Cited 8 times in
Clinical necessity of the immunohistochemical reassessment of para-aortic lymph nodes in resected pancreatic ductal adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 최성훈 | - |
dc.contributor.author | 황호경 | - |
dc.contributor.author | 강창무 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 이우정 | - |
dc.date.accessioned | 2014-12-18T09:11:15Z | - |
dc.date.available | 2014-12-18T09:11:15Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87696 | - |
dc.description.abstract | Para-aortic lymph node (PALN) metastasis is widely regarded as a systemic disease in cancer. Undetected PALN micrometastases during routine hematoxylin and eosin (HE) staining may be a cause of poor prognosis following a potentially curative pancreatectomy for pancreatic cancer. In the present study, paraffin-embedded PALN tissue blocks from 99 patients who underwent a pancreatectomy were re-evaluated by immunohistochemical staining using cytokeratin (CK)-19. Patients with PALN metastasis were summarized according to the clinicopathological data. A total of 484 PALNs (median, 4.9 nodes per patient; range, 1–19) were evaluated. PALN metastases were revealed in eight patients (8.1%) by routine HE staining of frozen section biopsies and in one patient (1.0%) by HE staining of a permanent section. Only one patient (1.0%) demonstrated micrometastasis by IHC; this patient did not display any adverse pathological characteristics and had a relatively favorable survival period of 41 months. The present study concluded that an additional reassessment for micrometastasis in PALNs using CK-19 immunohistochemistry (IHC) is not a viable method for determining the survival outcome. A careful examination of a frozen section biopsy is sufficient for attempting curative surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical necessity of the immunohistochemical reassessment of para-aortic lymph nodes in resected pancreatic ductal adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | SUNG HOON CHOI | - |
dc.contributor.googleauthor | SE HOON KIM | - |
dc.contributor.googleauthor | JUN JEONG CHOI | - |
dc.contributor.googleauthor | CHANG MOO KANG | - |
dc.contributor.googleauthor | HO KYOUNG HWANG | - |
dc.contributor.googleauthor | WOO JUNG LEE | - |
dc.identifier.doi | 10.3892/ol.2013.1539 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04085 | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A04497 | - |
dc.contributor.localId | A00088 | - |
dc.contributor.localId | A00610 | - |
dc.relation.journalcode | J02417 | - |
dc.identifier.eissn | 1792-1082 | - |
dc.identifier.pmid | 24179493 | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | micrometastasis | - |
dc.subject.keyword | pancreatic cancer | - |
dc.subject.keyword | paraaortic lymph node | - |
dc.contributor.alternativeName | Choi, Sung Hoon | - |
dc.contributor.alternativeName | Hwang, Ho Kyoung | - |
dc.contributor.alternativeName | Kang, Chang Moo | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Choi, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Hwang, Ho Kyoung | - |
dc.contributor.affiliatedAuthor | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 6 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1189 | - |
dc.citation.endPage | 1194 | - |
dc.identifier.bibliographicCitation | ONCOLOGY LETTERS, Vol.6(5) : 1189-1194, 2013 | - |
dc.identifier.rimsid | 32216 | - |
dc.type.rims | ART | - |
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