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아토피피부염과 피부 장벽 이상

Other Titles
 Atopic dermatitis and skin barrier dysfunction 
Authors
 김현정  ;  신정우  ;  이광훈 
Citation
 ALLERGY ASTHMA & RESPIRATORY DISEASE, Vol.1(1) : 20-28, 2013 
Journal Title
ALLERGY ASTHMA & RESPIRATORY DISEASE
ISSN
 2288-0402 
Issue Date
2013
Keywords
Atopic dermatitis ; Skin barrier ; Filaggrin ; Ceramide
Abstract
Atopic dermatitis is a chronic relapsing eczematous dermatosis, which usually starts in childhood, and various causes are intricately associated with the development of the disease. Recently, various abnormalities in barrier function have been identified as the cause of atopic dermatitis. Loss-of-function mutation of filaggrin, a significant constituent of skin barrier, has been revealed as a cause for atopic dermatitis, and factors like enhanced protease activity, and decreased synthesis of the lipid lamellae especially ceramides also plays an important role in barrier dysfunction. Not only these genetic causes but also environmental factors are associated in barrier dysfunction, such as soap or detergents which increases skin pH, or proteases of dust mites or cockroaches which enhances epidermal barrier breakdown. Lately, skin barrier dysfunction is also thought to play an important role in the early stage of other allergic diseases such as asthma. Therefore, comprehension of the function of skin barrier can provide help in understanding various allergic diseases.
Files in This Item:
T201302691.pdf Download
DOI
10.4168/aard.2013.1.1.20
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jung U(신정우) ORCID logo https://orcid.org/0000-0001-5259-6879
Lee, Kwang Hoon(이광훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87554
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