Cited 48 times in

Antibiotic Resistance in Helicobacter pylori Strains and its Effect on H. pylori Eradication Rates in a Single Center in Korea

DC Field Value Language
dc.contributor.author김희정-
dc.contributor.author문병수-
dc.contributor.author이용찬-
dc.contributor.author임현철-
dc.date.accessioned2014-12-18T09:17:18Z-
dc.date.available2014-12-18T09:17:18Z-
dc.date.issued2013-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87888-
dc.description.abstractBACKGROUND: Clarithromycin, amoxicillin, metronidazole, tetracycline, and levofloxacin have been commonly used for the eradication of Helicobacter pylori. We compared the change in antibiotic resistance of H. pylori strains during two separate periods and investigated the effect of antibiotic resistance on H. pylori eradication. METHODS: H. pylori strains were isolated from 71 patients between 2009 and 2010 and from 94 patients between 2011 and 2012. The distribution of minimal inhibitory concentration (MIC) of 5 antibiotics was assessed using the agar dilution method, and H. pylori eradication based on the antimicrobial susceptibility of the isolates was investigated retrospectively. RESULTS: Antibiotic resistance rate against clarithromycin, amoxicillin, tetracycline, metronidazole, and levofloxacin for the 2009-2010 isolates were 7.0% (5/71), 2.8% (2/71), 0% (0/71), 45.1% (32/71), and 26.8% (19/71), respectively, and for the 2011-2012 isolates were 16.0% (15/94), 2.1% (2/94), 0% (0/94), 56.3% (53/94), and 22.3% (21/94), respectively. Multi-drug resistance for 2 or more antibiotics increased slightly from 16.9% (12/71) in the 2009-2010 isolates to 23.4% (22/94) in the 2011-2012 isolates. In follow-up testing of 66 patients, first-line treatment successfully eradicated H. pylori in 50 patients (75.8%) and failed in 4 of 7 patients (57.1%) in a clarithromycin-resistant and amoxicillin-susceptible group. CONCLUSIONS: We observed an increase in resistance to clarithromycin and an overall increase in multi-drug resistance during the 2 study periods. The effectiveness of the eradication regimen was low with combinations of clarithromycin and amoxicillin, particularly in the clarithromycin-resistant group. Thus, eradication of H. pylori depends upon periodic monitoring of antimicrobial susceptibility.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANNALS OF LABORATORY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use-
dc.subject.MESHDrug Resistance, Multiple, Bacterial/drug effects*-
dc.subject.MESHFemale-
dc.subject.MESHHelicobacter Infections/drug therapy-
dc.subject.MESHHelicobacter Infections/microbiology*-
dc.subject.MESHHelicobacter pylori/drug effects*-
dc.subject.MESHHelicobacter pylori/isolation & purification-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeptic Ulcer/diagnosis-
dc.subject.MESHPeptic Ulcer/microbiology-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleAntibiotic Resistance in Helicobacter pylori Strains and its Effect on H. pylori Eradication Rates in a Single Center in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorByoungrak An-
dc.contributor.googleauthorByung Soo Moon-
dc.contributor.googleauthorHeejung Kim-
dc.contributor.googleauthorHyun Chul Lim-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorGyusang Lee-
dc.contributor.googleauthorSa-Hyun Kim-
dc.contributor.googleauthorMin Park-
dc.contributor.googleauthorJong Bae Kim-
dc.identifier.doi10.3343/alm.2013.33.6.415-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01356-
dc.contributor.localIdA02988-
dc.contributor.localIdA03418-
dc.contributor.localIdA01219-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.identifier.pmid24205490-
dc.subject.keywordAntibiotic resistance-
dc.subject.keywordEradication-
dc.subject.keywordHelicobacter pylori-
dc.contributor.alternativeNameKim, Hee Jung-
dc.contributor.alternativeNameMoon, Byung Soo-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLim, Hyun Chul-
dc.contributor.affiliatedAuthorMoon, Byung Soo-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLim, Hyun Chul-
dc.contributor.affiliatedAuthorKim, Heejung-
dc.rights.accessRightsfree-
dc.citation.volume33-
dc.citation.number6-
dc.citation.startPage1-
dc.citation.endPage5-
dc.identifier.bibliographicCitationANNALS OF LABORATORY MEDICINE, Vol.33(6) : 1-5, 2013-
dc.identifier.rimsid32593-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.