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Cited 19 times in

The benefit of adjuvant chemotherapy combined with postoperative radiotherapy for endometrial cancer: a meta-analysis

DC FieldValueLanguage
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김용배-
dc.contributor.author남은지-
dc.contributor.author박현종-
dc.date.accessioned2014-12-18T09:19:07Z-
dc.date.available2014-12-18T09:19:07Z-
dc.date.issued2013-
dc.identifier.issn0301-2115-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87947-
dc.description.abstractThe objective of our study was to determine whetheradjuvant chemotherapycombinedwithpostoperativeradiotherapywould have benefits for the disease-free survival and overall survival in patients with high-riskendometrial cancer. Electronic searches for studies ofadjuvant chemotherapycombinedwithpostoperativeradiotherapyinendometrial cancerpatients between March 1971 and March 2012 were made on MEDLINE, SCOPUS, and the Cochrane library. Articles with more than 4 stars on the Newcastle-Ottawa scale or a score of more than 4 on the modified Jadad scale were included. Ameta-analysiswas performed, and pooled hazard ratios (HR) of progression-free survival (PFS) and overall survival (OS) between patients whoseadjuvant chemotherapywascombinedwithradiotherapy(the CTx+RTx group) and patients withadjuvantradiotherapyonly (the RTx group) were derived from the fixed effect model or random effect model. Three observational studies and 3 randomized clinical trials (RCTs) were included in the final analysis. Subgroup analysis for FIGO stage showed that the CTx+RTx group had a more significant survivalbenefitcompared to that of the RTx group in advanced stageendometrial cancer(OS HR 0.53, 95% CI 0.36-0.80; PFS HR 0.54, 95% CI 0.37-0.77), but no significantbenefitin early stageendometrial cancer(OS HR 0.96, 95% CI 0.70-1.32; PFS HR 1.00, 95% CI 0.39-2.58). Thismeta-analysissuggests thatadjuvant chemotherapycombinedwithpostoperativeradiotherapycould probably reduce disease progression and overall death in patients with advanced-stage disease. In order to examine whether the multimodal treatment hasbenefitin high-riskendometrial cancer, we need further large-scale RCTs.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntineoplastic Agents/therapeutic use*-
dc.subject.MESHChemotherapy, Adjuvant*-
dc.subject.MESHEndometrial Neoplasms/therapy*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHNeoplasm Recurrence, Local/prevention & control*-
dc.subject.MESHPostoperative Period-
dc.subject.MESHRadiotherapy, Adjuvant-
dc.titleThe benefit of adjuvant chemotherapy combined with postoperative radiotherapy for endometrial cancer: a meta-analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorHyun Jong Park-
dc.contributor.googleauthorEun Ji Nam-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorYoung Tae Kim-
dc.identifier.doi10.1016/j.ejogrb.2013.06.009-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00595-
dc.contributor.localIdA00744-
dc.contributor.localIdA00729-
dc.contributor.localIdA01262-
dc.contributor.localIdA01746-
dc.relation.journalcodeJ00834-
dc.identifier.eissn1872-7654-
dc.identifier.pmid23810000-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0301211513002686-
dc.subject.keywordChemotherapy-
dc.subject.keywordEndometrial cancer-
dc.subject.keywordMeta-analysis-
dc.subject.keywordRadiotherapy-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameNam, Eun Ji-
dc.contributor.alternativeNamePark, Hyun Jong-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorNam, Eun Ji-
dc.contributor.affiliatedAuthorPark, Hyun Jong-
dc.rights.accessRightsnot free-
dc.citation.volume170-
dc.citation.number1-
dc.citation.startPage39-
dc.citation.endPage44-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol.170(1) : 39-44, 2013-
dc.identifier.rimsid33866-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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