Cited 0 times in
아토피피부염과 피부 장벽 이상
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신정우 | - |
dc.contributor.author | 이광훈 | - |
dc.date.accessioned | 2014-12-18T09:06:40Z | - |
dc.date.available | 2014-12-18T09:06:40Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2288-0402 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87554 | - |
dc.description.abstract | Atopic dermatitis is a chronic relapsing eczematous dermatosis, which usually starts in childhood, and various causes are intricately associated with the development of the disease. Recently, various abnormalities in barrier function have been identified as the cause of atopic dermatitis. Loss-of-function mutation of filaggrin, a significant constituent of skin barrier, has been revealed as a cause for atopic dermatitis, and factors like enhanced protease activity, and decreased synthesis of the lipid lamellae especially ceramides also plays an important role in barrier dysfunction. Not only these genetic causes but also environmental factors are associated in barrier dysfunction, such as soap or detergents which increases skin pH, or proteases of dust mites or cockroaches which enhances epidermal barrier breakdown. Lately, skin barrier dysfunction is also thought to play an important role in the early stage of other allergic diseases such as asthma. Therefore, comprehension of the function of skin barrier can provide help in understanding various allergic diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ALLERGY ASTHMA & RESPIRATORY DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 아토피피부염과 피부 장벽 이상 | - |
dc.title.alternative | Atopic dermatitis and skin barrier dysfunction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | 김현정 | - |
dc.contributor.googleauthor | 신정우 | - |
dc.contributor.googleauthor | 이광훈 | - |
dc.identifier.doi | 10.4168/aard.2013.1.1.20 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02149 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J00065 | - |
dc.identifier.pmid | Atopic dermatitis ; Skin barrier ; Filaggrin ; Ceramide | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | Skin barrier | - |
dc.subject.keyword | Filaggrin | - |
dc.subject.keyword | Ceramide | - |
dc.contributor.alternativeName | Shin, Jung U | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | Shin, Jung U | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 1 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 20 | - |
dc.citation.endPage | 28 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & RESPIRATORY DISEASE, Vol.1(1) : 20-28, 2013 | - |
dc.identifier.rimsid | 34304 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.