonate on phosphate control in continuous ambulatory peritoneal dialysis patients in Korea: a randomized prospective study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yong Kyu Lee | - |
dc.contributor.googleauthor | Hoon Young Choi | - |
dc.contributor.googleauthor | Sug Kyun Shin | - |
dc.contributor.googleauthor | Ho Yung Lee | - |
dc.identifier.doi | 10.5414/CN107362 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02110 | - |
dc.contributor.localId | A02975 | - |
dc.contributor.localId | A03326 | - |
dc.contributor.localId | A04226 | - |
dc.relation.journalcode | J00588 | - |
dc.identifier.pmid | 23211335 | - |
dc.identifier.url | http://www.dustri.com/nc/article-response-page.html?artId=10189&doi= | - |
dc.subject.keyword | continuous ambulatory peritoneal dialysis | - |
dc.subject.keyword | end-stage renal disease | - |
dc.subject.keyword | hyperphosphatemia | - |
dc.subject.keyword | lanthanum carbonate | - |
dc.subject.keyword | renal osteodystrophy | - |
dc.contributor.alternativeName | Shin, Sug Kyun | - |
dc.contributor.alternativeName | Lee, Yong Kyu | - |
dc.contributor.alternativeName | Lee, Ho Yung | - |
dc.contributor.alternativeName | Choi, Hoon Young | - |
dc.contributor.affiliatedAuthor | Shin, Sug Kyun | - |
dc.contributor.affiliatedAuthor | Lee, Yong Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Ho Yung | - |
dc.contributor.affiliatedAuthor | Choi, Hoon Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 79 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 136 | - |
dc.citation.endPage | 142 | - |
dc.identifier.bibliographicCitation | CLINICAL NEPHROLOGY, Vol.79(2) : 136-142, 2013 | - |
dc.identifier.rimsid | 32714 | - |
dc.type.rims | ART | - |
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