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Is Small Prostate Volume a Predictor of Gleason Score Upgrading after Radical Prostatectomy?

DC FieldValueLanguage
dc.contributor.author이동훈-
dc.contributor.author이승환-
dc.contributor.author정병하-
dc.date.accessioned2014-12-18T09:18:07Z-
dc.date.available2014-12-18T09:18:07Z-
dc.date.issued2013-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87915-
dc.description.abstractPURPOSE: We aimed to analyze the relationship between prostate volume and Gleason score (GS) upgrading [higher GS category in the radical prostatectomy (RP) specimen than in the prostate biopsy] in Korean men. MATERIALS AND METHODS: We retrospectively analyzed the medical records of 247 men who underwent RP between May 2006 and April 2011 at our institution. Transrectal ultrasound (TRUS) volume was categorized as 25 cm³ or less (n=61), 25 to 40 cm³ (n=121) and greater than 40 cm³ (n=65). GS was examined as a categorical variable of 6 or less, 3+4 and 4+3 or greater. The relationship between TRUS volume and upgrading of GS was analyzed using multivariate logistic regression. RESULTS: Overall, 87 patients (35.2%) were upgraded, 20 (8.1%) were downgraded, and 140 (56.7%) had identical biopsy and pathological Gleason sum groups. Smaller TRUS volume was significantly associated with increased likelihood of upgrading (p trend=0.022). Men with prostates 25 cm³ or less had more than 2.7 times the risk of disease being upgraded relative to men with TRUS volumes more than 40 cm³ (OR 2.718, 95% CI 1.403-8.126). CONCLUSION: In our study, smaller prostate volumes were at increased risk for GS upgrading after RP. This finding should be kept in mind when making treatment decisions for men with prostate cancer that appears to be of a low grade on biopsy, especially in Asian urologic fields.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHBiopsy-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHProstate/diagnostic imaging-
dc.subject.MESHProstate/pathology-
dc.subject.MESHProstatectomy/methods*-
dc.subject.MESHProstatic Neoplasms/diagnostic imaging-
dc.subject.MESHProstatic Neoplasms/pathology*-
dc.subject.MESHProstatic Neoplasms/surgery*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHUltrasonography-
dc.titleIs Small Prostate Volume a Predictor of Gleason Score Upgrading after Radical Prostatectomy?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorMun Su Chung-
dc.contributor.googleauthorSeung Hwan Lee-
dc.contributor.googleauthorDong Hoon Lee-
dc.contributor.googleauthorByung Ha Chung-
dc.identifier.doi10.3349/ymj.2013.54.4.902-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02938-
dc.contributor.localIdA02742-
dc.contributor.localIdA03607-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23709424-
dc.subject.keywordProstatic neoplasms-
dc.subject.keywordbiopsy-
dc.subject.keywordprostatectomy-
dc.contributor.alternativeNameLee, Dong Hoon-
dc.contributor.alternativeNameLee, Seung Hwan-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.affiliatedAuthorLee, Seung Hwan-
dc.contributor.affiliatedAuthorLee, Dong Hoon-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.rights.accessRightsfree-
dc.citation.volume54-
dc.citation.number4-
dc.citation.startPage902-
dc.citation.endPage906-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.54(4) : 902-906, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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