Cited 15 times in
The impact of low triiodothyronine levels on mortality is mediated by malnutrition and cardiac dysfunction in incident hemodialysis patients
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 구향모 | - |
dc.contributor.author | 김은진 | - |
dc.contributor.author | 김찬호 | - |
dc.contributor.author | 도화미 | - |
dc.contributor.author | 오형중 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 한재현 | - |
dc.contributor.author | 한지숙 | - |
dc.date.accessioned | 2014-12-18T09:13:18Z | - |
dc.date.available | 2014-12-18T09:13:18Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0804-4643 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87761 | - |
dc.description.abstract | OBJECTIVE: Little is known about the impact of low triiodothyronine (T3) levels on mortality in end-stage renal disease (ESRD) patients starting hemodialysis (HD) and whether this impact is mediated by malnutrition, inflammation, or cardiac dysfunction. DESIGN AND METHODS: A prospective cohort of 471 incident HD patients from 36 dialysis centers within the Clinical Research Center for ESRD in Korea was selected for this study. Based on the median value of T3, patients were divided into 'higher' and 'lower' groups, and all-cause and cardiovascular (CV) mortality rates were compared. In addition, associations between T3 levels and various nutritional, inflammatory, and echocardiographic parameters were determined. RESULTS: Compared with those in the 'higher' T3 group, albumin, cholesterol, and triglyceride levels, lean body mass estimated by creatinine kinetics (LBM-Cr), and normalized protein catabolic rate (nPCR) were significantly lower in patients with 'lower' T3 levels. The 'lower' T3 group also had a higher left ventricular mass index (LVMI) and a lower ejection fraction (EF). Furthermore, correlation analysis revealed significant associations between T3 levels and nutritional and echocardiographic parameters. All-cause and CV mortality rates were significantly higher in patients with 'lower' T3 levels than in the 'higher' T3 group (113.4 vs 18.2 events per 1000 patient-years, P<0.001, and 49.8 vs 9.1 events per 1000 patient-years, P=0.001, respectively). The Kaplan-Meier analysis also showed significantly worse cumulative survival rates in the 'lower' T3 group (P<0.001). In the Cox regression analysis, low T3 was an independent predictor of all-cause mortality even after adjusting for traditional risk factors (hazard ratio=3.76, P=0.021). However, the significant impact of low T3 on all-cause mortality disappeared when LBM-Cr, nPCR, LVMI, or EF were incorporated into the models. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Echocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Diseases/blood | - |
dc.subject.MESH | Heart Diseases/diagnostic imaging | - |
dc.subject.MESH | Heart Diseases/mortality* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Inflammation/blood | - |
dc.subject.MESH | Inflammation/mortality | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Kidney Failure, Chronic/blood | - |
dc.subject.MESH | Kidney Failure, Chronic/mortality* | - |
dc.subject.MESH | Kidney Failure, Chronic/therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Malnutrition/blood | - |
dc.subject.MESH | Malnutrition/mortality* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Renal Dialysis* | - |
dc.subject.MESH | Triiodothyronine/blood* | - |
dc.title | The impact of low triiodothyronine levels on mortality is mediated by malnutrition and cardiac dysfunction in incident hemodialysis patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyang Mo Koo | - |
dc.contributor.googleauthor | Chan Ho Kim | - |
dc.contributor.googleauthor | Fa Mee Doh | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Eun Jin Kim | - |
dc.contributor.googleauthor | Jae Hyun Han | - |
dc.contributor.googleauthor | Ji Suk Han | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.identifier.doi | 10.1530/EJE-13-0540 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00203 | - |
dc.contributor.localId | A01037 | - |
dc.contributor.localId | A01315 | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A04320 | - |
dc.contributor.localId | A04327 | - |
dc.contributor.localId | A00823 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J00819 | - |
dc.identifier.eissn | 1479-683X | - |
dc.identifier.pmid | 23857979 | - |
dc.identifier.url | http://eje-online.org/content/169/4/409.long | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Echocardiography | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Heart Diseases/blood | - |
dc.subject.keyword | Heart Diseases/diagnostic imaging | - |
dc.subject.keyword | Heart Diseases/mortality* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Incidence | - |
dc.subject.keyword | Inflammation/blood | - |
dc.subject.keyword | Inflammation/mortality | - |
dc.subject.keyword | Kaplan-Meier Estimate | - |
dc.subject.keyword | Kidney Failure, Chronic/blood | - |
dc.subject.keyword | Kidney Failure, Chronic/mortality* | - |
dc.subject.keyword | Kidney Failure, Chronic/therapy | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Malnutrition/blood | - |
dc.subject.keyword | Malnutrition/mortality* | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Predictive Value of Tests | - |
dc.subject.keyword | Proportional Hazards Models | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | Renal Dialysis* | - |
dc.subject.keyword | Triiodothyronine/blood* | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Koo, Hyang Mo | - |
dc.contributor.alternativeName | Kim, Eun Jin | - |
dc.contributor.alternativeName | Kim, Chan Ho | - |
dc.contributor.alternativeName | Doh, Fa Mee | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Han, Jae Hyun | - |
dc.contributor.alternativeName | Hahn, Jee Sook | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Koo, Hyang Mo | - |
dc.contributor.affiliatedAuthor | Kim, Chan Ho | - |
dc.contributor.affiliatedAuthor | Doh, Fa Mee | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Han, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Hahn, Jee Sook | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jin | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 169 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 409 | - |
dc.citation.endPage | 419 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol.169(4) : 409-419, 2013 | - |
dc.identifier.rimsid | 32257 | - |
dc.type.rims | ART | - |
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