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Prediction of metachronous multiple primary cancers following the curative resection of gastric cancer

DC FieldValueLanguage
dc.contributor.author정희철-
dc.contributor.author강버들-
dc.contributor.author김기열-
dc.contributor.author김찬-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author전홍재-
dc.contributor.author정현철-
dc.date.accessioned2014-12-18T09:13:46Z-
dc.date.available2014-12-18T09:13:46Z-
dc.date.issued2013-
dc.identifier.issn1471-2407-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87776-
dc.description.abstractBACKGROUND: Due to improved survival rate, gastric cancer (GC) patients have an increased risk of developing multiple primary cancer (MPC). The purpose of this study is to evaluate the clinicopathological features of MPC and to generate useful tools for the prediction of metachronous MPC following gastrectomy. METHODS: 3066 patients who underwent curative resection of GC were reviewed retrospectively, based on the clinical information and the medical record. RESULTS: The 5-year incidence of MPC was 2.5%. Of these, 54.3% had a metachronous MPC, while 45.7% had a synchronous MPC. The most prevalent site of metachronous MPC was the colorectum (26.3%), followed by lung (23.7%) and liver (18.4%). Multivariate logistic regression analysis revealed that old age at the time of GC diagnosis (>=60 years), early stage of GC (stage I and II), and multiplicity of GC at the time of gastrectomy were independent predictive factors for metachronous MPC. GC patients with either metachronous or synchronous MPC showed poorer survival than patients without MPC. In addition, patients with a metachronous MPC showed late survival disadvantage, while patients with a synchronous MPC showed early survival disadvantage. Furthermore, we were able to develop and internally validate a nomogram to predict the metachronous MPC after curative gastrectomy (C-index = 0.72). CONCLUSION: Patients at high risk of developing metachronous MPC after curative resection of GC were identified. Individual risk of developing metachronous MPC could be predicted by a novel nomogram. Further external validation with independent patient cohorts is required to improve the accuracy of prediction.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBMC Cancer-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrediction of metachronous multiple primary cancers following the curative resection of gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorChan Kim-
dc.contributor.googleauthorHong Jae Chon-
dc.contributor.googleauthorBeodeul Kang-
dc.contributor.googleauthorKiyeol Kim-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorHyun Cheol Chung5-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorSun Young Rha-
dc.identifier.doi10.1186/1471-2407-13-394-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00029-
dc.contributor.localIdA00337-
dc.contributor.localIdA01034-
dc.contributor.localIdA01281-
dc.contributor.localIdA03565-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ00351-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.alternativeNameKang, Beo Deul-
dc.contributor.alternativeNameKim, Ki Yeol-
dc.contributor.alternativeNameKim, Chan-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameChon, Hong Jae-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.affiliatedAuthorKang, Beo Deul-
dc.contributor.affiliatedAuthorKim, Ki Yeol-
dc.contributor.affiliatedAuthorKim, Chan-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorChon, Hong Jae-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.rights.accessRightsfree-
dc.citation.volume13-
dc.citation.startPage394-
dc.citation.endPage394-
dc.identifier.bibliographicCitationBMC Cancer, Vol.13 : 394-394, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers

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