2 558

Cited 25 times in

A prospective, randomized, double-blind, multicenter comparative study on the safety and efficacy of Celecoxib and GCSB-5, dried extracts of six herbs, for the treatment of osteoarthritis of knee joint

DC Field Value Language
dc.contributor.author한창동-
dc.date.accessioned2014-12-18T09:19:09Z-
dc.date.available2014-12-18T09:19:09Z-
dc.date.issued2013-
dc.identifier.issn0378-8741-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87948-
dc.description.abstractETHNOPHARMACOLOGICAL RELEVANCE: This prospective, randomized, double-blind, multicenter study compared the efficacy and safety of Celecoxib and GCSB-5, a new product from extracts of six herbs, for the treatment of knee osteoarthritis. MATERIALS AND METHODS: A total of 198 eligible patients were randomly assigned to the Celecoxib group (n=99 patients) or the GCSB-5 group (n=99 patients) for the 12-week study. The amount of change and percentage of the change in Western Ontario and McMaster Universities (WOMAC) Arthritis Index from the baseline, the change in pain on walking by visual analogue scale (VAS), physician's global assessment on response to therapy (PGART) by five point Likert scale, and the amount of rescue medicine taken were used as parameters for efficacy. Adverse drug reactions (ADRs) were carefully investigated. RESULTS: The WOMAC score improved in both the Celecoxib group and GCSB-5 group by 20.5 and 21.3 (P=0.79). The percentage of the change in WOMAC score were -42.0% and -38.9% (P=0.54). The pain VAS score decreased by 29.9 and 27.9 (P=0.58). The responders by PGART were 95.3% and 93.8% (P= 0.66), and the median amount of rescue medicine taken were 2.0 and 6.5 tablets (P=0.06). The incidence of ADRs were 31.3% and 21.2% (P=0.11). The most common ADRs were gastrointestinal system related; 17.2% in GCSB-5 group and 22.2% in Celecoxib group. Any severe ADR was not observed in either group. CONCLUSIONS: The result of this study supports that GCSB-5 is comparable to Celecoxib in terms of the efficacy and safety for the treatment of osteoarthritis of knee joint.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF ETHNOPHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCelecoxib-
dc.subject.MESHCyclooxygenase 2 Inhibitors/administration & dosage-
dc.subject.MESHCyclooxygenase 2 Inhibitors/adverse effects-
dc.subject.MESHCyclooxygenase 2 Inhibitors/therapeutic use*-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsteoarthritis, Knee/drug therapy*-
dc.subject.MESHPain Measurement-
dc.subject.MESHPlant Extracts/administration & dosage-
dc.subject.MESHPlant Extracts/adverse effects-
dc.subject.MESHPlant Extracts/therapeutic use*-
dc.subject.MESHProspective Studies-
dc.subject.MESHPyrazoles/administration & dosage-
dc.subject.MESHPyrazoles/adverse effects-
dc.subject.MESHPyrazoles/therapeutic use*-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSulfonamides/administration & dosage-
dc.subject.MESHSulfonamides/adverse effects-
dc.subject.MESHSulfonamides/therapeutic use*-
dc.subject.MESHSurveys and Questionnaires-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHWalking-
dc.titleA prospective, randomized, double-blind, multicenter comparative study on the safety and efficacy of Celecoxib and GCSB-5, dried extracts of six herbs, for the treatment of osteoarthritis of knee joint-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthorYong-Geun Park-
dc.contributor.googleauthorChul-Won Ha-
dc.contributor.googleauthorChang-Dong Han-
dc.contributor.googleauthorSeong-Il Bin-
dc.contributor.googleauthorHee-Chun Kim-
dc.contributor.googleauthorYoung-Bok Jung-
dc.contributor.googleauthorHong-Chul Lim-
dc.identifier.doi10.1016/j.jep.2013.08.008-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04330-
dc.relation.journalcodeJ01406-
dc.identifier.eissn1872-7573-
dc.identifier.pmid23954277-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0378874113005503-
dc.subject.keywordADR-
dc.subject.keywordAE-
dc.subject.keywordCOX-1-
dc.subject.keywordCOX-2 inhibitor-
dc.subject.keywordCelecoxib-
dc.subject.keywordEfficacy-
dc.subject.keywordFDA-
dc.subject.keywordFood and Drug Administration-
dc.subject.keywordGCSB-5-
dc.subject.keywordGEE-
dc.subject.keywordIL-1beta-
dc.subject.keywordITT-
dc.subject.keywordK/L-
dc.subject.keywordKellgren and Lawrence-
dc.subject.keywordKnee-
dc.subject.keywordLOCF-
dc.subject.keywordMCID-
dc.subject.keywordNSAIDs-
dc.subject.keywordOA-
dc.subject.keywordOsteoarthritis-
dc.subject.keywordPGART-
dc.subject.keywordPGI2-
dc.subject.keywordPP-
dc.subject.keywordSD-
dc.subject.keywordTNF-α-
dc.subject.keywordTXA2-
dc.subject.keywordVAS-
dc.subject.keywordWOMAC-
dc.subject.keywordWestern Ontario and McMaster Universities Arthritis Index-
dc.subject.keywordadverse drug reaction-
dc.subject.keywordadverse events-
dc.subject.keywordcyclooxygenase-1-
dc.subject.keywordcyclooxygenase-2 inhibitor-
dc.subject.keywordgeneralized estimating equation-
dc.subject.keywordinteleukin-1β-
dc.subject.keywordintention to Treat-
dc.subject.keywordlast observation carried forward-
dc.subject.keywordminimum clinically important differences-
dc.subject.keywordnon-steroidal anti-inflammatory drugs-
dc.subject.keywordosteoarthritis-
dc.subject.keywordper protocol-
dc.subject.keywordprostaglandin I2-
dc.subject.keywordstandard deviation-
dc.subject.keywordthe physician's global assessment of response to therapy-
dc.subject.keywordthromboxane A2-
dc.subject.keywordtissue necrotic factor alpha-
dc.subject.keywordvisual analogue scale-
dc.contributor.alternativeNameHan, Chang Dong-
dc.contributor.affiliatedAuthorHan, Chang Dong-
dc.rights.accessRightsnot free-
dc.citation.volume149-
dc.citation.number3-
dc.citation.startPage816-
dc.citation.endPage824-
dc.identifier.bibliographicCitationJOURNAL OF ETHNOPHARMACOLOGY, Vol.149(3) : 816-824, 2013-
dc.identifier.rimsid33867-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.