Cited 36 times in
Prediction of metachronous multiple primary cancers following the curative resection of gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 정희철 | - |
dc.contributor.author | 강버들 | - |
dc.contributor.author | 김기열 | - |
dc.contributor.author | 김찬 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 전홍재 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2014-12-18T09:13:46Z | - |
dc.date.available | 2014-12-18T09:13:46Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87776 | - |
dc.description.abstract | BACKGROUND: Due to improved survival rate, gastric cancer (GC) patients have an increased risk of developing multiple primary cancer (MPC). The purpose of this study is to evaluate the clinicopathological features of MPC and to generate useful tools for the prediction of metachronous MPC following gastrectomy. METHODS: 3066 patients who underwent curative resection of GC were reviewed retrospectively, based on the clinical information and the medical record. RESULTS: The 5-year incidence of MPC was 2.5%. Of these, 54.3% had a metachronous MPC, while 45.7% had a synchronous MPC. The most prevalent site of metachronous MPC was the colorectum (26.3%), followed by lung (23.7%) and liver (18.4%). Multivariate logistic regression analysis revealed that old age at the time of GC diagnosis (>=60 years), early stage of GC (stage I and II), and multiplicity of GC at the time of gastrectomy were independent predictive factors for metachronous MPC. GC patients with either metachronous or synchronous MPC showed poorer survival than patients without MPC. In addition, patients with a metachronous MPC showed late survival disadvantage, while patients with a synchronous MPC showed early survival disadvantage. Furthermore, we were able to develop and internally validate a nomogram to predict the metachronous MPC after curative gastrectomy (C-index = 0.72). CONCLUSION: Patients at high risk of developing metachronous MPC after curative resection of GC were identified. Individual risk of developing metachronous MPC could be predicted by a novel nomogram. Further external validation with independent patient cohorts is required to improve the accuracy of prediction. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adenocarcinoma/surgery* | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/mortality | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/pathology | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/surgery* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Signet Ring Cell/mortality | - |
dc.subject.MESH | Carcinoma, Signet Ring Cell/pathology | - |
dc.subject.MESH | Carcinoma, Signet Ring Cell/surgery* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gastrectomy/adverse effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Neoplasms, Multiple Primary/diagnosis* | - |
dc.subject.MESH | Neoplasms, Multiple Primary/epidemiology | - |
dc.subject.MESH | Neoplasms, Multiple Primary/etiology | - |
dc.subject.MESH | Neoplasms, Multiple Primary/mortality | - |
dc.subject.MESH | Nomograms | - |
dc.subject.MESH | Postoperative Complications/diagnosis | - |
dc.subject.MESH | Postoperative Complications/epidemiology | - |
dc.subject.MESH | Postoperative Complications/etiology | - |
dc.subject.MESH | Postoperative Complications/mortality | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stomach Neoplasms/mortality | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/surgery* | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Prediction of metachronous multiple primary cancers following the curative resection of gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Chan Kim | - |
dc.contributor.googleauthor | Hong Jae Chon | - |
dc.contributor.googleauthor | Beodeul Kang | - |
dc.contributor.googleauthor | Kiyeol Kim | - |
dc.contributor.googleauthor | Hei-Cheul Jeung | - |
dc.contributor.googleauthor | Hyun Cheol Chung5 | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.identifier.doi | 10.1186/1471-2407-13-394 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00029 | - |
dc.contributor.localId | A00337 | - |
dc.contributor.localId | A01034 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A03565 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00351 | - |
dc.identifier.eissn | 1471-2407 | - |
dc.identifier.pmid | 23967865 | - |
dc.subject.keyword | Multiple primary cancer | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Nomogram | - |
dc.subject.keyword | Predictive factor | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.alternativeName | Kang, Beo Deul | - |
dc.contributor.alternativeName | Kim, Ki Yeol | - |
dc.contributor.alternativeName | Kim, Chan | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Chon, Hong Jae | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Kang, Beo Deul | - |
dc.contributor.affiliatedAuthor | Kim, Ki Yeol | - |
dc.contributor.affiliatedAuthor | Kim, Chan | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Chon, Hong Jae | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 13 | - |
dc.citation.startPage | 394 | - |
dc.identifier.bibliographicCitation | BMC CANCER, Vol.13 : 394, 2013 | - |
dc.identifier.rimsid | 32263 | - |
dc.type.rims | ART | - |
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