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약물 오남용의 신경생물학적 기전과 약동학 및 약력학

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dc.contributor.author김소연-
dc.contributor.author이종석-
dc.contributor.author한동우-
dc.date.accessioned2014-12-18T09:17:36Z-
dc.date.available2014-12-18T09:17:36Z-
dc.date.issued2013-
dc.identifier.issn1975-8456-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87898-
dc.description.abstractAll drugs of abuse, like neural rewarding behaviors such as sex and eating, increase extra-cellular dopamine (DA) levels in the nucleus accumbens (NA), which is a part of the common reward mesolimbic pathway from the ventral tegmental area (VTA) to the NA. As addiction progresses from initial use to obsessive compulsive use, the neurobiology shifts from a DA-based behavioral system to a predominantly glutamate-based one, still relying on DA. A DA release in the prefrontal cortex (PFC) and amygdala in the relapse stimulates glutamate transmission between the PFC and amygdala and glutamate release in the pathway from the PFC to the NA core, constituting a "final common pathway" for drug-seeking behavior. Dysfunction of critical PFC structures results in drug craving and impaired decision making. Inhalation and smoking are the routes of administration that allow the most rapid delivery of drugs to the brain, while intravenous injection maximizes the bioavailability of a drug. The pharmacokinetic properties of a drug that dispose the user to increased self-administration include rapid absorption, rapid entry into the central nervous system, high bioavailability, short half-life, small volume of distribution, and high free drug clearance. The pharmacokinetic properties associated with drug dependence are a long half-life, low free drug clearance, and presence of the drug at high enough concentrations and for a sufficient time to permit tolerance to develop. Pharmacokinetics and pharmacodynamics play an important role in predicting the dependence and abuse potential of drugs.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF THE KOREAN MEDICAL ASSOCIATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title약물 오남용의 신경생물학적 기전과 약동학 및 약력학-
dc.title.alternativeNeurobiology, pharmacokinetics and pharmacodynamics of drug abuse-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthor김소연-
dc.contributor.googleauthor이종석-
dc.contributor.googleauthor한동우-
dc.identifier.doi10.5124/jkma.2013.56.9.762-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04274-
dc.contributor.localIdA03141-
dc.contributor.localIdA00616-
dc.relation.journalcodeJ01833-
dc.identifier.eissn2093-5951-
dc.identifier.pmidSubstance-related disorders ; Dopamine ; Neurobiology ; Pharmacokinetics ; Pharmacology-
dc.subject.keywordSubstance-related disorders-
dc.subject.keywordDopamine-
dc.subject.keywordNeurobiology-
dc.subject.keywordPharmacokinetics-
dc.subject.keywordPharmacology-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameLee, Jong Seok-
dc.contributor.alternativeNameHan, Dong Woo-
dc.contributor.affiliatedAuthorHan, Dong Woo-
dc.contributor.affiliatedAuthorLee, Jong Seok-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.rights.accessRightsfree-
dc.citation.volume56-
dc.citation.number9-
dc.citation.startPage762-
dc.citation.endPage770-
dc.identifier.bibliographicCitationJOURNAL OF THE KOREAN MEDICAL ASSOCIATION , Vol.56(9) : 762-770, 2013-
dc.identifier.rimsid32598-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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