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P16 Hypermethylation Predicts Surgical Outcome Following Curative Resection of Mid/Distal Bile Duct Cancer

DC Field Value Language
dc.contributor.author이강영-
dc.contributor.author김재근-
dc.contributor.author박영년-
dc.contributor.author박준성-
dc.contributor.author윤동섭-
dc.date.accessioned2014-12-18T09:05:38Z-
dc.date.available2014-12-18T09:05:38Z-
dc.date.issued2013-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87521-
dc.description.abstractBACKGROUND: Bile duct cancer has very poor prognosis. Important prognostic factors include the TNM stage, cell differentiation, and histologic type; however, we often observe patients whose prognosis is not consistent with the TNM stage. Additional prognostic indicators are mandatory to complement those used presently. We evaluated the hypermethylation status of genes for the power to predict overall survival following curative resection of mid/distal bile duct cancer. METHODS: Pyrosequencing hypermethylation status at the loci of interest was analyzed in 65 mid/distal bile duct carcinoma specimens obtained at Severance Hospital of Yonsei University College of Medicine from January 2000 to December 2006. RESULTS: Significant methylation frequencies (MtI >5 %) were obtained for 5 genes (which P16 [17 %], DAPK [54 %], E-cadherin [60 %], RASSF-1 [46.2 %], and hMLH1 [43.1 %]). MtI status of P16, DAPK, and RASSF-1 were correlated with perineural invasion, tumor depth, and age, respectively. In the multivariate analysis of overall survival, the presence of lymph node metastasis and P16 methylation status were identified as independent prognostic factors for overall survival. Patients with unmethylated of P16 had the 3- and 5-year survival rates of 60.8 and 54.9 %, respectively. In patients with hypermethylated P16, the 3- and 5-year survival rates were 27.3 and 0.0 %, respectively. CONCLUSIONS: P16 hypermethylation and lymph node metastasis may predict overall survival in curative resected mid/distal bile duct cancer. Classification of mid/distal bile duct cancer by both genetic and epigenetic profiles may improve the accuracy in predicting outcome and the effectiveness of tailored therapy in these diseases.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptor Proteins, Signal Transducing/genetics-
dc.subject.MESHAged-
dc.subject.MESHBile Duct Neoplasms/genetics*-
dc.subject.MESHBile Duct Neoplasms/pathology*-
dc.subject.MESHBile Duct Neoplasms/surgery-
dc.subject.MESHCadherins/genetics-
dc.subject.MESHCarcinoma/genetics*-
dc.subject.MESHCarcinoma/secondary-
dc.subject.MESHCarcinoma/surgery-
dc.subject.MESHDNA Methylation*-
dc.subject.MESHDeath-Associated Protein Kinases/genetics-
dc.subject.MESHEpigenesis, Genetic-
dc.subject.MESHFemale-
dc.subject.MESHGenes, p16*-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutL Protein Homolog 1-
dc.subject.MESHNuclear Proteins/genetics-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTumor Suppressor Proteins/genetics-
dc.titleP16 Hypermethylation Predicts Surgical Outcome Following Curative Resection of Mid/Distal Bile Duct Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJoon Seong Park-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorJae Keun Kim-
dc.contributor.googleauthorDong Sup Yoon-
dc.identifier.doi10.1245/s10434-013-2908-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02640-
dc.contributor.localIdA00857-
dc.contributor.localIdA01563-
dc.contributor.localIdA01672-
dc.contributor.localIdA02548-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid23478949-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-013-2908-7-
dc.subject.keywordAdaptor Proteins, Signal Transducing/genetics-
dc.subject.keywordAged-
dc.subject.keywordBile Duct Neoplasms/genetics*-
dc.subject.keywordBile Duct Neoplasms/pathology*-
dc.subject.keywordBile Duct Neoplasms/surgery-
dc.subject.keywordCadherins/genetics-
dc.subject.keywordCarcinoma/genetics*-
dc.subject.keywordCarcinoma/secondary-
dc.subject.keywordCarcinoma/surgery-
dc.subject.keywordDNA Methylation*-
dc.subject.keywordDeath-Associated Protein Kinases/genetics-
dc.subject.keywordEpigenesis, Genetic-
dc.subject.keywordFemale-
dc.subject.keywordGenes, p16*-
dc.subject.keywordHumans-
dc.subject.keywordLymphatic Metastasis-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMutL Protein Homolog 1-
dc.subject.keywordNuclear Proteins/genetics-
dc.subject.keywordPredictive Value of Tests-
dc.subject.keywordSurvival Rate-
dc.subject.keywordTreatment Outcome-
dc.subject.keywordTumor Suppressor Proteins/genetics-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.alternativeNameKim, Jae Keun-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Joon Seong-
dc.contributor.alternativeNameYoon, Dong Sup-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.contributor.affiliatedAuthorKim, Jae Keun-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Joon Seong-
dc.contributor.affiliatedAuthorYoon, Dong Sup-
dc.rights.accessRightsnot free-
dc.citation.volume20-
dc.citation.number8-
dc.citation.startPage2511-
dc.citation.endPage2517-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.20(8) : 2511-2517, 2013-
dc.identifier.rimsid34280-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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