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Therapeutic Strategies for Well-differentiated Papillary Mesothelioma of the Peritoneum

DC FieldValueLanguage
dc.contributor.author김효송-
dc.contributor.author라선영-
dc.contributor.author박지수-
dc.contributor.author안중배-
dc.contributor.author양우익-
dc.contributor.author이영기-
dc.contributor.author임태섭-
dc.contributor.author정현철-
dc.date.accessioned2014-12-18T09:14:20Z-
dc.date.available2014-12-18T09:14:20Z-
dc.date.issued2013-
dc.identifier.issn0368-2811-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87794-
dc.description.abstractOBJECTIVE: Well-differentiated papillary mesothelioma is an uncommon subtype of mesothelioma with a frequently indolent course, although it occasionally manifests in a more aggressive form. To establish a treatment strategy for this rare disease, we report the clinical characteristics and outcomes of 15 patients with well-differentiated papillary mesothelioma. METHODS: All pathologically diagnosed well-differentiated papillary mesothelioma cases were reviewed between 1998 and 2012. RESULTS: Of the 15 cases, 8 and 7 presented with single and multiple lesions, respectively. All cases with single lesions were asymptomatic, while 4 out of the 7 cases with multiple lesions were symptomatic. After tumor excision, none of the eight single-lesion cases experienced tumor recurrence. Among the other seven cases with multiple lesions, only one patient with disseminated lesions died due to disease burden. Five patients with multiple lesions received cisplatin-based intravenous or intraperitoneal chemotherapy, with a mix of complete (n= 2) and partial (n= 2) responses observed. Of particular note, one patient receiving cisplatin and pemetrexed combination chemotherapy experienced complete tumor resolution without any serious toxicity. CONCLUSIONS: We recommend different treatment strategies based on the disease status. If the tumor is completely resectable, an excisional biopsy seems to be sufficient. If complete resection is unavailable for the asymptomatic patient with a localized tumor extent, close follow-up is an appropriate option. When the tumor is extensive or accompanied by symptoms, chemotherapy should be strongly considered.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJapanese Journal of Clinical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntibodies, Monoclonal, Murine-Derived/analysis-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use*-
dc.subject.MESHBiomarkers, Tumor/analysis*-
dc.subject.MESHCalbindin 2-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHCisplatin/administration & dosage-
dc.subject.MESHFemale-
dc.subject.MESHGlutamates/administration & dosage-
dc.subject.MESHGuanine/administration & dosage-
dc.subject.MESHGuanine/analogs & derivatives-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHInfusions, Parenteral-
dc.subject.MESHMale-
dc.subject.MESHMesothelioma/chemistry-
dc.subject.MESHMesothelioma/diagnosis*-
dc.subject.MESHMesothelioma/drug therapy-
dc.subject.MESHMesothelioma/pathology-
dc.subject.MESHMesothelioma/surgery-
dc.subject.MESHMesothelioma/therapy*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultimodal Imaging-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis-
dc.subject.MESHNeoplasm Recurrence, Local/therapy-
dc.subject.MESHPemetrexed-
dc.subject.MESHPeritoneal Neoplasms/chemistry-
dc.subject.MESHPeritoneal Neoplasms/diagnosis*-
dc.subject.MESHPeritoneal Neoplasms/drug therapy-
dc.subject.MESHPeritoneal Neoplasms/pathology-
dc.subject.MESHPeritoneal Neoplasms/surgery-
dc.subject.MESHPeritoneal Neoplasms/therapy*-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHPrognosis-
dc.subject.MESHRisk Factors-
dc.subject.MESHS100 Calcium Binding Protein G/analysis-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHTreatment Outcome-
dc.titleTherapeutic Strategies for Well-differentiated Papillary Mesothelioma of the Peritoneum-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorYoung Ki Lee-
dc.contributor.googleauthorHyun Jung Jun-
dc.contributor.googleauthorJi Hae Nahm-
dc.contributor.googleauthorTae Seop Lim-
dc.contributor.googleauthorJi Soo Park-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorHwa Eun Oh-
dc.contributor.googleauthorJi-Sun Song-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorHyo Song Kim-
dc.identifier.doi10.1093/jjco/hyt117-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01202-
dc.contributor.localIdA01686-
dc.contributor.localIdA02262-
dc.contributor.localIdA02300-
dc.contributor.localIdA02953-
dc.contributor.localIdA03414-
dc.contributor.localIdA03773-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ01207-
dc.identifier.pmid23964112-
dc.subject.keywordchemotherapy-
dc.subject.keywordcisplatin-
dc.subject.keywordpemetrexed-
dc.subject.keywordperitoneum-
dc.subject.keywordtherapeutic strategy-
dc.subject.keywordwell-differentiated papillary mesothelioma-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNamePark, Ji Soo-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLee, Young Ki-
dc.contributor.alternativeNameLim, Tae Seop-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorPark, Ji Soo-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Young Ki-
dc.contributor.affiliatedAuthorLim, Tae Seop-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.rights.accessRightsfree-
dc.citation.volume43-
dc.citation.number10-
dc.citation.startPage996-
dc.citation.endPage1003-
dc.identifier.bibliographicCitationJapanese Journal of Clinical Oncology, Vol.43(10) : 996-1003, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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