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Prognostic Value of Mucinous Histology Depends on Microsatellite Instability Status in Patients with Stage III Colon Cancer Treated with Adjuvant FOLFOX Chemotherapy: A Retrospective Cohort Study

DC FieldValueLanguage
dc.contributor.author김세현-
dc.contributor.author김태일-
dc.contributor.author김현기-
dc.contributor.author노재경-
dc.contributor.author민병소-
dc.contributor.author신상준-
dc.contributor.author안중배-
dc.contributor.author이강영-
dc.contributor.author정현철-
dc.contributor.author허혁-
dc.contributor.author강대용-
dc.contributor.author김남규-
dc.date.accessioned2014-12-18T09:21:37Z-
dc.date.available2014-12-18T09:21:37Z-
dc.date.issued2013-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88025-
dc.description.abstractBACKGROUND: The close association between mucinous histology and microsatellite instability (MSI) may have hindered the evaluation of prognostic significance of mucinous histology. The aim of this retrospective study was to investigate whether mucinous histology was associated with a worse prognosis, independent of MSI status, compared to nonmucinous histology in patients with stage III colon cancer. METHODS: This study enrolled 394 consecutive patients with stage III colorectal cancer treated with adjuvant FOLFOX after curative resection (R0). Clinicopathological information was retrospectively reviewed. Tumors were analyzed for MSI by polymerase chain reaction to determine MSI status. Kaplan-Meier method, log-rank test, and Cox proportional hazard regression models were used. RESULTS: The estimated rate of 3-year disease-free survival (DFS) in patients with nonmucinous adenocarcinoma (NMA 79.2 %) was significantly greater than that in patients with mucinous adenocarcinoma (MA) and adenocarcinoma with mucinous component (MC) (56.9 %; log-rank, P = 0.002). In univariate analysis, histology (NMA vs. MA/MC), American Joint Committee on Cancer stage (IIIA, IIIB, and IIIC), and lymphovascular invasion (present vs. absent) were significantly associated with DFS. In multivariate analysis, mucinous histology (MA/MC) was associated with decreased DFS in all patients (hazard ratio 1.82, 95 % confidence interval 1.03-3.23, P = 0.0403). In patients with MA/MC, no difference in DFS was observed between MSI and microsatellite stability (log-rank, P = 0.732). CONCLUSIONS: Mucinous histology is an independent poor prognostic factor for DFS in patients with stage III colon cancer after adjuvant FOLFOX chemotherapy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAnnals of Surgical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrognostic Value of Mucinous Histology Depends on Microsatellite Instability Status in Patients with Stage III Colon Cancer Treated with Adjuvant FOLFOX Chemotherapy: A Retrospective Cohort Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorSe Hyun Kim-
dc.contributor.googleauthorSang Joon Shin-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorDae Ryong Kang-
dc.contributor.googleauthorHyuk Hur-
dc.contributor.googleauthorByung So Min-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorHyun Chul Chung-
dc.contributor.googleauthorJae Kyung Roh-
dc.contributor.googleauthorJoong Bae Ahn-
dc.identifier.doi10.1245/s10434-013-3169-1-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00607-
dc.contributor.localIdA01079-
dc.contributor.localIdA01108-
dc.contributor.localIdA01290-
dc.contributor.localIdA01402-
dc.contributor.localIdA02105-
dc.contributor.localIdA02262-
dc.contributor.localIdA02640-
dc.contributor.localIdA03773-
dc.contributor.localIdA04373-
dc.contributor.localIdA00353-
dc.contributor.localIdA00009-
dc.relation.journalcodeJ00179-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-013-3169-1-
dc.contributor.alternativeNameKim, Se Hyun-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameMin, Byung Soh-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameHur, Hyuk-
dc.contributor.alternativeNameKang, Dae Ryong-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.affiliatedAuthorKim, Se Hyun-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorMin, Byung Soh-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorHur, Hyuk-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorKang, Dae Ryong-
dc.rights.accessRightsnot free-
dc.citation.volume20-
dc.citation.number11-
dc.citation.startPage3407-
dc.citation.endPage3413-
dc.identifier.bibliographicCitationAnnals of Surgical Oncology, Vol.20(11) : 3407-3413, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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