Cited 29 times in
The benefit of adjuvant chemotherapy combined with postoperative radiotherapy for endometrial cancer: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김용배 | - |
dc.contributor.author | 남은지 | - |
dc.contributor.author | 박현종 | - |
dc.date.accessioned | 2014-12-18T09:19:07Z | - |
dc.date.available | 2014-12-18T09:19:07Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0301-2115 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87947 | - |
dc.description.abstract | The objective of our study was to determine whetheradjuvant chemotherapycombinedwithpostoperativeradiotherapywould have benefits for the disease-free survival and overall survival in patients with high-riskendometrial cancer. Electronic searches for studies ofadjuvant chemotherapycombinedwithpostoperativeradiotherapyinendometrial cancerpatients between March 1971 and March 2012 were made on MEDLINE, SCOPUS, and the Cochrane library. Articles with more than 4 stars on the Newcastle-Ottawa scale or a score of more than 4 on the modified Jadad scale were included. Ameta-analysiswas performed, and pooled hazard ratios (HR) of progression-free survival (PFS) and overall survival (OS) between patients whoseadjuvant chemotherapywascombinedwithradiotherapy(the CTx+RTx group) and patients withadjuvantradiotherapyonly (the RTx group) were derived from the fixed effect model or random effect model. Three observational studies and 3 randomized clinical trials (RCTs) were included in the final analysis. Subgroup analysis for FIGO stage showed that the CTx+RTx group had a more significant survivalbenefitcompared to that of the RTx group in advanced stageendometrial cancer(OS HR 0.53, 95% CI 0.36-0.80; PFS HR 0.54, 95% CI 0.37-0.77), but no significantbenefitin early stageendometrial cancer(OS HR 0.96, 95% CI 0.70-1.32; PFS HR 1.00, 95% CI 0.39-2.58). Thismeta-analysissuggests thatadjuvant chemotherapycombinedwithpostoperativeradiotherapycould probably reduce disease progression and overall death in patients with advanced-stage disease. In order to examine whether the multimodal treatment hasbenefitin high-riskendometrial cancer, we need further large-scale RCTs. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use* | - |
dc.subject.MESH | Chemotherapy, Adjuvant* | - |
dc.subject.MESH | Endometrial Neoplasms/therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasm Recurrence, Local/prevention & control* | - |
dc.subject.MESH | Postoperative Period | - |
dc.subject.MESH | Radiotherapy, Adjuvant | - |
dc.title | The benefit of adjuvant chemotherapy combined with postoperative radiotherapy for endometrial cancer: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Hyun Jong Park | - |
dc.contributor.googleauthor | Eun Ji Nam | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.identifier.doi | 10.1016/j.ejogrb.2013.06.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A01746 | - |
dc.relation.journalcode | J00834 | - |
dc.identifier.eissn | 1872-7654 | - |
dc.identifier.pmid | 23810000 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0301211513002686 | - |
dc.subject.keyword | Chemotherapy | - |
dc.subject.keyword | Endometrial cancer | - |
dc.subject.keyword | Meta-analysis | - |
dc.subject.keyword | Radiotherapy | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.alternativeName | Nam, Eun Ji | - |
dc.contributor.alternativeName | Park, Hyun Jong | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Nam, Eun Ji | - |
dc.contributor.affiliatedAuthor | Park, Hyun Jong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 170 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 44 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol.170(1) : 39-44, 2013 | - |
dc.identifier.rimsid | 33866 | - |
dc.type.rims | ART | - |
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