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The impact of low triiodothyronine levels on mortality is mediated by malnutrition and cardiac dysfunction in incident hemodialysis patients

DC Field Value Language
dc.contributor.author강신욱-
dc.contributor.author구향모-
dc.contributor.author김은진-
dc.contributor.author김찬호-
dc.contributor.author도화미-
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author이미정-
dc.contributor.author한승혁-
dc.contributor.author한재현-
dc.contributor.author한지숙-
dc.date.accessioned2014-12-18T09:13:18Z-
dc.date.available2014-12-18T09:13:18Z-
dc.date.issued2013-
dc.identifier.issn0804-4643-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87761-
dc.description.abstractOBJECTIVE: Little is known about the impact of low triiodothyronine (T3) levels on mortality in end-stage renal disease (ESRD) patients starting hemodialysis (HD) and whether this impact is mediated by malnutrition, inflammation, or cardiac dysfunction. DESIGN AND METHODS: A prospective cohort of 471 incident HD patients from 36 dialysis centers within the Clinical Research Center for ESRD in Korea was selected for this study. Based on the median value of T3, patients were divided into 'higher' and 'lower' groups, and all-cause and cardiovascular (CV) mortality rates were compared. In addition, associations between T3 levels and various nutritional, inflammatory, and echocardiographic parameters were determined. RESULTS: Compared with those in the 'higher' T3 group, albumin, cholesterol, and triglyceride levels, lean body mass estimated by creatinine kinetics (LBM-Cr), and normalized protein catabolic rate (nPCR) were significantly lower in patients with 'lower' T3 levels. The 'lower' T3 group also had a higher left ventricular mass index (LVMI) and a lower ejection fraction (EF). Furthermore, correlation analysis revealed significant associations between T3 levels and nutritional and echocardiographic parameters. All-cause and CV mortality rates were significantly higher in patients with 'lower' T3 levels than in the 'higher' T3 group (113.4 vs 18.2 events per 1000 patient-years, P<0.001, and 49.8 vs 9.1 events per 1000 patient-years, P=0.001, respectively). The Kaplan-Meier analysis also showed significantly worse cumulative survival rates in the 'lower' T3 group (P<0.001). In the Cox regression analysis, low T3 was an independent predictor of all-cause mortality even after adjusting for traditional risk factors (hazard ratio=3.76, P=0.021). However, the significant impact of low T3 on all-cause mortality disappeared when LBM-Cr, nPCR, LVMI, or EF were incorporated into the models.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfEUROPEAN JOURNAL OF ENDOCRINOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHEchocardiography-
dc.subject.MESHFemale-
dc.subject.MESHHeart Diseases/blood-
dc.subject.MESHHeart Diseases/diagnostic imaging-
dc.subject.MESHHeart Diseases/mortality*-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHInflammation/blood-
dc.subject.MESHInflammation/mortality-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHKidney Failure, Chronic/blood-
dc.subject.MESHKidney Failure, Chronic/mortality*-
dc.subject.MESHKidney Failure, Chronic/therapy-
dc.subject.MESHMale-
dc.subject.MESHMalnutrition/blood-
dc.subject.MESHMalnutrition/mortality*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRenal Dialysis*-
dc.subject.MESHTriiodothyronine/blood*-
dc.titleThe impact of low triiodothyronine levels on mortality is mediated by malnutrition and cardiac dysfunction in incident hemodialysis patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorChan Ho Kim-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorEun Jin Kim-
dc.contributor.googleauthorJae Hyun Han-
dc.contributor.googleauthorJi Suk Han-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi10.1530/EJE-13-0540-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA00203-
dc.contributor.localIdA01037-
dc.contributor.localIdA01315-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA04304-
dc.contributor.localIdA04320-
dc.contributor.localIdA04327-
dc.contributor.localIdA00823-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ00819-
dc.identifier.eissn1479-683X-
dc.identifier.pmid23857979-
dc.identifier.urlhttp://eje-online.org/content/169/4/409.long-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordEchocardiography-
dc.subject.keywordFemale-
dc.subject.keywordHeart Diseases/blood-
dc.subject.keywordHeart Diseases/diagnostic imaging-
dc.subject.keywordHeart Diseases/mortality*-
dc.subject.keywordHumans-
dc.subject.keywordIncidence-
dc.subject.keywordInflammation/blood-
dc.subject.keywordInflammation/mortality-
dc.subject.keywordKaplan-Meier Estimate-
dc.subject.keywordKidney Failure, Chronic/blood-
dc.subject.keywordKidney Failure, Chronic/mortality*-
dc.subject.keywordKidney Failure, Chronic/therapy-
dc.subject.keywordMale-
dc.subject.keywordMalnutrition/blood-
dc.subject.keywordMalnutrition/mortality*-
dc.subject.keywordMiddle Aged-
dc.subject.keywordPredictive Value of Tests-
dc.subject.keywordProportional Hazards Models-
dc.subject.keywordProspective Studies-
dc.subject.keywordRenal Dialysis*-
dc.subject.keywordTriiodothyronine/blood*-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameKim, Eun Jin-
dc.contributor.alternativeNameKim, Chan Ho-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameHan, Jae Hyun-
dc.contributor.alternativeNameHahn, Jee Sook-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorKim, Chan Ho-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorHan, Jae Hyun-
dc.contributor.affiliatedAuthorHahn, Jee Sook-
dc.contributor.affiliatedAuthorKim, Eun Jin-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.rights.accessRightsnot free-
dc.citation.volume169-
dc.citation.number4-
dc.citation.startPage409-
dc.citation.endPage419-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol.169(4) : 409-419, 2013-
dc.identifier.rimsid32257-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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