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Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells

DC FieldValueLanguage
dc.contributor.author강석구-
dc.date.accessioned2014-12-18T09:09:44Z-
dc.date.available2014-12-18T09:09:44Z-
dc.date.issued2013-
dc.identifier.issn1347-9032-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87649-
dc.description.abstractGlioblastoma remains an incurable brain disease due to the prevalence of its recurrence. Considerable evidence suggests that glioma stem-like cells are responsible for glioma relapse after treatment, which commonly involves ionizing radiation. Here, we found that fractionated ionizing radiation (2 Gy/day for 3 days) induced glioma stem-like cell expansion and resistance to anticancer treatment such as cisplatin (50 μM) or taxol (500 nM), or by ionizing radiation (10 Gy) in both glioma cell lines (U87, U373) and patient-derived glioma cells. Of note, concomitant increase of nitric oxide production occurred with the radiation-induced increase of the glioma stem-like cell population through upregulation of inducible nitric oxide synthase (iNOS). In line with this observation, downregulation of iNOS effectively reduced the glioma stem-like cell population and decreased resistance to anticancer treatment. Collectively, our results suggest that targeting iNOS in combination with ionizing radiation might increase the efficacy of radiotherapy for glioma treatment.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCANCER SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBrain Neoplasms/genetics-
dc.subject.MESHBrain Neoplasms/metabolism-
dc.subject.MESHBrain Neoplasms/pathology*-
dc.subject.MESHBrain Neoplasms/radiotherapy*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDose Fractionation-
dc.subject.MESHDown-Regulation-
dc.subject.MESHDrug Resistance, Neoplasm/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGlioblastoma/genetics-
dc.subject.MESHGlioblastoma/metabolism-
dc.subject.MESHGlioblastoma/pathology*-
dc.subject.MESHGlioblastoma/radiotherapy*-
dc.subject.MESHHumans-
dc.subject.MESHNeoplasm Recurrence, Local/genetics-
dc.subject.MESHNeoplasm Recurrence, Local/metabolism-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplastic Stem Cells/metabolism-
dc.subject.MESHNeoplastic Stem Cells/pathology*-
dc.subject.MESHNeoplastic Stem Cells/radiation effects*-
dc.subject.MESHNitric Oxide/biosynthesis*-
dc.subject.MESHNitric Oxide/genetics-
dc.subject.MESHNitric Oxide/metabolism-
dc.subject.MESHNitric Oxide Synthase Type II/genetics-
dc.subject.MESHNitric Oxide Synthase Type II/metabolism-
dc.subject.MESHRadiotherapy/adverse effects-
dc.subject.MESHUp-Regulation-
dc.titleFractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorRae-Kwon Kim-
dc.contributor.googleauthorYongjoon Suh-
dc.contributor.googleauthorYan-Hong Cui-
dc.contributor.googleauthorEunji Hwang-
dc.contributor.googleauthorEun-Jung Lim-
dc.contributor.googleauthorKi-Chun Yoo-
dc.contributor.googleauthorGa-Haeng Lee-
dc.contributor.googleauthorJoo-Mi Yi-
dc.contributor.googleauthorSeok-Gu Kang-
dc.contributor.googleauthorSu-Jae Lee-
dc.identifier.doi10.1111/cas.12207-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00036-
dc.relation.journalcodeJ00454-
dc.identifier.eissn1349-7006-
dc.identifier.pmid23714583-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/cas.12207/abstract-
dc.subject.keywordAged-
dc.subject.keywordBrain Neoplasms/genetics-
dc.subject.keywordBrain Neoplasms/metabolism-
dc.subject.keywordBrain Neoplasms/pathology*-
dc.subject.keywordBrain Neoplasms/radiotherapy*-
dc.subject.keywordCell Line, Tumor-
dc.subject.keywordDose Fractionation-
dc.subject.keywordDown-Regulation-
dc.subject.keywordDrug Resistance, Neoplasm/genetics-
dc.subject.keywordFemale-
dc.subject.keywordGlioblastoma/genetics-
dc.subject.keywordGlioblastoma/metabolism-
dc.subject.keywordGlioblastoma/pathology*-
dc.subject.keywordGlioblastoma/radiotherapy*-
dc.subject.keywordHumans-
dc.subject.keywordNeoplasm Recurrence, Local/genetics-
dc.subject.keywordNeoplasm Recurrence, Local/metabolism-
dc.subject.keywordNeoplasm Recurrence, Local/pathology-
dc.subject.keywordNeoplastic Stem Cells/metabolism-
dc.subject.keywordNeoplastic Stem Cells/pathology*-
dc.subject.keywordNeoplastic Stem Cells/radiation effects*-
dc.subject.keywordNitric Oxide/biosynthesis*-
dc.subject.keywordNitric Oxide/genetics-
dc.subject.keywordNitric Oxide/metabolism-
dc.subject.keywordNitric Oxide Synthase Type II/genetics-
dc.subject.keywordNitric Oxide Synthase Type II/metabolism-
dc.subject.keywordRadiotherapy/adverse effects-
dc.subject.keywordUp-Regulation-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.affiliatedAuthorKang, Seok Gu-
dc.rights.accessRightsnot free-
dc.citation.volume104-
dc.citation.number9-
dc.citation.startPage1172-
dc.citation.endPage1177-
dc.identifier.bibliographicCitationCANCER SCIENCE, Vol.104(9) : 1172-1177, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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