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Increasing prevalence of bla(OXA-23)-carrying Acinetobacter baumannii and the emergence of bla(OXA-182)-carrying Acinetobacter nosocomialis in Korea

Authors
 Yangsoon Lee  ;  Young-Ree Kim  ;  Jayoung Kim  ;  Yeon-Joon Park  ;  Wonkeun Song  ;  Jong-Hee Shin  ;  Young Uh  ;  Kyutaeg Lee  ;  Seong Hee Lee  ;  Ji Hyun Cho  ;  Dongeun Yong  ;  Seok Hoon Jeong  ;  Kyungwon Lee  ;  Yunsop Chong 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.77(2) : 160-163, 2013 
Journal Title
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 
ISSN
 0732-8893 
Issue Date
2013
MeSH
Acinetobacter Infections/epidemiology ; Acinetobacter Infections/microbiology* ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/enzymology* ; Acinetobacter baumannii/genetics ; Acinetobacter baumannii/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/genetics ; Cross Infection/epidemiology ; Cross Infection/microbiology* ; Humans ; Microbial Sensitivity Tests ; Phylogeny ; Prevalence ; Republic of Korea/epidemiology ; Retrospective Studies ; beta-Lactam Resistance/genetics ; beta-Lactamases/biosynthesis* ; beta-Lactamases/genetics
Keywords
Acinetobacter baumannii ; Acinetobacter nosocomialis ; bla(OXA-182) ; bla(OXA-23)
Abstract
Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent bla(OXA) genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of bla(OXA) genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of bla(OXA)-23-like, ISAba1-associated bla(OXA-51)-like, and bla(OXA-182) genes were 44.0%, 49.7%, and 5.1%, respectively. The bla(OXA-58)-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with bla(OXA-23)-like genes and a decrease in isolates harboring ISAba1-associated bla(OXA-51)-like genes have been observed since the mid-2000s. The bla(OXA-23)-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that bla(OXA-182)-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889313003416
DOI
10.1016/j.diagmicrobio.2013.06.009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Yang Soon(이양순)
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87731
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